2. PROTAC Apoptosis
  3. PROTACs Ferroptosis
  4. PROTAC NCOA4 degrader-1

PROTAC NCOA4 degrader-1 (Compound V3) is a PROTAC NCOA4 degrader (DC50: 3 nM in HeLa cells). PROTAC NCOA4 degrader-1 is a ferroptosis inhibitor. PROTAC NCOA4 degrader-1 reduces NCOA4 levels and downregulates intracellular ferrous iron (Fe2+) levels. PROTAC NCOA4 degrader-1 ameliorates liver damage in a CCl4-induced acute liver injury model. (Red: NCOA4 ligand (HY-149457). Black: linker (HY-163903). Blue: VHL ligand (HY-138678B)).

For research use only. We do not sell to patients.

PROTAC NCOA4 degrader-1 Chemical Structure

PROTAC NCOA4 degrader-1 Chemical Structure

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PROTAC NCOA4 degrader-1 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC NCOA4 degrader-1 (Compound V3) is a PROTAC NCOA4 degrader (DC50: 3 nM in HeLa cells). PROTAC NCOA4 degrader-1 is a ferroptosis inhibitor. PROTAC NCOA4 degrader-1 reduces NCOA4 levels and downregulates intracellular ferrous iron (Fe2+) levels. PROTAC NCOA4 degrader-1 ameliorates liver damage in a CCl4-induced acute liver injury model. (Red: NCOA4 ligand (HY-149457). Black: linker (HY-163903). Blue: VHL ligand (HY-138678B))[1].

Molecular Weight

1141.43

Formula

C62H80N10O9S
Appearance

Solid

Color

White to off-white

SMILES

CN1CCN(C2=CC3=C(N=C(C4=CC(N5CCC6=CC(OCCOCCOCCOCCNC(CCCC(N[C@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C=C8)C9=C(N=CS9)C)=O)=O)=O)=O)=CC=C6C5)=CC=C4)N3)C=C2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (87.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8761 mL 4.3805 mL 8.7609 mL
5 mM 0.1752 mL 0.8761 mL 1.7522 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8761 mL 4.3805 mL 8.7609 mL 21.9023 mL
5 mM 0.1752 mL 0.8761 mL 1.7522 mL 4.3805 mL
10 mM 0.0876 mL 0.4380 mL 0.8761 mL 2.1902 mL
15 mM 0.0584 mL 0.2920 mL 0.5841 mL 1.4602 mL
20 mM 0.0438 mL 0.2190 mL 0.4380 mL 1.0951 mL
25 mM 0.0350 mL 0.1752 mL 0.3504 mL 0.8761 mL
30 mM 0.0292 mL 0.1460 mL 0.2920 mL 0.7301 mL
40 mM 0.0219 mL 0.1095 mL 0.2190 mL 0.5476 mL
50 mM 0.0175 mL 0.0876 mL 0.1752 mL 0.4380 mL
60 mM 0.0146 mL 0.0730 mL 0.1460 mL 0.3650 mL
80 mM 0.0110 mL 0.0548 mL 0.1095 mL 0.2738 mL
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PROTAC NCOA4 degrader-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC NCOA4 degrader-1PROTACsFerroptosisacute liver injuryInhibitorinhibitorinhibit

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