2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. RS-64459-193

RS-64459-193 is a 5-HT1A receptor partial agonist with a Ki of 24.9 nM. RS-64459-193 also shows high affinity for 5-HT2C, 5-HT2A and 5-HT7 with pKi values of 6.87, 7.02, and 7.18, respectively. RS-64459-193 is almost devoid of activity at the m 5-HT3 receptor.

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RS-64459-193 Chemical Structure

RS-64459-193 Chemical Structure

CAS No. : 123882-89-3

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RS-64459-193 Related Antibodies

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Description

RS-64459-193 is a 5-HT1A receptor partial agonist with a Ki of 24.9 nM. RS-64459-193 also shows high affinity for 5-HT2C, 5-HT2A and 5-HT7 with pKi values of 6.87, 7.02, and 7.18, respectively. RS-64459-193 is almost devoid of activity at the m 5-HT3 receptor[1].

IC50 & Target[1]

5-HT1A Receptor

24.9 nM (Ki, CHO cells)

human 5-HT1A Receptor

7.6 (pKi, Sf9)

human 5-HT1A Receptor

7.04 (pKi)

5-HT2C Receptor

6.87 (pKi)

Rat 5-HT2A

7.02 (pKi)

Human 5-HT7 Receptor

7.18 (pKi)

5-HT3 Receptor

<4 (pKi)

Molecular Weight

479.48

Formula

C26H36Cl2N2O2
CAS No.
SMILES

O=C1N(C(CC2(CCCC2)C1)=O)CCCCN3CC4C5=C(CCC4)C=CC(Cl)=C5CC3.[H]Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RS-64459-193 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RS-64459-193123882-89-35-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT1A AgonistInhibitorinhibitorinhibit

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