2. Immunology/Inflammation
  3. Interleukin Related
  4. IX 207-887

IX 207-887 is a novel antiarthritic agent which inhibits the release of interleukin-1 (IL-1).

For research use only. We do not sell to patients.

IX 207-887 Chemical Structure

IX 207-887 Chemical Structure

CAS No. : 98320-39-9

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10 mM * 1 mL in DMSO
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Customer Review

Based on 1 publication(s) in Google Scholar

IX 207-887 Related Antibodies

Top Publications Citing Use of Products

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • Biological Activity

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  • Customer Review

Description

IX 207-887 is a novel antiarthritic agent which inhibits the release of interleukin-1 (IL-1).

IC50 & Target[1]

IL-2

 

IL-1

 

In Vitro

IX 207-887 is a novel antiarthritic agent which inhibits the release of interleukin-1 (IL-1) from human monocytes and mouse peritoneal macrophages. In all test systems IX 207-887 significantly reduces both biologically active and immunoreactive IL-1 in culture media, whereas the levels of IL-1 in homogenates or lysates are either unaffected or only marginally reduced. IX 207-887 neither affects the adherence of human monocytes nor markedly inhibits IL-1 or IL-2-induced thymocyte proliferation. In the chondrocyte test no IL-1 antagonistic activity of IX 207-887 can be observed[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IX 207-887 Related Antibodies
Molecular Weight

284.33

Formula

C16H12O3S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC(/C=C1C2=C(SC=C2)C(OC)=CC3=C\1C=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (351.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5170 mL 17.5852 mL 35.1704 mL
5 mM 0.7034 mL 3.5170 mL 7.0341 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5170 mL 17.5852 mL 35.1704 mL 87.9260 mL
5 mM 0.7034 mL 3.5170 mL 7.0341 mL 17.5852 mL
10 mM 0.3517 mL 1.7585 mL 3.5170 mL 8.7926 mL
15 mM 0.2345 mL 1.1723 mL 2.3447 mL 5.8617 mL
20 mM 0.1759 mL 0.8793 mL 1.7585 mL 4.3963 mL
25 mM 0.1407 mL 0.7034 mL 1.4068 mL 3.5170 mL
30 mM 0.1172 mL 0.5862 mL 1.1723 mL 2.9309 mL
40 mM 0.0879 mL 0.4396 mL 0.8793 mL 2.1982 mL
50 mM 0.0703 mL 0.3517 mL 0.7034 mL 1.7585 mL
60 mM 0.0586 mL 0.2931 mL 0.5862 mL 1.4654 mL
80 mM 0.0440 mL 0.2198 mL 0.4396 mL 1.0991 mL
100 mM 0.0352 mL 0.1759 mL 0.3517 mL 0.8793 mL
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IX 207-887 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IX 207-88798320-39-9Interleukin RelatedILInhibitorinhibitorinhibit

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