Acetyl-CoA synthetase

Acs

Acetyl-Coenzyme A synthetase (Acs) is a key enzyme that catalyzes the conversion of acetate to acetyl-CoA (Ac-CoA). As a crucial enzyme in the Wood-Ljungdahl pathway of carbon fixation, acetyl-CoA synthetase has bifunctional roles, using a nickel-containing bimetallic site to combine carbon monoxide with a methyl group, ultimately converting it into acetyl-CoA. Acetyl-CoA is essential in metabolism and energy generation. The activity of ACS is tightly regulated by complex systems, including carbon flux-mediated gene expression and post-translational regulation via the NAD+/sirtuin-dependent pathway.
Acetyl-CoA synthetase can induce Autophagy, and its mediated histone acetylation plays a significant role in maintaining cellular homeostasis and tumor development^[1]^[2]^[3].

References:

[1]. Hegg EL. Unraveling the structure and mechanism of acetyl-coenzyme A synthase. Acc Chem Res. 2004 Oct;37(10):775-83. [Content Brief]

[2]. Li X, et al. Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. Mol Cell. 2017 Jun 1;66(5):684-697.e9. [Content Brief]

[3]. Starai VJ, et al. Acetyl-coenzyme A synthetase (AMP forming). Cell Mol Life Sci. 2004 Aug;61(16):2020-30. [Content Brief]

Acetyl-CoA synthetase Inhibitor (1)

Acetyl-CoA synthetase Related Products (1):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-148104

ACSS2-IN-2	Inhibitor	98.06%
ACSS2-IN-2 is an acyl-CoA synthetase short-chain family member 2 (ACSS2) inhibitor. ACSS2-IN-2 can inhibit ACSS2 activity with an IC₅₀ value of 3.8 nM. ACSS2-IN-2 can be used for the research of several diseases, such as viral infection, metabolic disorders, neuropsychiatric diseases, inflammatory/autoimmune conditions and cancer.

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