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β-Lactamase-IN-1

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By Targets:	Beta-lactamase (14) Antibiotic (10) Bacterial (19) Bcl-2 Family (1) CFTR (2) Complement System (1) Drug Intermediate (1) HIV (1) iGluR (2) Isotope-Labeled Compounds (1) Melanocortin Receptor (6) PACAP Receptor (1) Parasite (1) Penicillin-binding protein (PBP) (2) Phospholipase (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Endocrinology (1) Infection (18) Inflammation/Immunology (5) Metabolic Disease (3) Neurological Disease (5)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Beta-lactamase Dan family AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19773

β-Lactamase-IN-1	Beta-lactamase Bacterial	Infection
β-Lactamase-IN-1 is an inhibitor of *β-Lactamase* extracted from patent WO2016027249A1, page 77. β-Lactamase-IN-1 can be used to prepare of tricyclic nitrogen containing compound. β-Lactamase-IN-1 can be used for the research of neisseria gonorrhea infection ^[1].

HY-136306

*Metallo β-lactamase* ligand 1**	Beta-lactamase Bacterial	Infection
Metallo-beta-lactamase ligand 1 is a class B *β-lactamase* inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A ^[1].

HY-12826

IMB-XH1	Beta-lactamase Bcl-2 Family Bacterial	Cancer
IMB-XH1 is an inhibitor of myeloid cell factor 1 (Mcl-1) ^[1]. IMB-XH1 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC₅₀s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively .

HY-120859

Zidebactam 5+ Cited Publications WCK-5107	Beta-lactamase Penicillin-binding protein (PBP) Bacterial	Infection
Zidebactam (WCK-5107) is a potent β-lactamase inhibitor ^[1]. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC₅₀ of 0.26 μg/mL .

HY-B1434

7-Aminocephalosporanic acid 1 Publications Verification 7-ACA	Beta-lactamase Bacterial Antibiotic	Infection
7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor ^[1] .

HY-14879A

Avibactam sodium Maximum Cited Publications 67 Publications Verification NXL-104	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase *TEM-1* and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively ^[1].

HY-14879B

Avibactam sodium hydrate Maximum Cited Publications 67 Publications Verification NXL-104 hydrate	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase *TEM-1* and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively ^[1].

HY-14879

Avibactam free acid Maximum Cited Publications 67 Publications Verification NXL-104 free acid	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase *TEM-1* and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively ^[1].

HY-120859A

Zidebactam sodium salt WCK-5107 sodium salt	Beta-lactamase Penicillin-binding protein (PBP) Bacterial	Infection
Zidebactam sodium salt (WCK-5107 sodium salt) is a potent β-lactamase inhibitor ^[1]. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC₅₀ of 0.26 μg/mL .

HY-14879C

Avibactam sodium dihydrate NXL-104 dihydrate	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam sodium (NXL-104) dihydrate is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase *TEM-1* and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively ^[1].

HY-B1434R

7-Aminocephalosporanic acid (Standard)	Beta-lactamase Bacterial Antibiotic	Infection
7-Aminocephalosporanic acid (Standard) is the analytical standard of 7-Aminocephalosporanic acid. This product is intended for research and analytical applications. 7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor ^[1] .

HY-14879AR

Avibactam (sodium) (Standard)	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam (sodium) (Standard) is the analytical standard of Avibactam (sodium). This product is intended for research and analytical applications. Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase *TEM-1* and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively ^[1].

HY-14879S2

Avibactam sodium salt-13C5 NXL-104-¹³C₅	Isotope-Labeled Compounds Antibiotic Beta-lactamase Bacterial	Infection
Avibactam sodium salt- ¹³C₅ (NXL-104- ¹³C₅) is ¹³C labeled Avibactam (sodium). Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase *TEM-1* and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively ^[1] .

HY-146637

VIM-2-IN-1	Beta-lactamase Bacterial	Infection
VIM-2-IN-1 (compound 1dj) is a *β-lactamase* inhibitor with antibacterial activities. VIM-2-IN-1 has moderate IC₅₀ values of 23 µM, 48 µM and 231 µM for *Verona integron-encoded metallo-β-lactamase* (VIM-2)*, German imipenemase-1 (GIM-1)* and New Delhi metallo-β-lactamase (NDM-1), respectively ^[1].

HY-P1195

PDZ1 Domain inhibitor peptide	iGluR	Neurological Disease
PDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain ^[1].

HY-P1195A

PDZ1 Domain inhibitor peptide TFA	iGluR	Neurological Disease
PDZ1 Domain inhibitor peptide TFA, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide TFA disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain ^[1].

HY-P10857

Microcin J25 MccJ25	Bacterial Antibiotic	Infection
Microcin J25 (MccJ25) is a cyclic peptide antibiotic consisting of 21 unmodified amino acid residues. Microcin J25 inhibits DNA-dependent RNA polymerase (RNAP) of Gram-negative bacteria. Microcin J25 has antibacterial activity ^[1] .

HY-P2064

Lariatin A	Bacterial	Infection
Lariatins is a novel anti-mycobacterial peptides with a lasso structure produced by Rhodococcus jostii K01-B0171 ^[1].

HY-P0007

Elcatonin CarbocalcitonIN	Drug Intermediate	Metabolic Disease
Elcatonin (Carbocalcitonin) is a synthetic analog of eel calcitonin. Elcatonin increases bone mineral density, inhibits bone resorption and processes a central analgesic effect ^[1].

HY-P10768

Ro 25-1553	PACAP Receptor	Neurological Disease
Ro 25-1553 is a 31 amino acid vasoactive intestinal peptide (VIP) analog, that acts as an agonist for VIP2 receptor (VPAC2 receptor). Ro 25-1553 exhibits a bronchodilator effect in nerve-induced or Carbachol (HY-B1208)-induced tracheal smooth muscle contraction in guinea pig model ^[1].

HY-P0267

Melanotan (MT)-II 1 Publications Verification	Melanocortin Receptor	Neurological Disease
Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an injectable peptide hormone used to promote tanning.

HY-P3100

Orfamide A	Parasite	Infection
Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC₅₀ value of 34.5 μg/mL ^[1].

HY-106178

PMX-53 4 Publications Verification 3D53	Complement System	Cardiovascular Disease Inflammation/Immunology Cancer
PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC₅₀ of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to *C5aR1* and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects ^[1] .

HY-P2123A

Colistin A sulfate hydrate	Bacterial Antibiotic	Infection
Colistin A sulfate hydrate is a major component of Colistin. Colistin is a polymyxin antibiotic and can be used to combat infections caused by problematic gram-negative bacteria ^[1].

HY-P1208A

PG-931 TFA	Melanocortin Receptor	Inflammation/Immunology
PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R(IC₅₀=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-P0227

SHU 9119 3 Publications Verification	Melanocortin Receptor	Metabolic Disease
SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC₅₀ values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.

HY-P1208

PG-931	Melanocortin Receptor	Inflammation/Immunology
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-P1209A

PG106 TFA	Melanocortin Receptor	Metabolic Disease
PG106 TFA is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC₅₀= 210 nM) and has noactivity at hMC4 receptors (EC₅₀=9900 nM) and hMC5 receptor ^[1].

HY-P1209

PG106	Melanocortin Receptor	Inflammation/Immunology
PG106 is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC₅₀=210 nM) and has noactivity at hMC4 receptors (EC₅₀=9900 nM) and hMC5 receptor ^[1].

HY-P5568

RP 71955	HIV	Infection
RP 71955 is an antimicrobial peptide against HIV-1 ^[1].

HY-P2202

Desferriferribactin	Bacterial	Others
Desferriferribactin is a cyclic peptide containing a thirteen-membered ring. Desferriferribactin is a precursor of pyoverdins ^[1].

HY-P2120

Pseudobactin A	Bacterial	Others
Pseudobactin A is a non-fluorescent extracellular iron carrier produced by the plant growth-promoting bacterium Pseudomonas B10 ^[1].

HY-P10447

Plipastatin A1 FengycIN IX; SNA-60-367-3	Phospholipase	Inflammation/Immunology
Plipastatin A1 is a lipopeptide with enzyme inhibitory and immunosuppressive activities. Plipastatin A1 is found in Bacillus cereus and inhibits phospholipase A2 (PLA2), PLC, and PLD ^[1].

HY-P1108

Astressin 2B	CFTR	Others
Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and *CRF1, respectively. Astressin 2B antagonizes CRF2*-mediated inhibition of gastric emptying ^[1] .

HY-P1108A

Astressin 2B TFA	CFTR	Others
Astressin 2B TFA is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and *CRF1, respectively. Astressin 2B TFA antagonizes CRF2*-mediated inhibition of gastric emptying ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P1195

PDZ1 Domain inhibitor peptide	iGluR	Neurological Disease
PDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain ^[1].

HY-P0267

Melanotan (MT)-II 1 Publications Verification	Melanocortin Receptor	Neurological Disease
Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an injectable peptide hormone used to promote tanning.

HY-106178

PMX-53 4 Publications Verification 3D53	Complement System	Cardiovascular Disease Inflammation/Immunology Cancer
PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC₅₀ of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to *C5aR1* and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects ^[1] .

HY-P1195A

PDZ1 Domain inhibitor peptide TFA	iGluR	Neurological Disease
PDZ1 Domain inhibitor peptide TFA, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide TFA disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain ^[1].

HY-P10278

Anantin	Peptides	Endocrinology
Anantin binds competitively to the receptor of atrial natriuretic factor (ANF) from bovine adrenal cortex (K_d = 0.6 μM) and acts as natriuretic peptide receptor A antagonist ^[1] .

HY-P10857

Microcin J25 MccJ25	Bacterial Antibiotic	Infection
Microcin J25 (MccJ25) is a cyclic peptide antibiotic consisting of 21 unmodified amino acid residues. Microcin J25 inhibits DNA-dependent RNA polymerase (RNAP) of Gram-negative bacteria. Microcin J25 has antibacterial activity ^[1] .

HY-P2064

Lariatin A	Bacterial	Infection
Lariatins is a novel anti-mycobacterial peptides with a lasso structure produced by Rhodococcus jostii K01-B0171 ^[1].

HY-P0007

Elcatonin CarbocalcitonIN	Drug Intermediate	Metabolic Disease
Elcatonin (Carbocalcitonin) is a synthetic analog of eel calcitonin. Elcatonin increases bone mineral density, inhibits bone resorption and processes a central analgesic effect ^[1].

HY-P10768

Ro 25-1553	PACAP Receptor	Neurological Disease
Ro 25-1553 is a 31 amino acid vasoactive intestinal peptide (VIP) analog, that acts as an agonist for VIP2 receptor (VPAC2 receptor). Ro 25-1553 exhibits a bronchodilator effect in nerve-induced or Carbachol (HY-B1208)-induced tracheal smooth muscle contraction in guinea pig model ^[1].

HY-P3100

Orfamide A	Parasite	Infection
Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC₅₀ value of 34.5 μg/mL ^[1].

HY-P2123A

Colistin A sulfate hydrate	Bacterial Antibiotic	Infection
Colistin A sulfate hydrate is a major component of Colistin. Colistin is a polymyxin antibiotic and can be used to combat infections caused by problematic gram-negative bacteria ^[1].

HY-P1208A

PG-931 TFA	Melanocortin Receptor	Inflammation/Immunology
PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R(IC₅₀=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-P1193

GR 82334	Peptides	Neurological Disease
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist ^[1]. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats ^[1].

HY-P0227

SHU 9119 3 Publications Verification	Melanocortin Receptor	Metabolic Disease
SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC₅₀ values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.

HY-P1208

PG-931	Melanocortin Receptor	Inflammation/Immunology
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-P1209A

PG106 TFA	Melanocortin Receptor	Metabolic Disease
PG106 TFA is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC₅₀= 210 nM) and has noactivity at hMC4 receptors (EC₅₀=9900 nM) and hMC5 receptor ^[1].

HY-P1209

PG106	Melanocortin Receptor	Inflammation/Immunology
PG106 is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC₅₀=210 nM) and has noactivity at hMC4 receptors (EC₅₀=9900 nM) and hMC5 receptor ^[1].

HY-P5568

RP 71955	HIV	Infection
RP 71955 is an antimicrobial peptide against HIV-1 ^[1].

HY-P2202

Desferriferribactin	Bacterial	Others
Desferriferribactin is a cyclic peptide containing a thirteen-membered ring. Desferriferribactin is a precursor of pyoverdins ^[1].

HY-P2120

Pseudobactin A	Bacterial	Others
Pseudobactin A is a non-fluorescent extracellular iron carrier produced by the plant growth-promoting bacterium Pseudomonas B10 ^[1].

HY-P10447

Plipastatin A1 FengycIN IX; SNA-60-367-3	Phospholipase	Inflammation/Immunology
Plipastatin A1 is a lipopeptide with enzyme inhibitory and immunosuppressive activities. Plipastatin A1 is found in Bacillus cereus and inhibits phospholipase A2 (PLA2), PLC, and PLD ^[1].

HY-P1108

Astressin 2B	CFTR	Others
Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and *CRF1, respectively. Astressin 2B antagonizes CRF2*-mediated inhibition of gastric emptying ^[1] .

HY-P1108A

Astressin 2B TFA	CFTR	Others
Astressin 2B TFA is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and *CRF1, respectively. Astressin 2B TFA antagonizes CRF2*-mediated inhibition of gastric emptying ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1434

7-Aminocephalosporanic acid 1 Publications Verification 7-ACA	Infection Classification of Application Fields Disease Research Fields	Beta-lactamase Bacterial Antibiotic
7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor ^[1] .

Cat. No.	Product Name	Chemical Structure

HY-14879S2

Avibactam sodium salt-13C5
Avibactam sodium salt- ¹³C₅ (NXL-104- ¹³C₅) is ¹³C labeled Avibactam (sodium). Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase *TEM-1* and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively ^[1] .

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β-Lactamase-IN-1

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products