GPC3

By Targets:	Drug-Linker Conjugates for ADC (1) Glycoprotein VI (2) Small Interfering RNA (siRNA) (1) Topoisomerase (1)
By Research Areas:	Cancer (2)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99013

Codrituzumab 1 Publications Verification GC33; RO5137382	Glycoprotein VI	Cancer
Codrituzumab (GC33) is a humanized monoclonal antibody targeting human *GPC3* (glypican-3), with high affinity (K_d of 0.673 nM). GPC3 is an oncofetal protein expressed on the cell surface of hepatocellular carcinoma (HCC). Codrituzumab induces antibody-dependent cellular cytotoxicity (ADCC) and inhibits tumor growth ^[3].

HY-153360

MC-GGFG-AM-(10Me-11F-Camptothecin)	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human *GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1* inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells .

HY-RS05628

GPC3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GPC3 Human Pre-designed siRNA Set A contains three designed siRNAs for GPC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GPC3 Human Pre-designed siRNA Set A GPC3 Human Pre-designed siRNA Set A

HY-P990840

*Anti-GPC3* Antibody (YP7)**	Glycoprotein VI	Others
Anti-GPC3 Antibody (YP7) is a kind of mouse IgG1, κ chimeric antibody, targeting to human *GPC3. The recommend isotype control of Anti-GPC3* Antibody (YP7): Mouse IgG1 kappa, Isotype Control (HY-P99977).

Cat. No.	Product Name	Target	Research Area

HY-P99013

Codrituzumab 1 Publications Verification GC33; RO5137382	Glycoprotein VI	Cancer
Codrituzumab (GC33) is a humanized monoclonal antibody targeting human *GPC3* (glypican-3), with high affinity (K_d of 0.673 nM). GPC3 is an oncofetal protein expressed on the cell surface of hepatocellular carcinoma (HCC). Codrituzumab induces antibody-dependent cellular cytotoxicity (ADCC) and inhibits tumor growth ^[3].

HY-P990840

*Anti-GPC3* Antibody (YP7)**	Glycoprotein VI	Others
Anti-GPC3 Antibody (YP7) is a kind of mouse IgG1, κ chimeric antibody, targeting to human *GPC3. The recommend isotype control of Anti-GPC3* Antibody (YP7): Mouse IgG1 kappa, Isotype Control (HY-P99977).

Recombinant Proteins Recommended:

GPC-3

Species:	Human (12) Mouse (2) Cynomolgus (1)
Tag:	His (11) Avi (1) Myc (1) Fc (4)
Source:	HEK293 (14) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70487

	*Glypican-3/GPC3* Protein, Human (HEK293, His)** 1 Publications Verification Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5	Human	HEK293
	The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. Glypican-3/GPC3 Protein, Human (HEK293, His) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70872

	*Glypican-3/GPC3* Protein, Mouse (HEK293, His)** Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5	Mouse	HEK293
	GPC3 is a cell surface proteoglycan that regulates Hedgehog and Wnt signaling. Glypican-3/GPC3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Glypican-3/GPC3 Protein, Mouse (HEK293, His) is 533 a.a., with molecular weight of 40 & 72-150 kDa, respectively.

HY-P70367

	*Glypican-3/GPC3* Protein, Human (HEK293, Fc, solution)** rHuGlypican-3/GPC3, Fc; Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5	Human	HEK293
	The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. Glypican-3/GPC3 Protein, Human (HEK293, Fc, solution) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74122

	*Glypican-3/GPC3* Protein, Human (S495A, HEK293, Fc)** Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5	Human	HEK293
	The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. Glypican-3/GPC3 Protein, Human (S495A, HEK293, Fc) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P72628

	*Glypican-3/GPC3* Protein, Cynomolgus (HEK293, His)** Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5	Cynomolgus	HEK293
	GPC3 is a member of the heparan sulfate proteoglycans (HSPGs), and attaches to the cell surface by a glycosylphosphatidylinositol anchor. GPC3 is overexpressed in hepatocellular carcinoma (HCC) and can be used as a tumor marker for HCC. Membrane GPC3 can interact with several growth factors to promote the binding of growth factors to their receptors. GPC3 can form a complex with Wnt and activates Wnt signaling, leading to the HCC growth. In addition, GPC3 is also involved in the pathogenesis of Simpson-Golabi-Behmel overgrowth syndrome, regulates cell growth, regulates embryonic and fetal development. Glypican-3/GPC3 Protein, Cynomolgus (HEK293, His) is the recombinant Cynomolgus-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Glypican-3/GPC3 Protein, Cynomolgus (HEK293, His) is 535 a.a., with molecular weight of 38 & 65-120 kDa, respectively.

HY-P70367A

	*Glypican-3/GPC3* Protein, Human (HEK293, Fc)** rHuGlypican-3/GPC3, Fc; Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5	Human	HEK293

HY-P77548

	*Glypican-3/GPC3* Protein, Human (Biotinylated, HEK293, His)** Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5	Human	HEK293
	The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. Glypican-3/GPC3 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70487G

	*GMP Glypican-3/GPC3* Protein, Human (HEK293, His)** Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5	Human	HEK293
	The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. GMP Glypican-3/GPC3 Protein, Human (HEK293, His) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73078

	*Glypican-3/GPC3* Protein, Mouse (sf9, His)** Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5	Mouse	Sf9 insect cells
	GPC3 is a cell surface proteoglycan that regulates Hedgehog and Wnt signaling. Glypican-3/GPC3 Protein, Mouse (sf9, His) is the recombinant mouse-derived Glypican-3/GPC3 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P700414

	*Glypican-3/GPC3* Protein, Human (HEK293, His-Myc)** Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5	Human	HEK293
	The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. Glypican-3/GPC3 Protein, Human (HEK293, His-Myc) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with N-Myc, N-6*His labeled tag and G537R, , , , mutation.

HY-P72373

	*Glypican-3/GPC3* Protein, Human (Biotinylated, HEK293, His-Avi)** Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5	Human	HEK293
	The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. Glypican-3/GPC3 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

HY-P701291

	*FITC-Labeled Glypican 3/GPC3* Protein, Human (HEK293, Fc)** GPC3; OCI5; Glypican-3; GTR2-2; MXR7; DGSX; SDYS ; SGB; SGBS; SGBS1	Human	HEK293
	The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. FITC-Labeled Glypican 3/GPC3 Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled Glypican 3/GPC3 protein, expressed by HEK293 , with Fc labeled tag.

HY-P701292

	*FITC-labeled Glypican-3/GPC3* Protein, Human (HEK293, His)** GPC3; OCI5; Glypican-3; GTR2-2; MXR7; DGSX; SDYS ; SGB; SGBS; SGBS1	Human	HEK293
	The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. FITC-labeled Glypican-3/GPC3 Protein, Human (HEK293, His) is the recombinant human-derived FITC-labeled Glypican-3/GPC3 protein, expressed by HEK293 , with His labeled tag.

HY-P701293

	*PE-labeled Glypican-3/GPC3* Protein, Human (HEK293, His)** GPC3; OCI5; Glypican-3; GTR2-2; MXR7; DGSX; SDYS ; SGB; SGBS; SGBS1	Human	HEK293
	The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. PE-labeled Glypican-3/GPC3 Protein, Human (HEK293, His) is the recombinant human-derived PE-labeled Glypican-3/GPC3 protein, expressed by HEK293 , with His labeled tag.

HY-P78674

	*Glypican-3/GPC3* Protein, Human (S359F, HEK293, His)** GPC3; OCI5; Glypican-3; GTR2-2; MXR7; DGSX; SDYS ; SGB; SGBS; SGBS1	Human	HEK293
	The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. Glypican-3/GPC3 Protein, Human (S359F, HEK293, His) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-His labeled tag and S359F, , , , mutation.

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HY-P82706

	Glypican 3 Antibody (YA2451) GPC3; OCI5; Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7	WB, FC	Human

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HY-RS05628

GPC3 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
GPC3 Human Pre-designed siRNA Set A contains three designed siRNAs for GPC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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