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XT2 is a potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK) with an IC50 of 9.1 nM. XT2 suppresses CCl4-induced upregulation of ALT, a key biomarker of acute liver injury. XT2 also decreases immune cell infiltration into the injured liver tissue. XT2 has the potential for the research of liver inflammatory diseases. XT2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

XT2 Chemical Structure

XT2 Chemical Structure

CAS No. : 2582816-37-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 709 In-stock
Solution
10 mM * 1 mL in DMSO USD 709 In-stock
Solid
1 mg USD 340 In-stock
5 mg USD 850 In-stock
10 mg USD 1300 In-stock
25 mg USD 2650 In-stock
50 mg USD 4250 In-stock
100 mg USD 6900 In-stock
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Based on 1 publication(s) in Google Scholar

XT2 Related Antibodies

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Description

XT2 is a potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK) with an IC50 of 9.1 nM. XT2 suppresses CCl4-induced upregulation of ALT, a key biomarker of acute liver injury. XT2 also decreases immune cell infiltration into the injured liver tissue. XT2 has the potential for the research of liver inflammatory diseases[1]. XT2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Molecular Weight

379.41

Formula

C19H14FN5OS
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

FC1=CC=C(C#C[C@@](O)(C2=NC=CS2)C)C=C1C(C3=N4)=CNC3=CN=C4N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (131.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6357 mL 13.1784 mL 26.3567 mL
5 mM 0.5271 mL 2.6357 mL 5.2713 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6357 mL 13.1784 mL 26.3567 mL 65.8918 mL
5 mM 0.5271 mL 2.6357 mL 5.2713 mL 13.1784 mL
10 mM 0.2636 mL 1.3178 mL 2.6357 mL 6.5892 mL
15 mM 0.1757 mL 0.8786 mL 1.7571 mL 4.3928 mL
20 mM 0.1318 mL 0.6589 mL 1.3178 mL 3.2946 mL
25 mM 0.1054 mL 0.5271 mL 1.0543 mL 2.6357 mL
30 mM 0.0879 mL 0.4393 mL 0.8786 mL 2.1964 mL
40 mM 0.0659 mL 0.3295 mL 0.6589 mL 1.6473 mL
50 mM 0.0527 mL 0.2636 mL 0.5271 mL 1.3178 mL
60 mM 0.0439 mL 0.2196 mL 0.4393 mL 1.0982 mL
80 mM 0.0329 mL 0.1647 mL 0.3295 mL 0.8236 mL
100 mM 0.0264 mL 0.1318 mL 0.2636 mL 0.6589 mL
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XT2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XT22582816-37-1XT 2XT-2OthersNF-κB-inducing kinaseALTacute liver injuryinflammatory diseasesInhibitorinhibitorinhibit

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