PD 174265

Cat. No.: HY-112411 Purity: 98.72%: FAQs
Data Sheet SDS COA Handling Instructions

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PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR with an IC₅₀ of 450 pM.

For research use only. We do not sell to patients.

PD 174265 Chemical Structure

CAS No. : 216163-53-0

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 135	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 265	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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View All Isoforms

EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

Biological Activity
Purity & Documentation
References
Customer Review

Description

PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR with an IC₅₀ of 450 pM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	GI₅₀	0.021 μM Compound: PD-168393	Growth inhibition of human A431 cells after 72 hrs by MTT assay Growth inhibition of human A431 cells after 72 hrs by MTT assay	[PMID: 19969465]
BaF3	GI₅₀	< 0.5 μM Compound: 3d	Growth inhibition of mouse BA/F3 cells expressing EGFR Del1 mutant after 96 hrs by cell titer-glo assay Growth inhibition of mouse BA/F3 cells expressing EGFR Del1 mutant after 96 hrs by cell titer-glo assay	[PMID: 20222733]
BaF3	GI₅₀	< 0.5 μM Compound: 3d	Growth inhibition of mouse BA/F3 cells expressing EGFR Del3 mutant after 96 hrs by cell titer-glo assay Growth inhibition of mouse BA/F3 cells expressing EGFR Del3 mutant after 96 hrs by cell titer-glo assay	[PMID: 20222733]
BaF3	GI₅₀	< 0.5 μM Compound: 3d	Growth inhibition of mouse BA/F3 cells expressing EGFR Del5 mutant after 96 hrs by cell titer-glo assay Growth inhibition of mouse BA/F3 cells expressing EGFR Del5 mutant after 96 hrs by cell titer-glo assay	[PMID: 20222733]
BaF3	GI₅₀	< 0.5 μM Compound: 3d	Growth inhibition of mouse BA/F3 cells expressing EGFR L858R mutant after 96 hrs by cell titer-glo assay Growth inhibition of mouse BA/F3 cells expressing EGFR L858R mutant after 96 hrs by cell titer-glo assay	[PMID: 20222733]
BaF3	GI₅₀	> 0.5 μM Compound: 3d	Growth inhibition of mouse BA/F3 cells expressing EGFR Del3 and Thr790Met mutant after 96 hrs by cell titer-glo assay Growth inhibition of mouse BA/F3 cells expressing EGFR Del3 and Thr790Met mutant after 96 hrs by cell titer-glo assay	[PMID: 20222733]
BaF3	GI₅₀	> 5 μM Compound: 3d	Growth inhibition of mouse BA/F3 cells expressing EGFR Del1 and Thr790Met mutant after 96 hrs by cell titer-glo assay Growth inhibition of mouse BA/F3 cells expressing EGFR Del1 and Thr790Met mutant after 96 hrs by cell titer-glo assay	[PMID: 20222733]
BaF3	GI₅₀	> 5 μM Compound: 3d	Growth inhibition of mouse BA/F3 cells expressing EGFR Del5 and Thr790Met mutant after 96 hrs by cell titer-glo assay Growth inhibition of mouse BA/F3 cells expressing EGFR Del5 and Thr790Met mutant after 96 hrs by cell titer-glo assay	[PMID: 20222733]
BaF3	GI₅₀	> 5 μM Compound: 3d	Growth inhibition of mouse BA/F3 cells expressing EGFR L858R and Thr790Met mutant after 96 hrs by cell titer-glo assay Growth inhibition of mouse BA/F3 cells expressing EGFR L858R and Thr790Met mutant after 96 hrs by cell titer-glo assay	[PMID: 20222733]

Molecular Weight

371.23

Formula

C₁₇H₁₅BrN₄O

CAS No.

216163-53-0

Appearance

Solid

Color

Light yellow to yellow

SMILES

CCC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (336.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6937 mL	13.4687 mL	26.9375 mL
5 mM	0.5387 mL	2.6937 mL	5.3875 mL
10 mM	0.2694 mL	1.3469 mL	2.6937 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.72%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (247 KB) HNMR (253 KB) LCMS (265 KB)

Handling Instructions (2659 KB)

References

[1]. Fry DW, et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12022-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6937 mL	13.4687 mL	26.9375 mL	67.3437 mL
	5 mM	0.5387 mL	2.6937 mL	5.3875 mL	13.4687 mL
	10 mM	0.2694 mL	1.3469 mL	2.6937 mL	6.7344 mL
	15 mM	0.1796 mL	0.8979 mL	1.7958 mL	4.4896 mL
	20 mM	0.1347 mL	0.6734 mL	1.3469 mL	3.3672 mL
	25 mM	0.1077 mL	0.5387 mL	1.0775 mL	2.6937 mL
	30 mM	0.0898 mL	0.4490 mL	0.8979 mL	2.2448 mL
	40 mM	0.0673 mL	0.3367 mL	0.6734 mL	1.6836 mL
	50 mM	0.0539 mL	0.2694 mL	0.5387 mL	1.3469 mL
	60 mM	0.0449 mL	0.2245 mL	0.4490 mL	1.1224 mL
	80 mM	0.0337 mL	0.1684 mL	0.3367 mL	0.8418 mL
	100 mM	0.0269 mL	0.1347 mL	0.2694 mL	0.6734 mL

PD 174265 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD 174265216163-53-0PD174265PD-174265EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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PD 174265

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PD 174265 Related Antibodies

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View All EGFR Isoform Specific Products:

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Purity & Documentation

References

Customer Review

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Complete Stock Solution Preparation Table

PD 174265 Related Classifications

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