1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. YM114

YM114 is a highly potent and selective (5-HT)3-receptor antagonist that does not affect Veratridine (HY-N6691)- or electrical stimulation-induced bradycardia in anesthetized rats. YM114 inhibits 2-methyl-5-HT (HY-19358)-induced Bezold-Jarisch reflex, which originates from (5-HT)3-receptor located on the endings of vagal afferent nerves in the heart.

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YM114 Chemical Structure

YM114 Chemical Structure

CAS No. : 153608-99-2

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Description

YM114 is a highly potent and selective (5-HT)3-receptor antagonist that does not affect Veratridine (HY-N6691)- or electrical stimulation-induced bradycardia in anesthetized rats. YM114 inhibits 2-methyl-5-HT (HY-19358)-induced Bezold-Jarisch reflex, which originates from (5-HT)3-receptor located on the endings of vagal afferent nerves in the heart[1].

Molecular Weight

303.79

Formula

C16H18ClN3O

CAS No.
SMILES

O=C([C@H]1CC2=C(N=CN2)CC1)N3C4=CC=CC=C4CC3.Cl

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
YM114
Cat. No.:
HY-106909A
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