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AP-B

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W009724
    2-Aminoethyl diphenylborinate
    Maximum Cited Publications
    39 Publications Verification

    2-APB

    		 Calcium Channel TRP Channel CRAC Channel Inflammation/Immunology
    2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca 2+ (SOC) channel and activates some TRP channels (V1, V2 and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue .
    2-Aminoethyl diphenylborinate
  • HY-10435A
    SKF-82958 hydrobromide
    2 Publications Verification

    (±)-SKF-82958 hydrobromide; Chloro-APB hydrobromide

    		 Dopamine Receptor Neurological Disease
    SKF-82958 ((±)-SKF 82958) hydrobromide is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 hydrobromide induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM) .
    SKF-82958 hydrobromide
  • HY-117238
    Ketomethylenebestatin

    		Aminopeptidase Others
    Ketomethylenebestatin is an aminopeptidase (AP) inhibitor and an analog of the natural aminopeptidase inhibitor Bestatin (HY-B0134) with IC50 of 56 μM, 752 μM and 0.39 μM for AP-B, AP-M and Leu-AP, respectively .
    Ketomethylenebestatin
  • HY-117436
    R(+)-6-Bromo-APB hydrobromide

    		Dopamine Receptor Cardiovascular Disease
    R(+)-6-Bromo-APB hydrobromide is a dopamine (DA) agonist. R(+)-6-Bromo-APB hydrobromide increased the expression of µ opioid receptor (MOR) mRNA in the nucleus accumbens .
    R(+)-6-Bromo-APB hydrobromide
  • HY-100781A
    L-AP4

    L-APB

    		 mGluR Neurological Disease
    L-AP4 (L-APB) is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively .
    L-AP4
  • HY-100781B
    L-AP4 monohydrate

    L-APB monohydrate

    		 mGluR Neurological Disease
    L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively .
    L-AP4 monohydrate
  • HY-100781
    D-AP4

    D-APB; D-2-Amino-4-phosphonobutyric acid

    		 iGluR Neurological Disease
    D-AP4 (D-APB; D-2-Amino-4-phosphonobutyric acid), a phosphono analogue of glutamate, is an NMDA broad spectrum excitatory amino acid receptor antagonist. D-AP4 also is an agonist for a quisqualate-sensitized AP6 site in hippocampus. D-AP4 inhibits AMPA receptor-stimulated 57Co 2+ influx in cultured cerebellar granule cells (IC50 ≥ 100 μM) .
    D-AP4
  • HY-161697
    hCAIX-IN-20

    		Carbonic Anhydrase Cancer
    hCAIX-IN-20 (compound APBS-5m) is a potent inhibitor of carbonic anhydrase IX (hCA IX), with the Ki of 2.7 nM. hCAIX-IN-20 plays an important role in cancer research .
    hCAIX-IN-20
  • HY-10435
    SKF-82958

    (±)-SKF-82958; Chloro-APB

    		 Dopamine Receptor Neurological Disease
    SKF-82958 ((±)-SKF 82958) is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM) .
    SKF-82958

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