2. Protein Tyrosine Kinase/RTK
  3. Ephrin Receptor
  4. LDN-211904

LDN-211904 is an inhibitor of EphB3 receptor tyrosine kinase. LDN-211904 enhances the inhibitory activity of EphB3 kinase by maintaining the 2-chloroaniline group and introducing a phenyl or small electron donor substituent to the 5 position of pyrazole and [1,5-a] pyridine. LDN-211904 can be used as a molecular probe to study the function and signaling pathways of EphB3 receptors, especially in the nervous system during neurodevelopment and adulthood.

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LDN-211904 Chemical Structure

LDN-211904 Chemical Structure

CAS No. : 1198408-39-7

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Description

LDN-211904 is an inhibitor of EphB3 receptor tyrosine kinase. LDN-211904 enhances the inhibitory activity of EphB3 kinase by maintaining the 2-chloroaniline group and introducing a phenyl or small electron donor substituent to the 5 position of pyrazole and [1,5-a] pyridine. LDN-211904 can be used as a molecular probe to study the function and signaling pathways of EphB3 receptors, especially in the nervous system during neurodevelopment and adulthood[1].

Molecular Weight

354.83

Formula

C19H19ClN4O
CAS No.
SMILES

O=C(C1=CN=C2C=CC(C3CCNCC3)=CN21)NC4=C(Cl)C=CC=C4
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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LDN-211904 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LDN-2119041198408-39-7LDN211904LDN 211904Ephrin ReceptorInhibitormolecular probesneurodevelopmentEphB3inhibitorinhibit

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