TMPRSS2 - transmembrane serine protease 2 Gene

Homo sapiens

Also known as PRSS10

Gene ID: 7113 | Gene type: protein coding

About TMPRSS2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:41,464,305-41,508,158 (from NCBI)

This gene has 20 transcripts (splice variants), 229 orthologues, 17 paralogues and is associated with 72 phenotypes. Biased expression in prostate (RPKM 167.2), colon (RPKM 59.9) and 10 other tissues.

Summary

This gene encodes a protein that belongs to the serine Protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a Protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic Hormones in prostate Cancer cells and down-regulated in androgen-independent prostate Cancer tissue. The Protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza Virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]

TMPRSS2 Products(3)

mRNA	Protein	Name
NM_001135099.1	NP_001128571.1	transmembrane protease serine 2 isoform 1
NM_001382720.1	NP_001369649.1	transmembrane protease serine 2 isoform 3
NM_005656.4	NP_005647.3	transmembrane protease serine 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21068237	GOA
enables serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	25122198	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	21068237	GOA
involved in protein autoprocessing	IMP IMP: Inferred from mutant phenotype	21068237	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	21068237	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	21068237	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMPRSS2 Protein Structure

SRCR_2

Trypsin

0
100
200
300
400
500
529 a.a.

Protein Preferred Names

Protein Names

transmembrane protease serine 2

epitheliasin

Recombinant TMPRSS2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72043	TMPRSS2 Protein, Human (P.pastoris, His)	O15393 (W106-G492)	≥95%
HY-P72044	TMPRSS2 Protein, Human (R255Q, HEK293, His)	O15393-1 (W106-G492, R255Q)	≥95%

Related Diseases

Diseases

Alias

Covid-19

2019 Novel Coronavirus	2019-Ncov Infection
Covid19	Sars-Cov-2 Infection
Wuhan Coronavirus Infection	Wuhan Seafood Market Pneumonia Virus Infection

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Middle East Respiratory Syndrome

Mers	Mers - [Middle East Respiratory Syndrome]

Severe Acute Respiratory Syndrome

Sars	Sars-Cov Infection
Sars-1	Sar Deficiency
Sars - [Severe Acute Respiratory Syndrome]

Coronavirus Infectious Disease

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Long Covid

Post-Acute Sequelae Of Sars-Cov-2 Infection	Chronic Covid-19
Pasc	Post-Covid Syndrome

Critical Covid-19

Acute Hemorrhagic Conjunctivitis

Viral Conjunctivitis	Conjunctivitis, Acute Hemorrhagic
Apollo Disease	Epidemic Hemorrhagic Conjunctivitis
Viral Conjunctiva Disorder	Viral Conjunctivitis Nos

Severe Covid-19

Viral Pneumonia

Pneumonia, Viral	Acute Viral Pneumonia
Bronchopneumonia Due To Viruses Other Than Influenza Viruses	Interstitial Viral Pneumonia
Viral Bronchopneumonia	Viral Double Pneumonia
Viral Lobar Pneumonia	Viral Purulent Pneumonia
Virus Interstitial Pneumonia	Virus Lobar Pneumonia

Ebola Hemorrhagic Fever

Ebola Virus Disease	Viral Hemorrhagic Fever
Hemorrhagic Fever, Ebola	Ebola
Ehf	Ebola Fever
Hemorrhagic Fevers, Viral	Ebola Haemorrhagic Fever
Ebod - [Ebola Disease]	Evd - [Ebola Virus Disease]
Ebola Virus Haemorrhagic Fever	Vhf - [Viral Haemorrhagic Fever] Nos
Viral Haemorrhagic Fever, Not Otherwise Specified

Non-Severe Covid-19

Orchitis

Inflammation Of Testis	Orchititis
Mumps Orchitis

Androgenic Alopecia

Androgenetic Alopecia

Alopecia Androgenetica, Male Pattern Baldness

Prostatic Acinar Adenocarcinoma

Acinar Prostate Adenocarcinoma

Avian Influenza

Bird Flu	Influenza In Birds
Avian Flu

Miller Fisher Syndrome

Cranial Variant Of Gbs	Fisher'S Syndrome
Miller-Fisher Variant Of Guillain-Barre Syndrome	Miller-Fisher Syndrome
Cranial Variant Of Guillain-Barré Syndrome	Cranial Variant Of Guillain-Barre Syndrome
Fisher Syndrome

Prostate Neuroendocrine Neoplasm

Neuroendocrine Tumor Of The Prostate

Peptic Esophagitis

Reflux Esophagitis	Peptic Reflux Disease
Reflux Oesophagitis	Esophagitis, Peptic
Gastro-Esophageal Reflux Disease With Esophagitis

Subacute Thyroiditis

Giant-Cell Thyroiditis	Granulomatous Thyroiditis
Subacute Granulomatous Thyroiditis	De Quervain'S Thyroiditis
Thyroiditis Subacute	Thyroiditis, Subacute
Pseudogranulomatous Thyroiditis	De Quervain Thyroiditis
Nonsuppurative Subacute Thyroiditis	Pseudotuberculous Thyroiditis
Nonsuppurative Thyroiditis Nos

Common Cold

Acute Coryza	Acute Nasopharyngitis
Acute Rhinitis	Acute Viral Rhinopharyngitis
Nasopharyngitis - Acute	Nasopharyngitis, Acute
Rhino-Sinusitis	Rhinosinusitis
Common Colds	Acute Infective Rhinitis
Cold	Coryza
Head Cold	Infective Nasopharyngitis
Rhinopharyngitis	Acute Nasal Catarrh
Infective Rhinitis	Acute Nasopharyngeal Catarrh
Infective Nasopharyngitis Nos	Nasopharyngitis Nos
Epipharyngitis	Mucositis Nos
Inflammatory Disease Of Mucous Membrane	Mucosal Inflammation

Conjunctival Disease

Conjunctival Diseases

Conjunctival Disorder

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma	Adenocarcinoma Of Prostate
ST12	Prostate Adenocarcinoma 1
Pac1

Herpangina

Vesicular Pharyngitis

Acute Dacryoadenitis

Adult Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome	Ards
Non-Cardiogenic Pulmonary Edema	Acute Lung Injury
Respiratory Distress Syndrome, Adult	Shock Lung
Acute Respiratory Distress	Respiratory Distress Syndrome
Adult Rds	Ali
Increased-Permeability Pulmonary Edema	Stiff Lung
Respiratory Distress Syndrome Adult

Pulmonary Artery Disease

Abnormality Of The Pulmonary Artery

Respiratory Failure

Acute Respiratory Failure	Chronic Respiratory Failure
Respiratory Insufficiency	Acute-On-Chronic Respiratory Failure
Respiratory Disease	Acute And Chronic Respiratory Failure
Respiratory Insufficiency/Failure	Chronic Respiratory Disease
Pulmonary Valve Insufficiency	Chronic Disease Of Respiratory System
Respiration Disorders	Respiratory Tract Diseases
Lung Failure Nos	Pulmonary Failure
Arf - [Acute Respiratory Failure]	Acute Respiratory Insufficiency
Acute Pulmonary Insufficiency	Acute Respiration Failure
Chronic Respiration Failure

Extrinsic Cardiomyopathy

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Anomaly
Coronary Artery Disease, Susceptibility To	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13512	Camostat mesylate	Inhibitor	99.93%	Unkown
HY-B0372A	Bromhexine hydrochloride		99.84%	Unkown
HY-B1624A	Debrisoquin hemisulfate		99.94%	Unkown

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135794	11-Ketodihydrotestosterone	Agonist	98.03%	Unkown
HY-15290	AIM-100	Inhibitor	99.95%	Unkown
HY-134432B	Boc-Gln-Ala-Arg-AMC acetate		99.96%	Unkown
HY-148072	MM3122	Inhibitor	99.20%	Unkown
HY-108447	BC-11 hydrobromide	Inhibitor	≥99.0%	Unkown
HY-157154	MAT-POS-e194df51-1	Inhibitor	/	Unkown
HY-B0372AS	Bromhexine-d3 hydrochloride		≥99.0%	Unkown
HY-W195509	Debrisoquin hydroiodide	Inhibitor	99.84%	Unkown
HY-105747A	Guanoxyfen nitrate		/	Unkown
HY-130402B	Propamidine		/	Unkown
HY-134432A	Boc-Gln-Ala-Arg-AMC hydrochloride		/	Unkown
HY-156441	SARS-CoV-2-IN-65	Inhibitor	/	Unkown
HY-157021	SARS-CoV-2-IN-66	Inhibitor	/	Unkown
HY-158073	ML2006a4	Inhibitor	/	Unkown
HY-161370	VD4162	Inhibitor	/	Unkown
HY-161902	MI-1904	Inhibitor	/	Unkown
HY-162719	RH12	Inhibitor	/	Unkown
HY-RS14769	TMPRSS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-157022	SARS-CoV-2-IN-67	Inhibitor	/	Unkown
HY-162604	SARS-CoV-2-IN-90	Inhibitor	/	Unkown
HY-163029	CTSL/B-IN-1	Inhibitor	/	Unkown
HY-163067	SARS-CoV-2-IN-71	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TMPRSS2	VGNC	VGNC:78575
Canis familiaris	TMPRSS2	VGNC	VGNC:53045
Bos taurus	TMPRSS2	VGNC	VGNC:36140
Felis catus	TMPRSS2	VGNC	VGNC:66385
Mus musculus	TMPRSS2	MGD	MGI:1354381
Others	TMPRSS2	NCBI