2. Protein Tyrosine Kinase/RTK
  3. Ephrin Receptor
  4. LDN-211904 oxalate

LDN-211904 oxalate (compound 32) is a potent and selective EphB3 inhibitor with an IC50 of 0.079 µM. LDN-211904 oxalate shows good metabolic stability in mouse liver microsomes. LDN-211904 oxalate with cetuximab could be effective in inhibiting STAT3-activated CSC stemness and cetuximab resistance in CRC.

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LDN-211904 oxalate Chemical Structure

LDN-211904 oxalate Chemical Structure

CAS No. : 1198408-78-4

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Based on 1 publication(s) in Google Scholar

Other Forms of LDN-211904 oxalate:

LDN-211904 oxalate Related Antibodies

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Description

LDN-211904 oxalate (compound 32) is a potent and selective EphB3 inhibitor with an IC50 of 0.079 µM. LDN-211904 oxalate shows good metabolic stability in mouse liver microsomes. LDN-211904 oxalate with cetuximab could be effective in inhibiting STAT3-activated CSC stemness and cetuximab resistance in CRC[1][2].

IC50 & Target

IC50: 0.079 µM (EphB3)[1]
Molecular Weight

444.87

Formula

C21H21ClN4O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(O)=O)O.O=C(C1=CN=C2C=CC(C3CCNCC3)=CN21)NC4=C(Cl)C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (44.96 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2478 mL 11.2392 mL 22.4785 mL
5 mM 0.4496 mL 2.2478 mL 4.4957 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2478 mL 11.2392 mL 22.4785 mL 56.1962 mL
5 mM 0.4496 mL 2.2478 mL 4.4957 mL 11.2392 mL
10 mM 0.2248 mL 1.1239 mL 2.2478 mL 5.6196 mL
15 mM 0.1499 mL 0.7493 mL 1.4986 mL 3.7464 mL
20 mM 0.1124 mL 0.5620 mL 1.1239 mL 2.8098 mL
25 mM 0.0899 mL 0.4496 mL 0.8991 mL 2.2478 mL
30 mM 0.0749 mL 0.3746 mL 0.7493 mL 1.8732 mL
40 mM 0.0562 mL 0.2810 mL 0.5620 mL 1.4049 mL
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LDN-211904 oxalate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LDN-2119041198408-78-4LDN211904LDN 211904Ephrin Receptormetabolic stabilitySW48R tumor cellsCSC stemnessCRCInhibitorinhibitorinhibit

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