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  4. Bismuth subnitrate

Bismuth subnitrate  (Synonyms: Bismuth(III) oxynitrate)

Cat. No.: HY-B2181 Assay: 79.80%
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Bismuth subnitrate (Bismuth(III) oxynitrate) is a simple and efficient catalyst for the synthesis of methyl ketone by martensitic acetylene hydration reaction. When Bismuth subnitrate is intraperitoneally injected into mice, the distribution characteristics of bismuth (Bi) in the brain are similar to those of other exogenous metals such as mercury, silver and gold. Bismuth subnitrate has antibacterial activity, which can inhibit the growth of Staphylococcus aureus and Escherichia coli. Bismuth subnitrate is effective orally and can be used for the study of gastrointestinal diseases, which has protective effect on alcoholic gastric ulcer in rats.

For research use only. We do not sell to patients.

Bismuth subnitrate Chemical Structure

Bismuth subnitrate Chemical Structure

CAS No. : 1304-85-4

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Bismuth subnitrate Related Antibodies

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Description

Bismuth subnitrate (Bismuth(III) oxynitrate) is a simple and efficient catalyst for the synthesis of methyl ketone by martensitic acetylene hydration reaction. When Bismuth subnitrate is intraperitoneally injected into mice, the distribution characteristics of bismuth (Bi) in the brain are similar to those of other exogenous metals such as mercury, silver and gold. Bismuth subnitrate has antibacterial activity, which can inhibit the growth of Staphylococcus aureus and Escherichia coli. Bismuth subnitrate is effective orally and can be used for the study of gastrointestinal diseases, which has protective effect on alcoholic gastric ulcer in rats[1][2][3][4].

In Vitro

Bismuth subnitrate (final concentration 32.5 mg/mL; 37 ℃; 24 h) inhibits the growth of major pathogens of mastitis in vitro, such as Staphylococcus aureus and Escherichia coli[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bismuth subnitrate Related Antibodies
In Vivo

Bismuth subnitrate (2500 mg/kg; Intraperitoneal injection; Single dose) is intraperitoneally injected into mice, the distribution characteristics of bismuth in the brain are similar to those of other exogenous metals such as mercury, silver and gold[3].
Bismuth subnitrate (0.1mL; Oral gavage; Single dose) has protective effect in rat alcoholic gastric ulcer model[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult female Swiss-Webster mice[3]
Dosage: 2500 mg/kg
Administration: Intraperitoneal injection (i.p.); Single dose
Result: Mainly had no effect on the health and activity of the mice, and one mouse showed behavioral signs of neurotoxicity.
Caused ventricles to dilate, loss of the dorsolateral aspects of the septum and thinned the parietal cortex near the dorsal horn of the lateral ventricle.
Placed Bi localization mainly in regions adjacent to blood vessels lacking a blood-brain barrier, subependymal regions, large neurons, cerebellum and sensory nuclei.
Animal Model: Alcohol treated female Wistar rats (180-200 g)[4]
Dosage: 0.1mL (10-15 times the human dose)
Administration: Oral gavage (i.g.); Single dose
Result: Significantly reduced the percentage of gastric ulceration.
Increased the synthesis of prostaglandin E2.
Molecular Weight

1461.99

Formula

Bi5H9N4O22
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[Bi]([Bi]([Bi](O)(O[N+]([O-])=O)(O[N+]([O-])=O)O)[Bi](O)(O[N+]([O-])=O)(O[N+]([O-])=O)O)([Bi](O)(O)(O)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (13.68 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 1 mg/mL (0.68 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6840 mL 3.4200 mL 6.8400 mL
5 mM 0.1368 mL 0.6840 mL 1.3680 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 1.11 mg/mL (0.76 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.11 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (11.1 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥97.0%

SDS (609 KB)

COA (306 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6840 mL 3.4200 mL 6.8400 mL 17.1000 mL
5 mM 0.1368 mL 0.6840 mL 1.3680 mL 3.4200 mL
10 mM 0.0684 mL 0.3420 mL 0.6840 mL 1.7100 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Bismuth subnitrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bismuth subnitrate1304-85-4Bismuth(III) oxynitrateBacterialBismuth compoundAntidiarrheic agentCatalystAntibioticGastric ulcer modelInhibitorinhibitorinhibit

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