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Neurodegenerative Disease-related Compound Library

Cat. No.: HY-L086

Neurodegenerative diseases are incurable and life-threatening conditions that result in progressive degeneration and/or death of nerve cells. Some common neurodegenerative diseases include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Motor Neuron Disease (MND), Huntington’s Disease (HD), Spino-Cerebellar Ataxia (SCA), Spinal Muscular Atrophy (SMA), and Amyotrophic Lateral Sclerosis (ALS). Because the pathophysiology of neurodegenerative disorders is generally poorly understood, it is difficult to identify promising molecular targets and validate them. At the same time, about 85% of the drugs fail in clinical trials. Therefore, validating new targets and discovering new drugs to mitigate neurodegenerative disorders is need of the hour.

MCE offers a unique collection of 2,397 compounds with anti-Neurodegenerative Diseases activities or targeting the unique targets of neurodegenerative diseases. MCE Neurodegenerative Disease-related Compound Library is a useful tool for exploring the mechanism of neurodegenerative diseases and discovering new drugs for neurodegenerative diseases.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Description & Advantages

•   A unique collection of 2,397 compounds for high throughput screening (HTS) and high content screening (HCS).

•   Targets include Amyloid-β, Dopamine Receptor, COMT, LRRK2, 5-HT Receptor, Monoamine Oxidase, nAChR, Histamine Receptor, etc.

•   A useful tool for exploring the mechanism of neurodegenerative diseases and looking for new treatments.

•   Bioactivity and safety confirmed by clinical trials or preclinical research. Some have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Detailed compound information with structure, IC50, and brief introduction.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

Product Details

Formulation:

A collection of 2,397 neurodegenerative disease-related compounds supplied as pre-dissolved Solutions or Solid
Solution: 2,345 compounds supplied in 10 mM solution, 51 compounds supplied in 2 mM solution, 1 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

Composition

iGluR (108)

mAChR (103)

GSK-3 (69)

mGluR (47)

nAChR (44)

ERK (30)

Akt (25)

CDK (24)

LRRK2 (20)

Src (19)

JNK (18)

PARP (14)

PKC (14)

EGFR (13)

Notch (11)

PI3K (11)

VEGFR (11)

c-Kit (10)

PDGFR (10)

AMPK (9)

COMT (9)

COX (9)

HDAC (9)

JAK (9)

PKA (9)

Wnt (9)

STAT (8)

DYRK (7)

FLT3 (7)

MMP (7)

HIV (6)

IKK (6)

mTOR (6)

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    Product Name:
    Neurodegenerative Disease-related Compound Library
    Cat. No.:
    HY-L086
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack

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