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Results for "

LD50

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (1) AMPK (1) Antibiotic (7) Apoptosis (7) Autophagy (1) Bacterial (11) Biochemical Assay Reagents (3) Calcium Channel (1) Carbonic Anhydrase (1) Cholinesterase (ChE) (2) ClpP (1) COX (1) DNA Methyltransferase (1) DNA/RNA Synthesis (1) EGFR (3) Endogenous Metabolite (1) Farnesyl Transferase (1) Fungal (2) GSK-3 (1) IGF-1R (1) JAK (2) nAChR (1) NF-κB (2) Parasite (8) PI3K (1) SARS-CoV (2) Sodium Channel (2)
By Research Areas:	Cancer (16) Cardiovascular Disease (3) Endocrinology (1) Infection (26) Inflammation/Immunology (6) Metabolic Disease (3) Neurological Disease (4)
Click Chemistry:	Azide (1)
Oligonucleotides:	Release-retarding Agents (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-135286A

(+)-Neomenthol	Parasite	Infection
(+)-Neomenthol is a potent miticide. (+)-Neomenthol shows acaricidal activitie with *LD₅₀* values of 0.32, 0.256 µg/mL for Dermatophagoides farinae and Dermatophagoides pteronyssinus, respectively .

HY-W099757

(±)-Coniine hydrochloride 2-Propylpiperidine hydrochloride	nAChR	Neurological Disease
(±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an *EC₅₀* value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD₅₀ value of 7.7 mg/kg .

HY-D1163

Chromium(III) acetate 1 Publications Verification Chromium acetate; Chromic acetate; Chromium triacetate	AMPK	Metabolic Disease
Chromium(III) acetate (Chromic acetate) is an AMPK inhibitor that promotes lipogenesis by inhibiting AMPK phosphorylation. Chromium(III) acetate has low toxicity in mammals, with an *LD₅₀* of 2365 mg/kg in rats .

HY-129208

Viridicatumtoxin	Antibiotic Fungal	Infection
Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a *LD₅₀* of 122.4 mg/kg in rats.

HY-126715

Pimelautide RP 44102	Others	Inflammation/Immunology
Pimelautide (RP 44102), a desmuramyl peptidolipid, is an adjuvant. Pimelautide shows a LD₅₀ of 410 mg/kg (i.v, mouse) .

HY-114614

Clenpirin	Parasite	Infection
Clenpirin is a insecticide against cattle ticks Boophilus microplus. Clenpirin exhibits slightly toxicity to rats with LD₅₀ of 3050 mg/kg .

HY-157162

Insecticidal agent 5	Cholinesterase (ChE)	Others
Insecticidal agent 5 (compound 8) is an AChE-targeting insecticide with an LD50 of 27.65 ppm against the cotton leafworm Spodoptera littoralis .

HY-124132

Autophagy-IN-4	Autophagy	Cancer
Autophagy-IN-4 (Compound 34) is an autophagy inhibitor, with an *EC₅₀* of 0.5 μM and a LD50 of 27 μM for U2OS cells .

HY-128430

Farnesyl acetate	Others	Infection
Farnesyl acetate is a sesquiterpene isolated from the leaves of Amomum gagnepainii. Farnesyl acetate has significant toxicity against red palm weevil larvae with a LD₅₀ of 7867 ppm .

HY-103272

iMAC2	Apoptosis Bacterial	Others
iMAC2 is a potent MAC inhibitor with an *IC₅₀* of 28 nM and an *LD₅₀* of 15000 nM. iMAC2 shows anti-apoptotic effect. iMAC2 blocks cytochrome c release .

HY-138100

Hyalodendrin (+)-Hyalodendrin	Fungal	Infection
Hyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice .

HY-N0531

Filixic acid ABA	Parasite	Infection
Filixic acid ABA is a molluscicidal agent against B. peregrina adult snails, with an *LD₅₀* of 8.40 ppm. Filixic acid ABA shows 100% mortality of B. peregrina at 15 ppm .

HY-N10695

Celangulatin C	Parasite	Infection
Celangulatin C is an insecticidal sesquiterpene polyol ester, that can be isolated from the root bark of Pseudolarix kaempferi. Celangulatin C shows *LD₅₀* against Mythimna separata of 280.4 μg/mL .

HY-B0824

Bifenthrin 1 Publications Verification	Sodium Channel	Neurological Disease
Bifenthrin is a synthetic pyrethroid insecticide. Bifenthrin prolongs the opening time of Nav1.8 sodium channels, leading to membrane depolarization and conductance block in the insect nervous system, thereby disrupting neural function. Bifenthrin was effective in inhibiting A. gambiae (LD₅₀=0.15 ng/mg) and C. quinquefasciatus (LD₅₀=0.16 ng/mg). Bifenthrin has good lethality against susceptible and resistant mosquitoes and is very effective in inhibiting blood sucking and can be developed as a mosquito-removal netting material .

HY-110073

iMAC2 hydrochloride	Apoptosis	Inflammation/Immunology Cancer
iMAC2 hydrochloride is a potent MAC (mitochondrial apoptosis-induced channel) inhibitor, with an *IC₅₀* of 28 nM and a *LD₅₀* of 15000 nM. iMAC2 hydrochloride shows anti-apoptotic effect. iMAC2 hydrochloride blocks cytochrome c release .

HY-16172

DMAPT Dimethylamino Parthenolide	NF-κB	Cancer
DMAPT (Dimethylamino Parthenolide), an analogue of Parthenolide (PTL), is an oral active NF-κB inhibitor, with a LD₅₀ of 1.7 μM for cell population in AML cells. Has potential anti-cancer and anti-metastatic effect .

HY-16172A

(S)-DMAPT (S)-Dimethylamino Parthenolide	NF-κB	Cancer
(S)-DMAPT (Dimethylamino Parthenolide), an analogue of Parthenolide (PTL), is an oral active NF-κB inhibitor, with a LD₅₀ of 1.7 μM for cell population in AML cells. Has potential anti-cancer and anti-metastatic effect .

HY-126645

Atelopidtoxin	Sodium Channel	Cardiovascular Disease
Atelopidtoxin (zetekitoxin) is a toxin (LD₅₀=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel .

HY-121182

Chalcomycin	Antibiotic Bacterial	Infection
Chalcomycin is a macrolide antibiotic, which exhibits antimicrobial activities against gram-positive Staphylococcus aureus and Streptococcus pyogenes. Chalcomycin protects mice from infection with a variety of staphylococci and streptococc, without significant toxicity (LD₅₀ >2500 mg/kg) .

HY-135526

Demethoxyviridiol Desmethoxyviridiol	Others	Infection
Demethoxyviridiol is a mycotoxin originally isolated from N. hinnuleum. Demethoxyviridiol induces lethality in day-old cockerels (LD₅₀=4.2 mg/kg). Demethoxyviridiol is also an inhibitor of phosphatidylinositol 3-kinase (PI3K).

HY-121104

Bactobolin	Antibiotic Bacterial	Infection Cancer
Bactobolin is an antibiotic, which inhibits Escherichia coli, Salmonella, Shigella, Staphylococcus and Bacillus subtilis, with MICs of 0.3-6.25 μg/mL. Bactobolin exhibits antitumor efficacy against leukemia, with LD₅₀ of 6.25-12.5 mg/kg .

HY-N10697

Angulatin G Celangulatin E	Parasite	Infection
Angulatin G (Celangulatin E) is an insecticidal sesquiterpene polyol ester with a β-dihydroagarofuran sesquiterpene skeleton, which can be isolated from the root bark of Celastrus angulatus. Angulatin G shows *LD₅₀* against Mythimna separata of 1656.4 μg/mL .

HY-127165

Velnacrine HP 029 free base; Hydroxytacrine	Cholinesterase (ChE)	Neurological Disease
Velnacrine (HP 029 free base) is an inhibitor for acetylcholinesterase (AChE), with an *IC₅₀* of 3.27 μM. Velnacrine reverses the Scopolamine (HY-N0296)-induced amnesia in rat models, and exhibits acute toxicity with LD₅₀ of 65 mg/kg .

HY-116498

Penigequinolone A	Others	Infection
Penigequinolone A is an alkaloid isolated from Penicillium. It is lethal to P. penetrans (LD50=100 mg/L) but has no effect on C. elegans at concentrations up to 1000 mg/L.1 Penigequinolone A also accelerates the root growth of rice seedlings in a dose-dependent manner.

HY-120367

DTP348	Carbonic Anhydrase	Cancer
DTP348 is an inhibitor for carbonic anhydrase IX with a K_i of 8.3 nM in vitro and an *IC₅₀* of 19.26 μM in Xenopus oocytes. DTP348 exhibits slight toxicity in zebrafish embryos with *LD₅₀* of 3.5 mM. DTP348 can be used in the anti-cancer research .

HY-126788

Antibiotic DC 102 DC 102	Antibiotic	Infection Metabolic Disease
Antibiotic DC 102 is a new glycosidic pyrrole(1,4)benzodiazepine antibiotic with a MIC value of 42 μg/mL target Bacillus subtilis No. 10707. Antibiotic DC 102 has an *LD₅₀* value of 1.5mg/mL(i.p) in mouse .

HY-78086

m-Tolualdehyde 3-MethylbenzaLDehyde	Endogenous Metabolite Bacterial	Infection
m-Tolualdehyde (3-Methylbenzaldehyde) is a compound that can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a *LD₅₀* of 1.97 μg/cm ³ .

HY-B1869

Metsulfuron-methyl	Others	Others
Metsulfuron-methyl is a systemic sulfonylurea herbicide that has been widely used to control broadleaf weeds and annual grasses in rice, corn, wheat, and barley. Metsulfuron-methyl exhibits high herbicidal activity and low mammalian toxicity, with an **LD₅₀ for rats exceeding 5000 mg/kg .**

HY-W663230

Eugenitin	Parasite	Infection
Eugenitin is a polyketide isolated from the fungus Mycoleptodiscus indicus that is related to the South American medicinal plant. Eugenitin inhibits Leishmania major with *LD₅₀*=39.9 μM. Eugenitin has low cytotoxicity (IC₅₀ >131 μM) against several human cancer cell lines .

HY-137139

10'-Desmethoxystreptonigrin	Antibiotic Bacterial Farnesyl Transferase	Infection Cancer
10'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an *IC₅₀* of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD₅₀ is 8.8 mg/kg) .

HY-W024485

SARS-CoV-2-IN-86	SARS-CoV	Infection
SARS-CoV-2-IN-86 (Compound 2734589) is a dual inhibitor of the methyltransferases nsp14 and nsp16 of SARS-CoV-2. SARS-CoV-2-IN-86 exhibits low toxicity with a LD₅₀ of 700 mg/kg according to toxicity analysis predict .

HY-D1005A16

Poloxamer 235 (P85) PEG-PPG-PEG, 4600 (Averag)	Biochemical Assay Reagents	Others
Poloxamer 235 P85 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4600. Poloxamer 235 P85 exhibits acute and subchronic toxicity in albino rats with an oral *LD₅₀* of >34.6 g/kg. Poloxamer 235 P85 induces ocular irritation in rabbits .

HY-152927

Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)	Biochemical Assay Reagents	Others
Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility agents. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD₅₀ >2.5 g/kg .

HY-N0381

Maackiain DL-Maackiain	Parasite Apoptosis	Infection
Maackiain (DL-Maackiain) is isolated from Maackia amurensis Rupr.et Maxim. Maackiain (DL-Maackiain) is a larvicidal agent against Aedes aegypti mosquito.xp Parasitol with a *LD₅₀* of 21.95 µg/mL . Maackiain (DL-Maackiain) induces fragmentations of DNA to oligonucleosomal-sized fragments that like a characteristic of apoptosis in the HL-60 cells .

HY-162482

EGFR kinase inhibitor 5	EGFR Apoptosis	Inflammation/Immunology Cancer
EGFR kinase inhibitor 5 (Compound 4c) is an orally active inhibitor for epidermal growth factor receptor (EGFR) kinase, with *IC₅₀* of 18.35 μM. EGFR kinase inhibitor 5 induces apoptosis. EGFR kinase inhibitor 5 exhibits anticancer and anti-inflammatory activity with low toxicity (LD₅₀ range: 500-2000 mg/kg) .

HY-162483

EGFR kinase inhibitor 6	EGFR Apoptosis	Inflammation/Immunology Cancer
EGFR kinase inhibitor 6 (Compound 4b) is an orally active inhibitor for epidermal growth factor receptor (EGFR) kinase, with *IC₅₀* of 24.34 μM. EGFR kinase inhibitor 6 induces apoptosis. EGFR kinase inhibitor 6 exhibits anticancer and anti-inflammatory activity with low toxicity (LD₅₀ range: 500-2000 mg/kg) .

HY-N9495

(-)-trans-Myrtanol	Bacterial	Infection
(-)-trans-Myrtanol is an antimicrobial and acaricide agent. (-)-trans-Myrtanol exhibits potent antimicrobial activities against harmful intestinal bacteria. (-)-trans-Myrtanol shows acaricidal activities for D. farinae, D. pteronyssinus, T. putrescentiae with *LD₅₀* values of 2.30 µg/cm ², 2.22 µg/cm ², 12.95 µg/cm ², respectively .

HY-129278

Lunarine	Parasite	Infection Cardiovascular Disease Neurological Disease
Lunarine is an alkaloid, which can be isolated from the seeds of kale (Lunaria annua). Lunarine lowers the blood pressure, stimulates small intestinal motility, inhibits spontaneous contractions of uterus and nervous system, and exhibits an acute toxicity with LD₅₀ of 62.3 mg/kg in dogs and rabbits. Lunarine exhibits antiparasitic activity through a competitive inhibition of protozoan oxidoreductase trypanothione reductase (TryR) with K_i of 304 μM .

HY-B1869R

Metsulfuron-methyl (Standard)	Others	Others
Metsulfuron-methyl (Standard) is the analytical standard of Metsulfuron-methyl. This product is intended for research and analytical applications. Metsulfuron-methyl is a systemic sulfonylurea herbicide that has been widely used to control broadleaf weeds and annual grasses in rice, corn, wheat, and barley. Metsulfuron-methyl exhibits high herbicidal activity and low mammalian toxicity, with an LD50 for rats exceeding 5000 mg/kg .

HY-130596

DC-86-M	Antibiotic Bacterial	Infection Cancer
DC-86-M is an antibiotic, which can be isolated from Streptomyces luteogriseus. DC-86-M exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Vibrio anguillarum, and Proteus vulgaris, with MIC <1 μg/mL. DC-86-M exhibits antitumor activity against mouse sarcoma 180 with LD₅₀ of 25 mg/kg .

HY-D1005A6

Poloxamer 124 (L44) PEG-PPG-PEG, 2200 (Averag)	Biochemical Assay Reagents	Others
Poloxamer 124 L44 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2200. Poloxamer 124 L44 reveals toxicity with an oral *LD₅₀* of 5 g/kg in albino rats. Poloxamer 124 L44 causes ocular irritation. Poloxamer 124 L44 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-163923

Apoptosis inducer 24	Apoptosis	Cancer
Apoptosis inducer 24 (Compound 4) inhibits the proliferation of gastric cancer cells with *IC₅₀* of 1.2-4.8 μM. Apoptosis inducer 24 arrests cell cycle at G2/M phase, induces apoptosis in cell BGC-823, and causes mitochondrial dysfunction. Apoptosis inducer 24 exhibits antitumor efficacy in mice, without significant toxicity (LD₅₀ is 91.2 mg/kg) .

HY-161618

MJ04	JAK EGFR PI3K IGF-1R GSK-3	Inflammation/Immunology Endocrinology
MJ04 is a selective inhibitor for Janus Kinase 3 (JAK 3) with an *IC₅₀* of 2.03 nM. MJ04 inhibits T cell differentation and inhibits the proinfammatory cytokines in Lipopolysaccharides (HY-D1056)‑induced macrophages. MJ04 exhibits good pharmacokinetic characters in mice, promotes hair growth in DHT-induced androgenetic alopecia (AGA) in athymic mice model, without significant toxicity (LD₅₀ >2 g/kg) .

HY-N10653

Altemicidin (-)-Altemicidin	Others	Cancer
Altemicidin is a monoterpene alkaloid originally isolated from S. sioyaensis with acaricidal and anticancer activities. It is acaricidal to two-spotted spider mites (T. urticae) in a greenhouse pot test at concentrations of 10 and 100 ppm. Altemicidin inhibits the growth of murine L1210 lymphocytic leukemia and IMC carcinoma cells (IC₅₀s=0.84 and 0.82 μg/mL, respectively). It is toxic to mice with an LD₅₀ value of 0.3 mg/kg.

HY-162650

SL44	ClpP	Cancer
SL44 is an agonist for human caseinolytic protease P (HsClpP), with an *EC₅₀* of 1.30 μM. SL44 inhibits the proliferation of LM3 with an *IC₅₀* of 3.1 μM. SL44 induces apoptosis in HCC cells, through the degradation of respiratory chain complex subunits. SL44 exhibits antitumor efficacy in mouse models without obvious toxicity (LD₅₀=400 mg/kg). SL44 exhibits good pharmacokinetic characters in rat models .

HY-155997

Anti-inflammatory agent 56	COX	Inflammation/Immunology
Anti-inflammatory agent 56 (Compound 9) is a selective COX-2 inhibitor (IC₅₀: 0.54 μM). Anti-inflammatory agent 56 has anti-oxidant and anti-inflammatory effects. Anti-inflammatory agent 56 inhibits oxidative stress induced cell death. Anti-inflammatory agent 56 inhibits oxidative stress and neuroinflammation by inhibiting Keap1, COX-2 and iNOS. Anti-inflammatory agent 56 has low acute toxicity in mice (LD₅₀: 1000 mg/kg) .

HY-121874

EP009	JAK	Cancer
EP009 is a JAK3 inhibitor that selectively inhibits IL-2-mediated JAK3 tyrosine phosphorylation (IC50=10-20 μM in Kit225 cells) without affecting IL-3-induced JAK2 phosphorylation (up to 50 μM in BaF/3 cells). EP009 significantly reduced Kit225 cell viability (72 h, LD50=5.0 μM) while having no effect on BaF/3 cells. .

HY-151829

Fmoc-L-Asn(EDA-N3)-OH	ADC Linker	Others
Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-N6792

T-2 Toxin 1 Publications Verification T-2 Mycotoxin	Apoptosis DNA/RNA Synthesis	Metabolic Disease
T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains, *LD₅₀* values of T-2 Toxin in mice and rats are 5.2 and 1.5 mg/kg BW ^a,respectively . T-2 Toxin (T-2 Mycotoxin) can be transformed into a variety of metabolite, the typical metabolites of T-2 toxin in animals are HT-2 toxin and T-2-triol, which are hydrolysates . T-2 Toxin (T-2 Mycotoxin) is an inhibitor of protein synthesis resulting from binding peptidyltransferase, which is an integral part of the 60s ribosomal subunit. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides . T-2 Toxin (T-2 Mycotoxin) induces apoptosis in the immune system, gastrointestinal tissues, and fetal tissues .

HY-117019

LY150310 free base	Others	Cancer
LY150310 is able to inhibit thromboxane synthase, cyclooxygenase, and thrombin activation, biochemical processes that have been proposed in the literature as targets for anti-metastatic agents. The objectives of this study were twofold: (a) to compare the anti-metastatic activity of Eli Lilly compounds with reference anti-metastatic compounds nafazatrom and RA233; and (b) to examine the correlation between inhibition of spontaneous lung metastasis and survival. The anti-metastatic activity of the compounds was evaluated using the Lewis lung squamous cell carcinoma cell model. In this model, 5×10^5 tumor cells were implanted into the gastrocnemius muscle, the primary tumor was resected on day 14, and lung metastatic lesions were counted on day 25. The compounds were administered every 12 hours from day 5 to day 19. Nafazatrom, LY150310, LY189332, and LY135305 were found to inhibit spontaneous lung metastasis in a dose-dependent manner. The ED50 values ??of these compounds were 50, 0.5, 2, and 0.35 mg/kg/day, respectively; the corresponding therapeutic indices (LD50/ED50) were 7, 180, 255, and 511, respectively. To evaluate the effects of nafazatrom, LY150310, LY189332, and LY135305 on animal survival, these compounds were given at the maximum anti-metastatic dose of 200, 60, 20, and 6 mg/kg/day, respectively. Two dosing schedules were used: (a) from day 5 to 19; (b) from day 5 to death. These compounds did not significantly alter median survival times or the number of long-term survivors at any dosing schedule. RA233 did not inhibit lung metastasis or increase median survival time at a schedule in which the maximum tolerated dose of 200 mg/kg/day was given until death on day 5. Postmortem examination of animals given nafazatrom, LY150310, LY189332, and LY1350310 revealed complete suppression of lung lesions, whereas lesions developed in the liver, kidney, spleen, and brain. The results of this study suggest that the effects of a compound on the number of metastatic lesions in target organs may not be predictive of its effects on survival. To successfully translate laboratory data into clinical applications, survival should be considered a predictor of the potential clinical utility of a compound.

Cat. No.	Product Name	Type

HY-D1005A6

Poloxamer 124 (L44)

PEG-PPG-PEG, 2200 (Averag)

Co-solvents

Poloxamer 124 L44 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2200. Poloxamer 124 L44 reveals toxicity with an oral LD₅₀ of 5 g/kg in albino rats. Poloxamer 124 L44 causes ocular irritation. Poloxamer 124 L44 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .