2. Academic Validation
  3. Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria

Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria

  • Org Biomol Chem. 2013 Jul 7;11(25):4147-53. doi: 10.1039/c3ob40489g.
Marie-Céline Frantz 1,  Erin M Skoda,  Joshua R Sacher,  Michael W Epperly,  Julie P Goff,  Joel S Greenberger,  Peter Wipf
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
PMID: 23715589 DOI: 10.1039/c3ob40489g
Abstract

JP4-039 is a lead structure in a series of nitroxide conjugates that are capable of accumulating in mitochondria and scavenging Reactive Oxygen Species (ROS). To explore structure-activity relationships (SAR), new analogs with variable nitroxide moieties were prepared. Furthermore, fluorophore-tagged analogs were synthesized and provided the opportunity for visualization in mitochondria. All analogs were tested for radioprotective and radiomitigative effects in 32Dcl3 cells.

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