Sudoterb (Synonyms: LL 3858)

Cat. No.: HY-14990 Purity: 98.38%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Sudoterb (LL 3858) is an orally active anti-Tuberculosis agent.

For research use only. We do not sell to patients.

Sudoterb Chemical Structure

CAS No. : 676266-31-2

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 126	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 126	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 330	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Other Forms of Sudoterb:

Sudoterb hydrochloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Sudoterb (LL 3858) is an orally active anti-Tuberculosis agent^[1].

In Vivo

Sudoterb (12.5 mg/kg and 25 mg/kg, p.o., 4 and 8 weeks) is effective against M.tuberculosis in mice^[2].
Sudoterb (p.o., mice) shows a LD₅₀ of 700 mg/kg^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

519.56

Formula

C₂₉H₂₈F₃N₅O

CAS No.

676266-31-2

Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=CC=NC=C1)NN2C(C)=C(CN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3)C=C2C5=CC=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (192.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9247 mL	9.6235 mL	19.2471 mL
5 mM	0.3849 mL	1.9247 mL	3.8494 mL
10 mM	0.1925 mL	0.9624 mL	1.9247 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.38%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (252 KB) HNMR (266 KB) LCMS (101 KB)

Handling Instructions (2659 KB)

References

[1]. Maha A. Elhakeem, et al. Synthesis and anti-mycobacterial evaluation of some new isonicotinylhydrazide analogues. Bulletin of Faculty of Pharmacy, Cairo University. 2015, 53 (1), 45-52

[2]. Protopopova M, et al. In search of new cures for tuberculosis. Med Chem. 2007 May;3(3):301-16. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9247 mL	9.6235 mL	19.2471 mL	48.1176 mL
	5 mM	0.3849 mL	1.9247 mL	3.8494 mL	9.6235 mL
	10 mM	0.1925 mL	0.9624 mL	1.9247 mL	4.8118 mL
	15 mM	0.1283 mL	0.6416 mL	1.2831 mL	3.2078 mL
	20 mM	0.0962 mL	0.4812 mL	0.9624 mL	2.4059 mL
	25 mM	0.0770 mL	0.3849 mL	0.7699 mL	1.9247 mL
	30 mM	0.0642 mL	0.3208 mL	0.6416 mL	1.6039 mL
	40 mM	0.0481 mL	0.2406 mL	0.4812 mL	1.2029 mL
	50 mM	0.0385 mL	0.1925 mL	0.3849 mL	0.9624 mL
	60 mM	0.0321 mL	0.1604 mL	0.3208 mL	0.8020 mL
	80 mM	0.0241 mL	0.1203 mL	0.2406 mL	0.6015 mL
	100 mM	0.0192 mL	0.0962 mL	0.1925 mL	0.4812 mL

Sudoterb Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sudoterb676266-31-2LL 3858LL3858LL-3858BacterialTuberculosisM.tuberculosisLD50Inhibitorinhibitorinhibit

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