2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. YM114

YM114 (KAE-393) is a highly potent and selective (5-HT)3-receptor antagonist that does not affect Veratridine (HY-N6691)- or electrical stimulation-induced bradycardia in anesthetized rats. YM114 inhibits 2-methyl-5-HT (HY-19358)-induced Bezold-Jarisch reflex, which originates from (5-HT)3-receptor located on the endings of vagal afferent nerves in the heart.

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YM114 Chemical Structure

YM114 Chemical Structure

CAS No. : 153608-99-2

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YM114 Related Antibodies

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Description

YM114 (KAE-393) is a highly potent and selective (5-HT)3-receptor antagonist that does not affect Veratridine (HY-N6691)- or electrical stimulation-induced bradycardia in anesthetized rats. YM114 inhibits 2-methyl-5-HT (HY-19358)-induced Bezold-Jarisch reflex, which originates from (5-HT)3-receptor located on the endings of vagal afferent nerves in the heart[1].

Molecular Weight

303.79

Formula

C16H18ClN3O
CAS No.
SMILES

O=C([C@H]1CC2=C(N=CN2)CC1)N3C4=CC=CC=C4CC3.Cl
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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YM114 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YM114153608-99-2KAE-393YM 114YM-114KAE393KAE 3935-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor(5-HT)3-receptorBezold-Jarisch reflexratsInhibitorinhibitorinhibit

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