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Results for "

CCL4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Apoptosis (3) Autophagy (2) c-Myc (2) CCR (1) ERK (1) Ferroptosis (1) Isotope-Labeled Compounds (1) NOD-like Receptor (NLR) (1) PGE synthase (1) Phosphodiesterase (PDE) (1) Phospholipase (1) PI3K (2) PROTACs (1) Small Interfering RNA (siRNA) (3) TrxR (1) VEGFR (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (15) Metabolic Disease (6) Neurological Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122951

Eburicoic acid	Others	Cardiovascular Disease
Eburicoic acid protects the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms . And Eburicoic acid has antidiabetic and antihyperlipidemic effects .

HY-N2998

Ganoderenic acid A	Others	Metabolic Disease
Ganoderenic acid A is a lanostane-type triterpene. Ganoderenic acid A is a potent inhibitor of β-glucuronidase. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury .

HY-N2358

Blumeatin	Others	Inflammation/Immunology
Blumeatin, isolated from Blumea balsamifera DC, could protect liver against injury induced by CCl4 and thioacetamide (TAA) .

HY-RS02102

CCL4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL4 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL4 Human Pre-designed siRNA Set A CCL4 Human Pre-designed siRNA Set A

HY-RS02103

CCL4L1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL4L1 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL4L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL4L1 Human Pre-designed siRNA Set A CCL4L1 Human Pre-designed siRNA Set A

HY-RS02104

CCL4L2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL4L2 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL4L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL4L2 Human Pre-designed siRNA Set A CCL4L2 Human Pre-designed siRNA Set A

HY-N9173

Cupressuflavone	Others	Inflammation/Immunology
Cupressuflavone is a natural product that can be found in Cupressus macrocarpa. Cupressuflavone exhibits anti-inflammatory and antiulcerogenic activities. Cupressuflavone also show protective effects against CCl₄-induced hepato- and nephrotoxicity in mice .

HY-121944

Ricinine	Others	Others
Ricinine exhibits hepatoprotection in CCl4 -induced liver damage .

HY-121944S

Ricinine-d3	Isotope-Labeled Compounds	Others
Ricinine-d₃ is the deuterium labeled Ricinine. Ricinine exhibits hepatoprotection in CCl4 -induced liver damage[1].

HY-N3315

Massonianoside B	Others	Inflammation/Immunology
Massonianoside B is an antioxidant, which can be isolated from Cedrus deodara pine needle. Massonianoside B exhibits radicals scavenging capacities, and restores CCL4-impaired activity of antioxidant enzymes .

HY-N0823

Lithospermic acid (+)-Lithospermic acid	Others	Inflammation/Immunology
Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl₄)-induced acute liver damage in vitro and in vivo .

HY-133019

ATX inhibitor 5	Phosphodiesterase (PDE)	Inflammation/Immunology
ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC₅₀ of 15.3 nM. ATX inhibitor 5 shows anti-hepatofibrosis effects and reduces CCl4-induced hepatic fibrosis level prominently .

HY-N2109

Macranthoidin A	Others	Metabolic Disease
Macranthoidin A is an orally active saponin from Flos Lonicerae. Macranthoidin A possess protection effects on hepatic injury caused by Acetaminophen, Cd, and CCl4, and conspicuous depressant effects on swelling of ear croton oil .

HY-N0823R

Lithospermic acid (Standard)	Others	Inflammation/Immunology
Lithospermic acid (Standard) is the analytical standard of Lithospermic acid. This product is intended for research and analytical applications. Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo .

HY-146350

TrxR-IN-4	TrxR	Cancer
TrxR-IN-4 (Compound 1b) is a potent inhibitor of TrxR. TrxR-IN-4 induces HepG2 cells apoptosis by activating the endoplasmic reticulum stress (ERS). TrxR-IN-4 improves the CCl4-induced liver damage in vivo by down-regulation of TrxR expression and inflammation level .

HY-121271

Kadsurin	Others	Inflammation/Immunology
Kadsurin, a natural compound from the stems of Kadsura heteroclita (Schizandraceae), results in significant decreases of CCL₄- induced lipid-peroxidation products, such as thiobarbituric acid reactive substances (TBA-RS), conjugated dienes and fluorescent products in the liver of mice .

HY-N2082

Isorhamnetin 3-O-galactoside 1 Publications Verification Cacticin	Others	Cardiovascular Disease Inflammation/Immunology
Isorhamnetin 3-O-galactoside (Cacticin), a flavonoid glycoside isolated from Artemisia capillaris Thunberg, which ameliorates CCl4-induced hepatic damage by enhancing the anti-oxidative defense system and reducing the inflammatory signaling pathways. Isorhamnetin 3-O-galactoside (Cacticin) has antithrombotic and anti-inflammatory activities .

HY-N12016

Fulvotomentoside B	Others	Metabolic Disease
Fulvotomentoside B is a saponin isolated from Lactobacillus flavus. Fulvotomentoside compounds can significantly reduce serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) levels in mice poisoned by CCl₄, d-galactosamine (d-gal) and acetaminophen, and significantly alleviate liver pathology. damage .

HY-N2109R

Macranthoidin A (Standard)	Others	Metabolic Disease
Macranthoidin A (Standard) is the analytical standard of Macranthoidin A. This product is intended for research and analytical applications. Macranthoidin A is an orally active saponin from Flos Lonicerae. Macranthoidin A possess protection effects on hepatic injury caused by Acetaminophen, Cd, and CCl4, and conspicuous depressant effects on swelling of ear croton oil .

HY-145801

XT2	Others	Inflammation/Immunology
XT2 is a potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK) with an IC₅₀ of 9.1 nM. XT2 suppresses CCl4-induced upregulation of ALT, a key biomarker of acute liver injury. XT2 also decreases immune cell infiltration into the injured liver tissue. XT2 has the potential for the research of liver inflammatory diseases . XT2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N7327

Ochnaflavone	Phospholipase	Inflammation/Immunology
Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC₅₀ of 3.45 µM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC₅₀ of 7.16 µM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases .

HY-163897

PROTAC NCOA4 degrader-1	PROTACs Ferroptosis	Inflammation/Immunology
PROTAC NCOA4 degrader-1 (Compound V3) is a PROTAC *NCOA4* degrader (DC₅₀: 3 nM in HeLa cells). PROTAC NCOA4 degrader-1 is a ferroptosis inhibitor. PROTAC NCOA4 degrader-1 reduces NCOA4 levels and downregulates intracellular ferrous iron (Fe ²⁺) levels. PROTAC NCOA4 degrader-1 ameliorates liver damage in a CCl₄-induced acute liver injury model. (Red: NCOA4 ligand (HY-149457). Black: linker (HY-163903). Blue: VHL ligand (HY-138678B)) .

HY-B0498

Bindarit Maximum Cited Publications 14 Publications Verification AF2838	CCR	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins *MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL*23. Bindarit also has anti-inflammatory activity .

HY-N0330

Momordin Ic 3 Publications Verification	Apoptosis Autophagy PI3K c-Myc	Metabolic Disease Inflammation/Immunology Cancer
Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, SENP1/c-MYC signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl₄ (HY-Y0298) induced hepatotoxicity and anti-tumor activity .

HY-152293

EVT801	VEGFR ERK	Cancer
EVT801 is an orally active and selective inhibitor of VEGFR-3 (IC₅₀=11 nM), which has antitumor effects. EVT801 inhibits not only VEGF-C-induced human endothelial cell proliferation, but also tumor (lymphatic) angiogenesis in tumor mouse models. EVT801 can reduce tumor hypoxia, immunosuppressive cytokines (CCL4, CCL5) and myeloid derived suppressor cells (MDSC) production. EVT801 has synergistic effect with immune checkpoint therapy (ICT), which improves ICT response rate and has better inhibitory effect on cancer mouse models . EVT801 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N0330R

Momordin Ic (Standard)	Apoptosis Autophagy PI3K c-Myc	Metabolic Disease Inflammation/Immunology Cancer
Momordin Ic (Standard) is the analytical standard of Momordin Ic. This product is intended for research and analytical applications. Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, SENP1/c-MYC signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl4 (HY-Y0298) induced hepatotoxicity and anti-tumor activity .

HY-149202

UT-11	PGE synthase	Inflammation/Immunology
UT-11 is a potent and brain-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC₅₀s of 0.10 μM and 2.00 μM for inhibiting PGE₂ production in human (SK-N-AS) and murine (BV2) cells, respectively .

HY-N0373

Licochalcone B 5 Publications Verification	Amyloid-β Apoptosis NOD-like Receptor (NLR)	Neurological Disease
Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (₄₂) self-aggregation (IC₅₀=2.16 μM) and disaggregate pre-formed Aβ₄₂ fibrils, reduce metal-induced Aβ₄₂ aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction ^[4].

Cat. No.	Product Name	Category	Target	Chemical Structure