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Isoforms Recommended:	5-HT₃ Receptor

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5HT3-receptor

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By Targets:	5-HT Receptor (85) Adrenergic Receptor (1) Apoptosis (2) Dopamine Receptor (1) Drug Metabolite (1) Endogenous Metabolite (3) Histamine Receptor (1) Isotope-Labeled Compounds (5) mAChR (1) Monoamine Oxidase (1) nAChR (10)
By Research Areas:	Cancer (19) Cardiovascular Disease (3) Endocrinology (1) Inflammation/Immunology (6) Metabolic Disease (4) Neurological Disease (84)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-70050CS

Alosetron D3 Hydrochloride GR-68755C d₃	5-HT Receptor	Neurological Disease
Alosetron-d₃ (hydrochloride) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist.

HY-70050AS

Alosetron-d3 GR 68755-d₃; GR 68755X-d₃	Isotope-Labeled Compounds 5-HT Receptor	Neurological Disease
Alosetron-d₃ is a deuterium labeled Alosetron. Alosetron is a serotonin 5HT3-receptor antagonist[1].

HY-106909A

YM114 KAE-393	5-HT Receptor	Cardiovascular Disease
YM114 (KAE-393) is a highly potent and selective *(5-HT)₃-receptor* antagonist that does not affect Veratridine (HY-N6691)- or electrical stimulation-induced bradycardia in anesthetized rats. YM114 inhibits 2-methyl-5-HT (HY-19358)-induced Bezold-Jarisch reflex, which originates from *(5-HT)₃-receptor* located on the endings of vagal afferent nerves in the heart .

HY-U00234

Zatosetron maleate LY 277359 maleate	5-HT Receptor	Neurological Disease
Zatosetron maleate is a potent and selective *5HT3 receptor* antagonist.

HY-106807

Litoxetine SL 81.0385	5-HT Receptor	Neurological Disease
Litoxetine (SL 81.0385) is a selective 5-HT uptake inhibitor. Litoxetine is a 5-HT₃ receptor antagonist with a K_i of 85 nM for cerebral 5-HT₃ receptors. Litoxetine is an antidepressant and has antiemetic properties .

HY-19684

Pancopride LAS 30451	5-HT Receptor	Neurological Disease
Pancopride is a new potent and selective *5-HT₃ receptor* antagonist.

HY-109543A

Indisetron dihydrochloride	5-HT Receptor	Neurological Disease
Indisetron dihydrochloride is a *5-HT3 receptor* antagonist with anti-emetic activity.

HY-109543

Indisetron	5-HT Receptor
Indisetron is a *5-HT3 receptor* antagonist with anti-emetic activity.

HY-U00322

5-HT3 antagonist 3	5-HT Receptor	Neurological Disease
5-HT3 antagonist 3 (Compound 15b) is a high-affinity *5-HT3 receptor* antagonist. 5-HT3 antagonist 3 binds to 5-HT3 receptors in rat brain cortical membranes with K_i of 0.25 nM .

HY-U00408

5-HT3 antagonist 2	5-HT Receptor	Neurological Disease
5-HT3 antagonist 2 is a *5-HT3* receptor antagonist.

HY-111156

NW-1172 free base	Monoamine Oxidase	Neurological Disease
NW-1172 (free base) (compound 22b) is a 5-HT3 receptor antagonist with performance-enhancing activity in a delayed matching task in monkeys, with the (R) isomer producing more systematic improvements than the (S) isomer, a difference paralleled by the higher affinity of the (R) enantiomer for the 5-HT3 receptor.

HY-101331

Phenylbiguanide N-Phenylbiguanide; PBG; 1-Phenylbiguanide	5-HT Receptor	Neurological Disease
Phenylbiguanide is a *5-HT₃ receptor* selective agonist with an EC₅₀ of 3.0±0.1 μM.

HY-101062

3-AQC	5-HT Receptor	Neurological Disease
3-AQC, a piperazinylquinoxaline derivative, is a potent and competitive *5-HT₃* receptor antagonist .

HY-105109

Cilansetron	5-HT Receptor	Neurological Disease
Cilansetron is a *5-HT3* receptor antagonist. Cilansetron can be used in studies of irritable bowel syndrome .

HY-105196

DAT-582	5-HT Receptor	Neurological Disease
DAT-582 is a serotonin 3 (5-HT3) receptor antagonist that has an antiemetic effect .

HY-105108

Cilansetron hydrochloride hydrate	5-HT Receptor	Neurological Disease
Cilansetron hydrochloride hydrate is a *5-HT3* receptor antagonist. Cilansetron hydrochloride hydrate can be used in studies of irritable bowel syndrome .

HY-116554

GYKI-46903	5-HT Receptor	Neurological Disease
GYKI-46903 is a non-competitive antagonist for *5-HT3 receptor, with the pIC₅₀* of 6.91 .

HY-B0071

Granisetron BRL 43694	5-HT Receptor	Neurological Disease
Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

HY-B0071A

Granisetron Hydrochloride BRL 43694A	5-HT Receptor	Neurological Disease Cancer
Granisetron (Hydrochloride) (BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

HY-B0750

Dolasetron MDL-73147	5-HT Receptor	Others
Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.

HY-U00368

5-HT3 antagonist 1	5-HT Receptor	Neurological Disease
5-HT3 antagonist 1 is a potent and selective antagonist of serotonin 3 (5-HT3) receptor.

HY-B1541

Bemesetron MDL 72222	5-HT Receptor	Neurological Disease
Bemesetron (MDL 72222) is a selective *5-HT₃ receptor* antagonist with an IC₅₀ of 0.33 nM . Neuroprotective effect .

HY-44132A

Dehydro Palonosetron hydrochloride RS 42358-197 hydrochloride	5-HT Receptor	Cancer
Dehydro Palonosetron hydrochloride (RS 42358-197 hydrochloride) is a *5-HT3 receptor* antagonist. Dehydro Palonosetron hydrochloride has an antiemetic effect .

HY-102064

SR 57227A 1 Publications Verification	5-HT Receptor	Neurological Disease
SR 57227A is a potent, orally active and selective *5-HT3 receptor* agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC₅₀) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects .

HY-B0750A

Dolasetron Mesylate MDL-73147EF	5-HT Receptor	Cancer
Dolasetron Mesylate (MDL-73147EF) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.

HY-B0750B

Dolasetron Mesylate hydrate MDL-73147EF hydrate	5-HT Receptor	Others
Dolasetron Mesylate hydrate (MDL-73147EF hydrate) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.

HY-101050

Tropanserin MDL 72422	5-HT Receptor	Cardiovascular Disease
Tropanserin is a serotoninergic active compound, as well as a 5HT3 receptor antagonist. Tropanserin modulates Cardio-respiratory reflex effects of an exogenous serotonin challenge .

HY-B0595

Ramosetron Hydrochloride YM060	5-HT Receptor	Neurological Disease Inflammation/Immunology Cancer
Ramosetron (YM060) Hydrochloride is an orally active 5-HT3 receptor antagonist used for studying nausea, vomiting, and inflammatory diseases .

HY-105109B

(S)-Cilansetron	Others	Neurological Disease
(S)-Cilansetron is the S-isomer of Cilansetron. Cilansetron is a *5-HT3* receptor antagonist that can be used in research related to irritable bowel syndrome .

HY-B0002

Ondansetron hydrochloride 5+ Cited Publications GR 38032 hydrochloride; SN 307 hydrochloride	5-HT Receptor	Neurological Disease
Ondansetron hydrochloride (GR 38032 hydrochloride; SN 307 hydrochloride) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.

HY-19199

E-3620	5-HT Receptor	Neurological Disease Metabolic Disease
E-3620 is a potent *5-HT₃* receptor antagonist. E-3620 can be used for the research of dyskinesi and gastrointestinal motility .

HY-B0068

Azasetron hydrochloride 2 Publications Verification Y-25130 hydrochloride	5-HT Receptor	Neurological Disease
Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective *5-HT3* receptor antagonist. Azasetron is used in the study for Chemotherapy-induced nausea and vomiting (CINV) .

HY-B0020

Tropisetron Hydrochloride 3 Publications Verification SDZ-ICS-930	5-HT Receptor nAChR	Neurological Disease Inflammation/Immunology Cancer
Tropisetron Hydrochloride (SDZ-ICS-930) is an effective neuroprotective agent that acts as a *5-HT3* receptor antagonist, a calmodulin inhibitor, and an α7-nAChRreceptor agonist, with an IC₅₀ of 70.1 nM for the 5-HT3 receptor. Tropisetron Hydrochloride has anti-inflammatory properties and immune-regulating functions, effectively alleviating symptoms associated with chemotherapy and post-surgery. Tropisetron Hydrochloride reduces Ab (HY-P4867)-induced hippocampal neuroinflammation .

HY-119806

TMPPAA	5-HT Receptor	Neurological Disease
TMPPAA is an allosteric agonist and positive allosteric modulator of the *5-HT3* receptor. TMPPAA enhances 5-HT-mediated 5-HT3AR signaling .

HY-B0020R

Tropisetron (Hydrochloride) (Standard) SDZ-ICS-9323 (Standard)	5-HT Receptor nAChR	Neurological Disease Cancer
Tropisetron (Hydrochloride) (Standard) is the analytical standard of Tropisetron (Hydrochloride). Tropisetron Hydrochloride (SDZ-ICS-930) is an effective neuroprotective agent that acts as a *5-HT3* receptor antagonist, a calmodulin inhibitor, and an α7-nAChRreceptor agonist, with an IC₅₀ of 70.1 nM for the 5-HT3 receptor. Tropisetron Hydrochloride has anti-inflammatory properties and immune-regulating functions, effectively alleviating symptoms associated with chemotherapy and post-surgery. Tropisetron Hydrochloride reduces Ab (HY-P4867)-induced hippocampal neuroinflammation .

HY-B0071R

Granisetron (Standard)	5-HT Receptor	Neurological Disease Cancer
Granisetron (Standard) is the analytical standard of Granisetron. This product is intended for research and analytical applications. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

HY-A0008

Talipexole dihydrochloride B-HT 920 dihydrochloride	Adrenergic Receptor Dopamine Receptor 5-HT Receptor	Neurological Disease Endocrinology
Talipexole dihydrochloride (B-HT 920 dihydrochloride) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.

HY-B0072

Tropisetron 3 Publications Verification SDZ-ICS-930 free base	5-HT Receptor nAChR	Neurological Disease Cancer
Tropisetron (SDZ-ICS-930 free base) is a selective *5-HT3 receptor* antagonist (IC₅₀: 70.1 nM) and *α7-nicotinic receptor* agonist** .

HY-132348S

Granisetron-d3	Isotope-Labeled Compounds 5-HT Receptor	Neurological Disease
Granisetron-d₃ is the deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy[1][2].

HY-B0071AR

Granisetron Hydrochloride (Standard) BRL 43694A (Standard)	5-HT Receptor	Neurological Disease Cancer
Granisetron (Hydrochloride) (Standard) is the analytical standard of Granisetron (Hydrochloride). This product is intended for research and analytical applications. Granisetron (Hydrochloride) (BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

HY-B0750S1

Dolasetron-d5 MDL-73147-d₅	5-HT Receptor Isotope-Labeled Compounds	Cancer
Dolasetron-d₅ is deuterated labeled Dolasetron (HY-B0750). Dolasetron (MDL-73147) is a *5-HT3* receptor antagonist with potential for treatment of chemotherapy-induced nausea and vomiting.

HY-B0002BS

Ondansetron-d5 GR 38032-d₅; SN 307-d₅	5-HT Receptor	Neurological Disease
Ondansetron-d₅ is the deuterium labeled Ondansetron. Ondansetron (GR 38032; SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.

HY-100552

VUF10166	5-HT Receptor	Neurological Disease
VUF10166 is a potent and high-affinity *5-HT₃ receptor* antagonist, with K_i values of 0.04 nM (5-HT₃A) and 22 nM (5-HT₃AB). VUF10166 inhibits 5-HT-induced responses at 5-HT₃A and 5-HT₃AB receptors at nanomolar concentrations. At *5-HT₃ receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC₅₀* of 5.2 μM .

HY-B0002S

Ondansetron-d3 hydrochloride	Isotope-Labeled Compounds 5-HT Receptor	Neurological Disease
Ondansetron-d₃ (hydrochloride) is the deuterium labeled Ondansetron hydrochloride. Ondansetron hydrochloride (GR 38032 hydrochloride) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[1][2].

HY-44132AR

Dehydro Palonosetron hydrochloride (Standard)	5-HT Receptor	Cancer
Dehydro Palonosetron (hydrochloride) (Standard) is the analytical standard of Dehydro Palonosetron (hydrochloride). This product is intended for research and analytical applications. Dehydro Palonosetron hydrochloride (RS 42358-197 hydrochloride) is a 5-HT3 receptor antagonist. Dehydro Palonosetron hydrochloride has an antiemetic effect .

HY-14442

ML 10302 hydrochloride	5-HT Receptor	Neurological Disease Metabolic Disease
ML 10302 hydrochloride is a potent and selective 5-HT₄ receptor agonist, with an EC₅₀ of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over *5-HT₃* receptor in binding assay .

HY-131954

5-HT3 antagonist 4	5-HT Receptor	Neurological Disease
5-HT3 antagonist 4 is a 5-HT3 receptor (5HT3R) antagonist. 5-HT3 antagonist 4 prevents diabetes-induced depressive phenotypes in mice .

HY-B0352B

(R)-Mirtazapine (R)-Org3770; (R)-6-Azamianserin	5-HT Receptor	Neurological Disease
(R)-Mirtazapine ((R)-Org3770) is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a *5-HT₃ receptor* antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4 .

HY-19692

Itasetron DA 6215; U98079A	5-HT Receptor	Neurological Disease
Itasetron (DA 6215) is a selective *5-HT₃* receptor antagonist. Itasetron improves spatial learning and memory abilities in the aged rat. Itasetron has potent antiemetic properties. Itasetron is used for age-related memory degeneration in rodents .

HY-105201A

Fabesetron hydrochloride FK1052	5-HT Receptor	Neurological Disease Cancer
Fabesetron (FK1052) hydrochloride is an orally active *5-HT₃ receptor* antagonist with 5-HT₄ receptor antagonistic activity. Fabesetron hydrochloride can be used in the study for both acute and delayed emesis induced by cancer chemotherapy .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W015169

5-Methoxytryptamine O-Methylserotonin	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Indole Alkaloids Cancer	Drug Metabolite 5-HT Receptor Endogenous Metabolite
5-Methoxytryptamine, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine is also a potent antioxidant and has radioprotective action .

HY-W015169A

5-Methoxytryptamine hydrochloride	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Indole Alkaloids Cancer	5-HT Receptor Endogenous Metabolite
5-Methoxytryptamine hydrochloride, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine hydrochloride has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine hydrochloride is also a potent antioxidant and has radioprotective action .

HY-W001160

5-Hydroxyindole	Alkaloids Structural Classification Monophenols Classification of Application Fields Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields Indole Alkaloids	Endogenous Metabolite
5-Hydroxyindole, a hydroxylated indole, can be found in a vast array of pharmacologically active agents and natural products. 5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells .

HY-B2065

Scopolamine hydrochloride (-)-Scopolamine hydrochloride; Hyoscine hydrochloride	Alkaloids Structural Classification Other Alkaloids Source classification Atropa belladonna Linn. Solanaceae Plants	mAChR 5-HT Receptor
Scopolamine hydrochloride is a non-selective and high affinity (≤1 nM) muscarinic antagonist that is used for the prevention of post-operative nausea and vomiting. Scopolamine readily passes the blood brain barrier. Scopolamine also reversibly inhibits *5-HT3* receptor-responses with an IC₅₀ of 2.09 μM . Scopolamine induces Alzheimer's disease-like pathology through alteration of cholinergic system .

Cat. No.	Product Name	Chemical Structure

HY-70050CS

Alosetron D3 Hydrochloride
Alosetron-d₃ (hydrochloride) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist.

HY-B0002BS

Ondansetron-d5
Ondansetron-d₅ is the deuterium labeled Ondansetron. Ondansetron (GR 38032; SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.

HY-B0002S

Ondansetron-d3 hydrochloride
Ondansetron-d₃ (hydrochloride) is the deuterium labeled Ondansetron hydrochloride. Ondansetron hydrochloride (GR 38032 hydrochloride) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[1][2].

HY-B0352S

Mirtazapine D3
Mirtazapine-d₃ is a deuterium labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors[1].

HY-70050AS

Alosetron-d3
Alosetron-d₃ is a deuterium labeled Alosetron. Alosetron is a serotonin 5HT3-receptor antagonist[1].

HY-132348S

Granisetron-d3
Granisetron-d₃ is the deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy[1][2].

HY-B0750S1

Dolasetron-d5
Dolasetron-d₅ is deuterated labeled Dolasetron (HY-B0750). Dolasetron (MDL-73147) is a *5-HT3* receptor antagonist with potential for treatment of chemotherapy-induced nausea and vomiting.

HY-B0002BS1

Ondansetron-d3
Ondansetron-d₃ is the deuterium labeled Ondansetron[1]. Ondansetron(GR 38032;SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[2].

HY-B0002S1

Ondansetron-d6 hydrochloride
Ondansetron-d₆ (hydrochloride) is the deuterium labeled Ondansetron hydrochloride[1]. Ondansetron hydrochloride is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[2][3][4][5][6][7].

HY-B0352BS

(R)-Mirtazapine-d3
(R)-Mirtazapine-d₃ is a deuterium labeled (R)-Mirtazapine. (R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a 5-HT3 receptor antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4[1].

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5HT3-receptor

Inhibitors & Agonists

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Isotope-Labeled Compounds

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