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  6. Heterocyclic Compound Library
Heterocyclic Compound Library

Cat. No.: HY-L138

Heterocyclic compounds are cyclic organic compounds which contain at least one hetero atom, the most common heteroatoms are nitrogen, oxygen ,and sulfur. Heterocycles are common in biology, featuring a wide range of structures from enzyme co-factors to amino acids and proteins. On the one hand, heterocycles are common structural units in approved drugs and in medicinal chemistry targets in the drug discovery process. In addition, heterocycles have been found as a key structure in medical chemistry and also they are frequently found in large percent of biomolecules such as vitamins, natural products ,and biologically active compounds including antifungal, anti-inflammatory, antibacterial, antioxidant, antiallergic, anti-HIV, antidiabetic, anticancer activity.

MCE offers a unique collection of 5,727 heterocyclic compounds which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE heterocyclic compound library is critical for drug discovery and development.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Description & Advantages

•    A unique collection of 5,727 heterocyclic compounds for high throughput screening (HTS) and high content screening (HCS).

•    A useful tool for the study of critical for drug discovery and development.

•    Target diverse, medicinally active and cell permeable.

•    Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•    More detailed compound information with structure, IC50, and other chemical & biological data.

•    High purity and quality validated by NMR and LC/MS.

Product Details

Formulation:

A collection of 5,727 heterocyclic compounds supplied as pre-dissolved Solutions or Solid
Solution: 5,621 compounds supplied in 10 mM solution, 93 compounds supplied in 2 mM solution, 13 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice

Composition

CDK (129)

EGFR (105)

PI3K (79)

VEGFR (78)

HIV (75)

JAK (64)

mAChR (61)

mGluR (51)

FLT3 (50)

nAChR (50)

FGFR (49)

PDGFR (44)

mTOR (42)

HCV (41)

c-Kit (39)

Src (39)

iGluR (35)

Ras (35)

Wnt (35)

PARP (34)

HDAC (33)

Akt (31)

ERK (31)

COX (29)

HSP (29)

ROCK (29)

Raf (28)

MMP (27)

PPAR (27)

Btk (26)

CCR (26)

GSK-3 (24)

CXCR (23)

STAT (23)

PKC (21)

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  •  Specific Compounds
  •  Quantities
  •  Plate Map
  •  Concentration
  •  Form (Solid or Solution)
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    Product Name:
    Heterocyclic Compound Library
    Cat. No.:
    HY-L138
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack

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