2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling PI3K/Akt/mTOR
  3. JAK EGFR PI3K IGF-1R GSK-3
  4. MJ04

MJ04 is a selective inhibitor for Janus Kinase 3 (JAK 3) with an IC50 of 2.03 nM. MJ04 inhibits T cell differentation and inhibits the proinfammatory cytokines in Lipopolysaccharides (HY-D1056)‑induced macrophages. MJ04 exhibits good pharmacokinetic characters in mice, promotes hair growth in DHT-induced androgenetic alopecia (AGA) in athymic mice model, without significant toxicity (LD50 >2 g/kg).

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MJ04 Chemical Structure

MJ04 Chemical Structure

CAS No. : 2099014-23-8

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MJ04 Related Antibodies

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GSK-3 GSK-3α GSK-3β

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Description

MJ04 is a selective inhibitor for Janus Kinase 3 (JAK 3) with an IC50 of 2.03 nM. MJ04 inhibits T cell differentation and inhibits the proinfammatory cytokines in Lipopolysaccharides (HY-D1056)‑induced macrophages. MJ04 exhibits good pharmacokinetic characters in mice, promotes hair growth in DHT-induced androgenetic alopecia (AGA) in athymic mice model, without significant toxicity (LD50 >2 g/kg)[1].

IC50 & Target

JAK3

2.03 nM (IC50)

JAK1

192.64 nM (IC50)

JAK2

255.88 nM (IC50)

GSK-3β

1843 nM (IC50)

EGFR

3267 nM (IC50)

PI3Kγ

3667 nM (IC50)

Molecular Weight

345.37

Formula

C20H16FN5
CAS No.
SMILES

FC1=CC=C(C2=CN=C(NC=C3C4=NC(NC5CC5)=NC=C4)C3=C2)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MJ04 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MJ042099014-23-8MJ 04MJ-04JAKEGFRPI3KIGF-1RGSK-3Janus kinaseEpidermal growth factor receptorErbB-1HER1Phosphoinositide 3-kinaseInsulin-like growth factor-1 receptorGlycogen synthase kinase-3Glycogen synthase kinase 3C57BL/6 mouseWistar ratHEK293A549HCT-116PC-3MCF-7Mia PaCa-2lung cancercolon carcinoma cellprostate carcinomabreast cancerpancreatic cancerInhibitorinhibitorinhibit

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