Metoprolol tartrate

Name: Metoprolol tartrate
Brand: MedChemExpress
SKU: HY-17503B
Rating: 5.0 (13 reviews)

Cat. No.: HY-17503B Purity: 99.98%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties.

For research use only. We do not sell to patients.

Metoprolol tartrate Chemical Structure

CAS No. : 56392-17-7

Size	Price	Stock	Quantity
10 mg	USD 45	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 13 publication(s) in Google Scholar

Other Forms of Metoprolol tartrate:

Metoprolol succinate In-stock
Metoprolol-d₇ hydrochloride Get quote
Metoprolol-d₆ tartrate Get quote
Metoprolol Get quote
Metoprolol fumarate Get quote
Metoprolol tartrate (Standard) Get quote

13 Publications Citing Use of MCE Metoprolol tartrate

•Preprints. 2023 Jun 19.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Adrenergic Receptor Isoform Specific Products:

View All Isoforms

α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties^[1]^[2]^[3].

IC₅₀ & Target

β1 adrenoceptor

In Vitro

Metoprolol (0-1000 μg/mL; 24-72 h) shows cytotoxic effect on U937 and MOLT-4 cells dose and time dependently^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[3]

Cell Line:	U937 and MOLT-4 cells
Concentration:	1, 10, 50, 100, 500 and 1000 μg/mL
Incubation Time:	24, 48 and 72 h
Result:	Significantly decreased the viability of U937 and MOLT-4 cells at 1000 μg/mL (3740.14µM) concentration after 48 hours incubation time, significantly reduced the viability of U937 cells at ≥500 μg/ml (≥1870.07µM) concentrations after 72 hours incubation time, and significantly decreased the viability of MOLT4 cells at ≥100 μg/ml (≥374.01µM) concentrations after 72 hours incubation.

In Vivo

Metoprolol (2.5 mg/kg/h; infusion; 11 weeks) reduces proinflammatory cytokines and atherosclerosis in ApoE^−/− Mice^[1].
Metoprolol (15 mg/kg/q12h; i.g.; 5 days) shows anti-inflammation and anti-virus effects in murine model with coxsackievirus B3-induced viral myocarditis^[2].
Metoprolol (2.5 mg/kg; i.v.; 3 bolus injections) significantly decreased activated caspase-9 protein expression and inhibits myocardial apoptosis in coronary microembolization (CME) rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ApoE^−/− mice^[1]
Dosage:	2.5 mg/kg/h
Administration:	Via osmotic minipumps, 11 weeks
Result:	Significantly reduced atherosclerotic plaque area in thoracic aorta, reduced serum TNFα and the chemokine CXCL1 as well as decreasing the macrophage content in the plaques.

Animal Model:	Balb/c mice, coxsackievirus B3 (CVB3) induced viral myocarditis (VMC) model^[2]
Dosage:	15 mg/kg/q12h
Administration:	Oral gavage, 5 consecutive days
Result:	Reduced pathological scores of VMC induced by CVB3 infection, protected the myocardium against viral damage by reducing serum cTn-I levels. Decreased the levels of myocardial pro-inflammatory cytokines and increase the expression of anti-inflammatory cytokine. Significantly decreased myocardial virus titers.

Clinical Trial

Molecular Weight

342.41

Formula

C₁₉H₃₁NO₉

CAS No.

56392-17-7

Appearance

Solid

Color

Off-white to light yellow

SMILES

OC(CNC(C)C)COC1=CC=C(CCOC)C=C1.O=C(O)[C@H](O)[C@@H](O)C(O)=O.[0.5]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (365.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (292.05 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9205 mL	14.6024 mL	29.2048 mL
5 mM	0.5841 mL	2.9205 mL	5.8410 mL
10 mM	0.2920 mL	1.4602 mL	2.9205 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.98%

Select Batch:

Data Sheet (280 KB) SDS (623 KB)

COA (250 KB) HNMR (254 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Ulleryd MA, et al. Metoprolol reduces proinflammatory cytokines and atherosclerosis in ApoE-/- mice. Biomed Res Int. 2014;2014:548783. [Content Brief]

[2]. Wang D, et al. Carvedilol has stronger anti-inflammation and anti-virus effects than metoprolol in murine model with coxsackievirus B3-induced viral myocarditis. Gene. 2014 Sep 1;547(2):195-201. [Content Brief]

[3]. Hajatbeigi B, et al. Cytotoxicity of Metoprolol on Leukemic Cells in Vitro. IJBC 2018; 10(4): 124-129.

[4]. Su Q, et al. Effect of metoprolol on myocardial apoptosis and caspase-9 activation after coronary microembolization in rats. Exp Clin Cardiol. 2013 Spring;18(2):161-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.9205 mL	14.6024 mL	29.2048 mL	73.0119 mL
	5 mM	0.5841 mL	2.9205 mL	5.8410 mL	14.6024 mL
	10 mM	0.2920 mL	1.4602 mL	2.9205 mL	7.3012 mL
	15 mM	0.1947 mL	0.9735 mL	1.9470 mL	4.8675 mL
	20 mM	0.1460 mL	0.7301 mL	1.4602 mL	3.6506 mL
	25 mM	0.1168 mL	0.5841 mL	1.1682 mL	2.9205 mL
	30 mM	0.0973 mL	0.4867 mL	0.9735 mL	2.4337 mL
	40 mM	0.0730 mL	0.3651 mL	0.7301 mL	1.8253 mL
	50 mM	0.0584 mL	0.2920 mL	0.5841 mL	1.4602 mL
	60 mM	0.0487 mL	0.2434 mL	0.4867 mL	1.2169 mL
	80 mM	0.0365 mL	0.1825 mL	0.3651 mL	0.9126 mL
	100 mM	0.0292 mL	0.1460 mL	0.2920 mL	0.7301 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.