2. Anti-infection Cell Cycle/DNA Damage Apoptosis
  3. Reverse Transcriptase HIV Telomerase Apoptosis
  4. Abacavir sulfate

Abacavir sulfate  (Synonyms: Abacavir Hemisulfate; ABC sulfate)

Cat. No.: HY-17423A Purity: 99.88%
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Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir sulfate can inhibits the replication of HIV. Abacavir sulfate shows anticancer activity in prostate cancer cell lines. Abacavir sulfate can trespass the blood-brain-barrier and suppresses telomerase activity.

For research use only. We do not sell to patients.

Abacavir sulfate Chemical Structure

Abacavir sulfate Chemical Structure

CAS No. : 188062-50-2

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10 mM * 1 mL in DMSO
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Based on 3 publication(s) in Google Scholar

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Description

Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir sulfate can inhibits the replication of HIV. Abacavir sulfate shows anticancer activity in prostate cancer cell lines. Abacavir sulfate can trespass the blood-brain-barrier and suppresses telomerase activity[1][2][3].

In Vitro

Abacavir (15 and 150 μM, 0-120 h) sulfate inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines[1].
Abacavir (15 and 150 μM, 18 h) sulfate significantly reduces cell migration and inhibits cell invasion[1].
Abacavir sulfate induces fat apoptosis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Abacavir sulfate Related Antibodies

Cell Proliferation Assay[1]

Cell Line: PC3, LNCaP and WI-38
Concentration: 15 and 150 μM
Incubation Time: 0, 24, 48, 72 and 96 h
Result: Showed a dose-dependent growth inhibition on PC3 and LNCaP.

Cell Cycle Analysis[1]

Cell Line: PC3 and LNCaP
Concentration: 150 μM
Incubation Time: 0, 18, 24, 48, 72, 96 and 120 h
Result: Caused a very high accumulation of cells in S phase in PC3 and LNCaP cells, and G2/M phase increment was observed in PC3 cells.

Cell Migration Assay [1]

Cell Line: PC3 and LNCaP
Concentration: 15 and 150 μM
Incubation Time: 18 h
Result: Significantly reduced cell migration.

Cell Invasion Assay[1]

Cell Line: PC3 and LNCaP
Concentration: 15 and 150 μM
Incubation Time: 18 h
Result: Significantly inhibited cell invision.
In Vivo

Abacavir (0-7.5 μg/mL, 100 μL, intrascrotal administration; 100 and 200 mg/kg, p.o.; 4 h) sulfate dose-dependently promoted thrombus formation[2].
Abacavir (50 mg/kg/d; i.p.; 14 days) sulfate with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J)[2]
Dosage: 2.5, 5 and 7.5 μg/mL, 100 μL or 100 and 200 mg/kg
Administration: Intrascrotal or oral administration for 4 h
Result: Dose-dependently promoted thrombus formation.
Animal Model: NSGTM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma[3]
Dosage: 50 mg/kg/d with 0.1 mg/kg/d Decitabine
Administration: Intraperitoneal injection, daily for 14 days
Result: Inhibited tumor growth and enhanced mouse survival.
Clinical Trial
Molecular Weight

335.38

Formula

C14H18N6O.1/2H2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(O)(O)=O.NC1=NC(NC2CC2)=C3N=CN([C@H]4C=C[C@@H](CO)C4)C3=N1.[1/2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (149.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 33.33 mg/mL (99.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9817 mL 14.9085 mL 29.8169 mL
5 mM 0.5963 mL 2.9817 mL 5.9634 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.45 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.45 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (29.82 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.88%

COA (253 KB) LCMS (273 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.9817 mL 14.9085 mL 29.8169 mL 74.5423 mL
5 mM 0.5963 mL 2.9817 mL 5.9634 mL 14.9085 mL
10 mM 0.2982 mL 1.4908 mL 2.9817 mL 7.4542 mL
15 mM 0.1988 mL 0.9939 mL 1.9878 mL 4.9695 mL
20 mM 0.1491 mL 0.7454 mL 1.4908 mL 3.7271 mL
25 mM 0.1193 mL 0.5963 mL 1.1927 mL 2.9817 mL
30 mM 0.0994 mL 0.4969 mL 0.9939 mL 2.4847 mL
40 mM 0.0745 mL 0.3727 mL 0.7454 mL 1.8636 mL
50 mM 0.0596 mL 0.2982 mL 0.5963 mL 1.4908 mL
60 mM 0.0497 mL 0.2485 mL 0.4969 mL 1.2424 mL
80 mM 0.0373 mL 0.1864 mL 0.3727 mL 0.9318 mL
DMSO 100 mM 0.0298 mL 0.1491 mL 0.2982 mL 0.7454 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Abacavir sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abacavir188062-50-2Abacavir HemisulfateABCReverse TranscriptaseHIVTelomeraseApoptosisHuman immunodeficiency virusprostate cancerPC3LNCaPanticancermedulloblastomaInhibitorinhibitorinhibit

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