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11(Z),14(Z),17(Z)-Eicosatrienoic acid methyl ester

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-158938
    11(Z),14(Z),17(Z)-Eicosatrienoic acid methyl ester

    		Endogenous Metabolite Others
    11(Z),14(Z),17(Z)-Eicosatrienoic acid methyl ester is found in Nannochloropsis. 11(Z),14(Z),17(Z)-Eicosatrienoic acid methyl ester can also be extracted from diesel-contaminated soil .
    11(Z),14(Z),17(Z)-Eicosatrienoic acid methyl ester
  • HY-W747562
    Leukotriene A 3 methyl ester

    		Lipoxygenase Others
    Leukotriene A 3 methyl ester occurs from 5,8,11-eicosatrienoic acid via the 5-LO pathway.
    Leukotriene A 3 methyl ester
  • HY-165061
    5(Z),11(Z),14(Z)-Eicosatrienoic acid

    Sciadonic acid

    		 Apolipoprotein Inflammation/Immunology
    5(Z),11(Z),14(Z)-Eicosatrienoic acid (Sciadonic acid), a polyunsaturated fatty acid sourced from maritime pine seed oil, gymnospermae leaves and seeds, and freshwater gastropods, has been shown to reduce high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1 when included in their diet. In vitro studies indicate that it diminishes cholesterol efflux, and when applied topically in its methyl ester form, it alleviates inflammatory processes, likely by displacing arachidonic acid from phospholipid pools and lowering concentrations of downstream inflammatory mediators such as prostaglandin E2 and leukotrienes.
    5(Z),11(Z),14(Z)-Eicosatrienoic acid
  • HY-141635
    cis-11,14-Eicosadienoic acid methyl ester

    		Endogenous Metabolite Metabolic Disease
    cis-11,14-Eicosadienoic acid methyl ester is a more lipid soluble form of the ω-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid, a naturally occurring PUFA. 11(Z),14(Z)-Eicosadienoic acid competitively inhibits inosine 5’-monophosphate dehydrogenase (Ki=3.1 μM) and inhibits the binding of LTB4 to its receptor on neutrophils (Ki=3.0 μM). Also, serum levels of eicosadienoic acids negatively correlate with degree of sleep disturbance.3 Eicosadienoic acids are converted by desaturases, in vivo, to eicosatrienoic acids, which are potent vasodilators.
    cis-11,14-Eicosadienoic acid methyl ester

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