2. Academic Validation
  3. Fermentation, isolation, characterization and structure of antibiotic U-58,431

Fermentation, isolation, characterization and structure of antibiotic U-58,431

  • J Antibiot (Tokyo). 1980 Sep;33(9):919-23. doi: 10.7164/antibiotics.33.919.
L Slechta,  C G Chidester,  F Reusser
PMID: 7440414 DOI: 10.7164/antibiotics.33.919
Abstract

A new Antibiotic U-58,431 has been isolated from the fermentation broth of Streptomyces helicus DIETZ and LI, sp. n. (UC-5837) and the structure of this Antibiotic, namely, 6-amino-3,4,5,8-tetrahydro-4,9-dihydroxy-3-methyl-5,8-dioxo-1,4-ethano-1H-2-benzopyron-7-carboxamide has been determined by X-ray crystallography. The Antibiotic inhibits a variety of Gram-positive and Gram-negative bacteria in vitro. However, it is toxic to mice and does not protect experimentally infected Animals when administered at the maximum tolerated dose.

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