2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Debrisoquin hemisulfate

Debrisoquin hemisulfate  (Synonyms: Debrisoquine hemisulfate; Isocaramidine hemisulfate; Ro 5-3307/1 hemisulfate)

Cat. No.: HY-B1624A Purity: 99.94%
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Debrisoquin (Isocaramidine) hemisulfate is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin hemisulfate can be used for antiviral research.

For research use only. We do not sell to patients.

Debrisoquin hemisulfate Chemical Structure

Debrisoquin hemisulfate Chemical Structure

CAS No. : 581-88-4

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5 mg USD 43 In-stock
10 mg USD 70 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Debrisoquin (Isocaramidine) hemisulfate is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin hemisulfate can be used for antiviral research[1].

IC50 & Target

Human Endogenous Metabolite

 

Clinical Trial
Molecular Weight

224.27

Formula

C10H13N3.1/2H2O4S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=S(O)(O)=O.N=C(N1CC2=C(CC1)C=CC=C2)N.[1/2]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 10.42 mg/mL (46.46 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4589 mL 22.2946 mL 44.5891 mL
5 mM 0.8918 mL 4.4589 mL 8.9178 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Animal weight
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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.4589 mL 22.2946 mL 44.5891 mL 111.4728 mL
5 mM 0.8918 mL 4.4589 mL 8.9178 mL 22.2946 mL
10 mM 0.4459 mL 2.2295 mL 4.4589 mL 11.1473 mL
15 mM 0.2973 mL 1.4863 mL 2.9726 mL 7.4315 mL
20 mM 0.2229 mL 1.1147 mL 2.2295 mL 5.5736 mL
25 mM 0.1784 mL 0.8918 mL 1.7836 mL 4.4589 mL
30 mM 0.1486 mL 0.7432 mL 1.4863 mL 3.7158 mL
40 mM 0.1115 mL 0.5574 mL 1.1147 mL 2.7868 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Debrisoquin hemisulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Debrisoquin hemisulfate581-88-4Debrisoquine hemisulfateIsocaramidine hemisulfateRo 5-3307/1 hemisulfateEndogenous MetaboliteSARS-CoVinfectionCalu-3 cellshuman lung cell lineTMPRSS2 inhibitorsInhibitorinhibitorinhibit

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