2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Alosetron Hydrochloride

Alosetron Hydrochloride  (Synonyms: GR 68755C; GR 68755 Hydrochloride; GR 68755X Hydrochloride)

Cat. No.: HY-70050C Purity: 99.76%
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Alosetron Hydrochloride (GR 68755C) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.

For research use only. We do not sell to patients.

Alosetron Hydrochloride Chemical Structure

Alosetron Hydrochloride Chemical Structure

CAS No. : 122852-69-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 56 In-stock
Solution
10 mM * 1 mL in Water USD 56 In-stock
Solid
10 mg USD 40 In-stock
25 mg USD 88 In-stock
50 mg USD 141 In-stock
100 mg USD 227 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Alosetron Hydrochloride:

Alosetron Hydrochloride Related Antibodies

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  • Customer Review

Description

Alosetron Hydrochloride (GR 68755C) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects[1][2].

IC50 & Target

5-HT3 Receptor

 

In Vivo

Dexamethasone and Alosetron-treated (1 mg/kg; ip; daily for 6 days) rats exhibits a significant decrease in the diarrhea index, in comparison with TNBS-control group, especially after the initial 2 days of treatment following the induction of colitis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

330.81

Formula

C17H19ClN4O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(C1=C2C=CC=C1)=C(N2C)CC3)N3CC4=C(NC=N4)C.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (100.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0229 mL 15.1144 mL 30.2288 mL
5 mM 0.6046 mL 3.0229 mL 6.0458 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.0229 mL 15.1144 mL 30.2288 mL 75.5721 mL
5 mM 0.6046 mL 3.0229 mL 6.0458 mL 15.1144 mL
10 mM 0.3023 mL 1.5114 mL 3.0229 mL 7.5572 mL
15 mM 0.2015 mL 1.0076 mL 2.0153 mL 5.0381 mL
20 mM 0.1511 mL 0.7557 mL 1.5114 mL 3.7786 mL
25 mM 0.1209 mL 0.6046 mL 1.2092 mL 3.0229 mL
30 mM 0.1008 mL 0.5038 mL 1.0076 mL 2.5191 mL
40 mM 0.0756 mL 0.3779 mL 0.7557 mL 1.8893 mL
50 mM 0.0605 mL 0.3023 mL 0.6046 mL 1.5114 mL
60 mM 0.0504 mL 0.2519 mL 0.5038 mL 1.2595 mL
80 mM 0.0378 mL 0.1889 mL 0.3779 mL 0.9447 mL
100 mM 0.0302 mL 0.1511 mL 0.3023 mL 0.7557 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Alosetron Hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alosetron122852-69-1GR 68755CGR 68755GR 68755XGR68755GR-687555-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorselectivedepolarizationvisceralnociceptivecolitisInhibitorinhibitorinhibit

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