2. Epigenetics PI3K/Akt/mTOR
  3. AMPK
  4. Chromium(III) acetate

Chromium(III) acetate  (Synonyms: Chromium acetate; Chromic acetate; Chromium triacetate)

Cat. No.: HY-D1163 Purity: ≥99.0%
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Chromium(III) acetate (Chromic acetate) is an AMPK inhibitor that promotes lipogenesis by inhibiting AMPK phosphorylation. Chromium(III) acetate has low toxicity in mammals, with an LD50 of 2365 mg/kg in rats.

For research use only. We do not sell to patients.

Chromium(III) acetate Chemical Structure

Chromium(III) acetate Chemical Structure

CAS No. : 1066-30-4

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Chromium(III) acetate Related Antibodies

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1 Publications Citing Use of MCE Chromium(III) acetate

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

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Description

Chromium(III) acetate (Chromic acetate) is an AMPK inhibitor that promotes lipogenesis by inhibiting AMPK phosphorylation. Chromium(III) acetate has low toxicity in mammals, with an LD50 of 2365 mg/kg in rats[1][2].

In Vitro

Chromium(III) acetate (0.1-10 μM，96 h) stimulates adipogenesis through regulation of gene expression and phosphorylation of adenosine monophosphate-activated protein kinase in bovine intramuscular or subcutaneous adipocytes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chromium(III) acetate Related Antibodies

Western Blot Analysis[2]

Cell Line: Bovine intramuscular(IM) preadipocytes, Bovine subcutaneous(SC) preadipocytes
Concentration: 0.1, 1, 10 μM
Incubation Time: 96 h
Result: Reduced the ratio of phosphorylated AMPKα to AMPKα.

Real Time qPCR[2]

Cell Line: Bovine intramuscular(IM) preadipocytes, Bovine subcutaneous(SC) preadipocytes
Concentration: 0.1, 1, 10 μM
Incubation Time: 96 h
Result: Upregulate the mRNA levels of adipogenic transcription factors C/EBPβ, PPARγ, and SCD in bovine IM adipocytes (10 μM).
Downregulates AMPKα gene expression and upregulates C/EBPβ and SCD gene expression (10 μM) in bovine SC adipocytes.
Molecular Weight

229.13

Formula

C6H9CrO6
CAS No.
Appearance

Solid

Color

Light green to green

SMILES

C[Cr](C)C.O=C=O.O=C=O.O=C=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (62.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3643 mL 21.8217 mL 43.6433 mL
5 mM 0.8729 mL 4.3643 mL 8.7287 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.43 mg/mL (6.24 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.43 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (14.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1.43 mg/mL (6.24 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.43 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (14.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥99.0%

SDS (419 KB)

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3643 mL 21.8217 mL 43.6433 mL 109.1084 mL
5 mM 0.8729 mL 4.3643 mL 8.7287 mL 21.8217 mL
10 mM 0.4364 mL 2.1822 mL 4.3643 mL 10.9108 mL
15 mM 0.2910 mL 1.4548 mL 2.9096 mL 7.2739 mL
20 mM 0.2182 mL 1.0911 mL 2.1822 mL 5.4554 mL
25 mM 0.1746 mL 0.8729 mL 1.7457 mL 4.3643 mL
30 mM 0.1455 mL 0.7274 mL 1.4548 mL 3.6369 mL
40 mM 0.1091 mL 0.5455 mL 1.0911 mL 2.7277 mL
50 mM 0.0873 mL 0.4364 mL 0.8729 mL 2.1822 mL
60 mM 0.0727 mL 0.3637 mL 0.7274 mL 1.8185 mL
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Chromium(III) acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chromium(III)1066-30-4ChromiumChromic Chromium triacetateAMPKAMP-activated protein kinaseBovine intramuscular(IM) preadipocytesBovine subcutaneous(SC) preadipocytesMetabolic DiseaseInhibitorinhibitorinhibit

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