2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. PD 174265

PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR with an IC50 of 450 pM.

For research use only. We do not sell to patients.

PD 174265 Chemical Structure

PD 174265 Chemical Structure

CAS No. : 216163-53-0

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1 mg USD 25 In-stock
5 mg USD 50 In-stock
10 mg USD 80 In-stock
25 mg USD 135 In-stock
50 mg USD 190 In-stock
100 mg USD 265 In-stock
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Based on 1 publication(s) in Google Scholar

PD 174265 Related Antibodies

Top Publications Citing Use of Products

View All EGFR Isoform Specific Products:

View All Isoforms
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR with an IC50 of 450 pM[1].

Molecular Weight

371.23

Formula

C17H15BrN4O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CCC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (336.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6937 mL 13.4687 mL 26.9375 mL
5 mM 0.5387 mL 2.6937 mL 5.3875 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6937 mL 13.4687 mL 26.9375 mL 67.3437 mL
5 mM 0.5387 mL 2.6937 mL 5.3875 mL 13.4687 mL
10 mM 0.2694 mL 1.3469 mL 2.6937 mL 6.7344 mL
15 mM 0.1796 mL 0.8979 mL 1.7958 mL 4.4896 mL
20 mM 0.1347 mL 0.6734 mL 1.3469 mL 3.3672 mL
25 mM 0.1077 mL 0.5387 mL 1.0775 mL 2.6937 mL
30 mM 0.0898 mL 0.4490 mL 0.8979 mL 2.2448 mL
40 mM 0.0673 mL 0.3367 mL 0.6734 mL 1.6836 mL
50 mM 0.0539 mL 0.2694 mL 0.5387 mL 1.3469 mL
60 mM 0.0449 mL 0.2245 mL 0.4490 mL 1.1224 mL
80 mM 0.0337 mL 0.1684 mL 0.3367 mL 0.8418 mL
100 mM 0.0269 mL 0.1347 mL 0.2694 mL 0.6734 mL
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PD 174265 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD 174265216163-53-0PD174265PD-174265EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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