HCN3 - hyperpolarization activated cyclic nucleotide gated potassium channel 3 Gene

Homo sapiens

Gene ID: 57657 | Gene type: protein coding

About HCN3

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,277,463-155,289,848 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 343 orthologues and 17 paralogues. Ubiquitous expression in liver (RPKM 3.6), duodenum (RPKM 2.6) and 25 other tissues.

Summary

This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

HCN3 Products(1)

mRNA	Protein	Name
NM_020897.3	NP_065948.1	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26966193	GOA
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	16043489	GOA
enables voltage-gated potassium channel activity	IMP IMP: Inferred from mutant phenotype	22748890	GOA
enables voltage-gated sodium channel activity	IDA IDA: Inferred from direct assay	16043489	GOA
enables voltage-gated sodium channel activity	IMP IMP: Inferred from mutant phenotype	22748890	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in cellular response to cAMP	IDA IDA: Inferred from direct assay	22748890	GOA
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	16043489	GOA
involved in potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	22748890	GOA
involved in regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	22748890	GOA
involved in sodium ion transmembrane transport	IDA IDA: Inferred from direct assay	16043489	GOA
involved in sodium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	22748890	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	22748890	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HCN3 Protein Structure

Ion_trans_N

Ion_trans

cNMP_binding

0
200
400
600
774 a.a.

Protein Preferred Names

Protein Names

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Related Diseases

Diseases

Alias

Bladder Neck Obstruction

Obstruction Of Bladder Neck Or Vesicourethral Orifice	Urinary Bladder Neck Obstruction
Bladder Outlet Obstruction	Vesicourethral Orifice Obstruction
Bno - [Bladder Neck Obstruction]	Bladder Obstruction Nos
Acquired Bladder Neck Obstruction	Acquired Obstruction Of Bladder Neck Or Vesicourethral Orifice
Bladder Neck Strangulation	Bladder Neck Stricture
Bladder Outflow Obstruction	Contracture Of Bladder Neck Or Sphincter
Contracture Of Bladder Neck	Obstructed Vesicourethral Orifice
Strangulation Of Vesicourethral Orifice	Stricture Of Vesicourethral Orifice
Urinary Prostatic Valve Obstruction	Vesical Obstruction

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-18940	Cilobradine		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13422	Zatebradine hydrochloride	Antagonist	99.06%	Unkown
HY-13422A	Zatebradine	Antagonist	99.27%	Unkown
HY-160505	RO-275	Inhibitor	≥99.0%	Unkown
HY-RS06048	HCN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HCN3	VGNC	VGNC:41621
Bos taurus	HCN3	VGNC	VGNC:29778
Mus musculus	HCN3	MGD	MGI:1298211
Macaca mulatta	HCN3	VGNC	VGNC:106379
Rattus norvegicus	HCN3	RGD	RGD:620691

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