2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Ramosetron Hydrochloride

Ramosetron Hydrochloride  (Synonyms: YM060)

Cat. No.: HY-B0595 Purity: 99.95%
COA Handling Instructions

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Ramosetron (YM060) Hydrochloride is an orally active 5-HT3 receptor antagonist used for studying nausea, vomiting, and inflammatory diseases.

For research use only. We do not sell to patients.

Ramosetron Hydrochloride Chemical Structure

Ramosetron Hydrochloride Chemical Structure

CAS No. : 132907-72-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 In-stock
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Solid
50 mg USD 120 In-stock
100 mg USD 220 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Ramosetron Hydrochloride:

Ramosetron Hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All 5-HT Receptor Isoform Specific Products:

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ramosetron (YM060) Hydrochloride is an orally active 5-HT3 receptor antagonist used for studying nausea, vomiting, and inflammatory diseases[1][2][3].

IC50 & Target

5-HT3 Receptor

 

In Vitro

Ramosetron (1 μM) inhibits 5-HT3 receptor-dependent 5-HT release in guinea pig colonic mucosa[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ramosetron Hydrochloride Related Antibodies
In Vivo

Ramosetron (0.01-0.1 mg/kg, p.o., twice daily for 5 days) Ameliorates 5-fluorouracil (5-FU) (HY-90006)-induced intestinal mucositis in C57BL/6 mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-fluorouracil (5-FU) (HY-90006)-induced intestinal mucositis model in mice[2]
Dosage: 0.01-0.1 mg/kg
Administration: Oral gavage (p.o.), twice daily for 5 days
Result: Dose-dependently reduced the severity of intestinal mucositis, body weight loss, and diarrhea severity.
Clinical Trial
Molecular Weight

315.80

Formula

C17H18ClN3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(C)C2=C1C=CC=C2)[C@@H](C3)CCC4=C3NC=N4.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (316.66 mM; Need ultrasonic)

DMSO : 32 mg/mL (101.33 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1666 mL 15.8328 mL 31.6656 mL
5 mM 0.6333 mL 3.1666 mL 6.3331 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (79.16 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.96%

COA (253 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.1666 mL 15.8328 mL 31.6656 mL 79.1640 mL
5 mM 0.6333 mL 3.1666 mL 6.3331 mL 15.8328 mL
10 mM 0.3167 mL 1.5833 mL 3.1666 mL 7.9164 mL
15 mM 0.2111 mL 1.0555 mL 2.1110 mL 5.2776 mL
20 mM 0.1583 mL 0.7916 mL 1.5833 mL 3.9582 mL
25 mM 0.1267 mL 0.6333 mL 1.2666 mL 3.1666 mL
30 mM 0.1056 mL 0.5278 mL 1.0555 mL 2.6388 mL
40 mM 0.0792 mL 0.3958 mL 0.7916 mL 1.9791 mL
50 mM 0.0633 mL 0.3167 mL 0.6333 mL 1.5833 mL
60 mM 0.0528 mL 0.2639 mL 0.5278 mL 1.3194 mL
80 mM 0.0396 mL 0.1979 mL 0.3958 mL 0.9896 mL
100 mM 0.0317 mL 0.1583 mL 0.3167 mL 0.7916 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ramosetron Hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ramosetron132907-72-3YM060YM 060YM-0605-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorGuinea pig colonic mucosaIntestinal mucositis modelNauseaVomitingInflammatory diseasesInhibitorinhibitorinhibit

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