2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Lurosetron

Lurosetron (GR-87442) is a 6-fluoro analogue of Alosetron (HY-70050A). Lurosetron is a serotonin 5-HT3 receptor antagonist. Lurosetron inhibits recombinant (rbt) CYP1A2, with an IC50 of 0.1 μM. Lurosetron also inhibits other CYP isoforms, including rbtCYP2C9 and rbtCYP3A4 with IC50s ranging between 3.5 μM and 16 μM..

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Lurosetron Chemical Structure

Lurosetron Chemical Structure

CAS No. : 128486-54-4

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Lurosetron Related Antibodies

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Description

Lurosetron (GR-87442) is a 6-fluoro analogue of Alosetron (HY-70050A). Lurosetron is a serotonin 5-HT3 receptor antagonist. Lurosetron inhibits recombinant (rbt) CYP1A2, with an IC50 of 0.1 μM. Lurosetron also inhibits other CYP isoforms, including rbtCYP2C9 and rbtCYP3A4 with IC50s ranging between 3.5 μM and 16 μM.[1].

IC50 & Target

5-HT3 Receptor

 

Molecular Weight

312.34

Formula

C17H17FN4O
CAS No.
SMILES

O=C1C2=C(CCN1CC3=C(NC=N3)C)N(C)C4=C2C=CC=C4F
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lurosetron Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lurosetron128486-54-4GR-87442GR87442GR 874425-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorhepatocytesmicrosomesmetabolismInhibitorinhibitorinhibit

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