α adrenergic receptor

α adrenergic receptor Related Products (138):

By Type:	Pan (45) Selective (31)
By Effects:	Inhibitors (23) Agonists (46) Antagonists (59) Modulators (3)

Cat. No.	Product Name	Effect	Purity

HY-13715

Norepinephrine	Agonist	99.43%
Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors.

HY-B0769

Phenylephrine	Agonist	99.94%
(R)-(-)-Phenylephrine is a selective α₁-adrenoceptor agonist primarily used as a decongestant.

HY-B0471

Phenylephrine hydrochloride	Agonist	99.76%
(R)-(-)-Phenylephrine hydrochloride is a selective α₁-adrenoceptor agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-13715A

Norepinephrine hydrochloride	Agonist	99.95%
Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors.

HY-14539

Clozapine	Inhibitor	99.97%
Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a K_i of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with K_is of 9.5 nM and 4 nM, respectively. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC₅₀=11 nM).

HY-162677

MT-1207	Antagonist	99.96%
MT-1207 is an orally active and selective adrenergic α₁ and 5-HT_2A receptor antagonist. MT-1207 shows IC₅₀<0.1 nM, 0.15 nM, 1.40 nM and 0.27 nM for α_1A, α_1B, α_1D and 5-HT_2A, respectively. MT-1207 achieves an effective blood pressure (BP) reduction in the 2K2C rat model without damaging renal function. MT-1207 is a potent multitarget inhibitor with the potential for vasodilatation research.

HY-161836

α2AR agonist 1	Agonist
α2AR agonist 1 (compound S6a), a new morpholine-containing pyrimidinone, acts as an agonist of α2-adrenoceptor. α2AR agonist 1 induces a concentration-dependent relaxation on aortic ring pre-contracted with Phenylephrine (HY-B0769; pEC₅₀=6.81). α2AR agonist 1 increases NOx and NO levels in HUVECs.

HY-158194

α2C adrenoceptor agonist 1	Agonist
α2C adrenoceptor agonist 1 (Compound A) is an orally active, highly selective, and non-central nervous system penetrating agonist for the α2C-adrenoceptor, with EC₅₀ and K_i values of 108 nM and 12 nM, respectively. α2C adrenoceptor agonist 1 can be used in the study of nasal congestion.

HY-B0193A

Prazosin hydrochloride	Antagonist	99.86%
Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders. Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC₅₀ of 0.15 nM.Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC₅₀s of 1.8, and 13 μM, respectively.

HY-13715B

Norepinephrine bitartrate monohydrate	Agonist	99.75%
Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors.

HY-12719

Dexmedetomidine	Agonist	99.93%
Dexmedetomidine ((+)-Medetomidine) is a potent, selective and orally active agonist of α2-adrenoceptor, with a K_i of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects.

HY-17034A

Dexmedetomidine hydrochloride	Agonist	99.93%
Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a K_i of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects.

HY-15746

Dobutamine hydrochloride	Agonist	99.91%
Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.

HY-17416

Guanfacine hydrochloride	Agonist	99.96%
Guanfacine hydrochloride is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD).

HY-121383

Labetalol	Antagonist	99.88%
Labetalol (AH5158) is an orally active selective α1- and non-selective β-adrenergic receptors competitive antagonist. Labetalol, an anti-hypertensive agent, can be used for the research of cardiovascular disease, such as hypertension in pregnancy.

HY-B0661

Tamsulosin	Antagonist	99.77%
Tamsulosin ((R)-(-)-YM12617 free base) is an inhibitor of α₁-adrenergic receptor. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth in animal models.

HY-B0409A

Clonidine hydrochloride	Agonist	99.96%
Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.

HY-12380A

Atipamezole	Antagonist	99.74%
Atipamezole (MPV 1248) is a potent α₂-adrenoceptor antagonist with a K_i of 1.6 nM.

HY-B0659A

Brimonidine tartrate	Agonist	99.14%
Brimonidine tartrate (UK 14304 tartrate) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-B0352

Mirtazapine	Antagonist	99.94%
Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT₂, 5-HT₃, histamine H1 receptor and α2-adrenoceptor antagonist with pK_i values of 8.05, 8.1, 9.3 and 6.95, respectively.

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