L2H2-6OTD diformic

Name: L2H2-6OTD diformic
Brand: MedChemExpress
SKU: HY-148200A
Rating: 5.0 (1 reviews)

Cat. No.: HY-148200A Purity: 99.28%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L2H2-6OTD acetate contains one to four G-quadruplex binding loops and is a telomere inhibitor analog. L2H2-6OTD acetate has telomerase inhibitory activity with an IC₅₀ value of 15 nM.

For research use only. We do not sell to patients.

L2H2-6OTD diformic Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 2800	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 4500	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 8300	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 13300	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L2H2-6OTD diformic:

L2H2-6OTD Get quote

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Biological Activity
Purity & Documentation
References
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Description

L2H2-6OTD acetate contains one to four G-quadruplex binding loops and is a telomere inhibitor analog. L2H2-6OTD acetate has telomerase inhibitory activity with an IC₅₀ value of 15 nM^[1].

Molecular Weight

750.67

Formula

C₃₂H₃₄N₁₀O₁₂

Appearance

Solid

Color

White to off-white

SMILES

O=CO.NCCCC[C@H](NC(C1=COC(C2=COC3=N2)=N1)=O)C4=NC(C5=NC(C6=NC(C(N[C@H](C7=NC3=CO7)CCCCN)=O)=CO6)=CO5)=CO4.O=CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (133.21 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3321 mL	6.6607 mL	13.3214 mL
5 mM	0.2664 mL	1.3321 mL	2.6643 mL
10 mM	0.1332 mL	0.6661 mL	1.3321 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.28%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (256 KB) HNMR (398 KB) RP-HPLC (267 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

References

[1]. Keisuke Iida, et al. Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand. Molecules. 2013 Apr 12;18(4):4328-41. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.3321 mL	6.6607 mL	13.3214 mL	33.3036 mL
	5 mM	0.2664 mL	1.3321 mL	2.6643 mL	6.6607 mL
	10 mM	0.1332 mL	0.6661 mL	1.3321 mL	3.3304 mL
	15 mM	0.0888 mL	0.4440 mL	0.8881 mL	2.2202 mL
	20 mM	0.0666 mL	0.3330 mL	0.6661 mL	1.6652 mL
	25 mM	0.0533 mL	0.2664 mL	0.5329 mL	1.3321 mL
	30 mM	0.0444 mL	0.2220 mL	0.4440 mL	1.1101 mL
	40 mM	0.0333 mL	0.1665 mL	0.3330 mL	0.8326 mL
	50 mM	0.0266 mL	0.1332 mL	0.2664 mL	0.6661 mL
	60 mM	0.0222 mL	0.1110 mL	0.2220 mL	0.5551 mL
	80 mM	0.0167 mL	0.0833 mL	0.1665 mL	0.4163 mL
	100 mM	0.0133 mL	0.0666 mL	0.1332 mL	0.3330 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.