1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Acetyl-CoA synthetase

Acetyl-CoA synthetase

Acs

Acetyl-Coenzyme A synthetase (Acs) is a key enzyme that catalyzes the conversion of acetate to acetyl-CoA (Ac-CoA). As a crucial enzyme in the Wood-Ljungdahl pathway of carbon fixation, acetyl-CoA synthetase has bifunctional roles, using a nickel-containing bimetallic site to combine carbon monoxide with a methyl group, ultimately converting it into acetyl-CoA. Acetyl-CoA is essential in metabolism and energy generation. The activity of ACS is tightly regulated by complex systems, including carbon flux-mediated gene expression and post-translational regulation via the NAD+/sirtuin-dependent pathway.
Acetyl-CoA synthetase can induce Autophagy, and its mediated histone acetylation plays a significant role in maintaining cellular homeostasis and tumor development[1][2][3].

Acetyl-CoA synthetase Related Products (2):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-148104
    ACSS2-IN-2
    Inhibitor 99.49%
    ACSS2-IN-2 is an acyl-CoA synthetase short-chain family member 2 (ACSS2) inhibitor. ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several diseases, such as viral infection, metabolic disorders, neuropsychiatric diseases, inflammatory/autoimmune conditions and cancer.
    ACSS2-IN-2
  • HY-W712674
    HMG-CoA
    HMG-CoA is a product generated by the hydration reaction of (E)-3-methylglutaconyl-CoA (MG-CoA) catalyzed by methylglutaconyl-CoA hydratase (MGCH).
    HMG-CoA