2. Anti-infection
  3. Beta-lactamase Bacterial Antibiotic
  4. Avibactam sodium hydrate

Avibactam sodium hydrate  (Synonyms: NXL-104 hydrate)

Cat. No.: HY-14879B Purity: 99.95%
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Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively.

For research use only. We do not sell to patients.

Avibactam sodium hydrate Chemical Structure

Avibactam sodium hydrate Chemical Structure

CAS No. : 2938989-90-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 79 In-stock
Solution
10 mM * 1 mL in Water USD 79 In-stock
Solid
5 mg USD 72 In-stock
10 mg USD 96 In-stock
50 mg USD 156 In-stock
100 mg USD 228 In-stock
200 mg USD 312 In-stock
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Based on 67 publication(s) in Google Scholar

Other Forms of Avibactam sodium hydrate:

Avibactam sodium hydrate Related Antibodies

Top Publications Citing Use of Products

66 Publications Citing Use of MCE Avibactam sodium hydrate

Proliferation Assay

    Avibactam sodium hydrate purchased from MedChemExpress. Usage Cited in: J Antimicrob Chemother. 2017 Jul 1;72(7):1930-1936.  [Abstract]

    Total β-lactamase activity for bacterial lysates is measured using the chromogenic substrate nitrocefin, with or without Avibactam at 4 mg/L. (b) GR20263 hydrolysis activity of different bacterial lysates is determined with or without Avibactam at 4 mg/L.

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    • Biological Activity

    • Purity & Documentation

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    Description

    Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].

    IC50 & Target

    IC50: 5 nM (CTX-M-15), 8 nM (TEM-1)[1]
    In Vitro

    Avibactam is a molecule with little antibacterial activity, that inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases[2].
    Ceftazidime (HY-B0593)-Avibactam (0-256 mg/L) inhibits 16 blaKPC-2 positive and 1 of blaOXA-232 positive Klebsiella pneumonia growth with MIC50 and MIC90 for both 8 mg/L[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Avibactam sodium hydrate Related Antibodies
    In Vivo

    Ceftazidime-Avibactam (0.375 mg/g; s.c.; q8h for 10 days) has a significant effect on the bacteria and led to a certain therapeutic efficacy in K. pneumoniae strain Y8 infected mouse model[3].
    Avibactam (64 mg/kg; s.c.; once) shows mean estimated half-life in plasma in the terminal phase of 0.24 h in Pseudomonas aeruginosa infected neutropenic mice with lung infection[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Six-week-old BALB/c mice (female), K. pneumoniae strain Y8 infection model[4]
    Dosage: 0.375 mg/g in combination with Ceftazidime
    Administration: Subcutaneous injection, 4 h post infection and given every 8 h for 10 days
    Result: 70% of infection group mice died within 4 days, and all mice in the PBS group died within 13 days. All treatment group mice survived at 10 days post infection with the antibiotic applied every 8 h, whereas 100% of mice in this group died within 4 days after the antibiotic treatment stopped. The spleen and liver of treatment group mice showed lower CFU counts, as compare with that of infected group.
    Clinical Trial
    Molecular Weight

    305.24

    Formula

    C7H12N3NaO7S
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=S(ON1[C@]2([H])CC[C@@H](C(N)=O)[N@@](C2)C1=O)(O[Na])=O.O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 200 mg/mL (655.22 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2761 mL 16.3806 mL 32.7611 mL
    5 mM 0.6552 mL 3.2761 mL 6.5522 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 25 mg/mL (81.90 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.2761 mL 16.3806 mL 32.7611 mL 81.9028 mL
    5 mM 0.6552 mL 3.2761 mL 6.5522 mL 16.3806 mL
    10 mM 0.3276 mL 1.6381 mL 3.2761 mL 8.1903 mL
    15 mM 0.2184 mL 1.0920 mL 2.1841 mL 5.4602 mL
    20 mM 0.1638 mL 0.8190 mL 1.6381 mL 4.0951 mL
    25 mM 0.1310 mL 0.6552 mL 1.3104 mL 3.2761 mL
    30 mM 0.1092 mL 0.5460 mL 1.0920 mL 2.7301 mL
    40 mM 0.0819 mL 0.4095 mL 0.8190 mL 2.0476 mL
    50 mM 0.0655 mL 0.3276 mL 0.6552 mL 1.6381 mL
    60 mM 0.0546 mL 0.2730 mL 0.5460 mL 1.3650 mL
    80 mM 0.0410 mL 0.2048 mL 0.4095 mL 1.0238 mL
    100 mM 0.0328 mL 0.1638 mL 0.3276 mL 0.8190 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Avibactam sodium hydrate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Avibactam sodium2938989-90-1NXL-104NXL104NXL 104Beta-lactamaseBacterialAntibioticβ-lactamaseTEM-1CTX-M-15antibacterialKlebsiella pneumoniaPseudomonas aeruginosaInhibitorinhibitorinhibit

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