2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. EGFR kinase inhibitor 5

EGFR kinase inhibitor 5 (Compound 4c) is an orally active inhibitor for epidermal growth factor receptor (EGFR) kinase, with IC50 of 18.35 μM. EGFR kinase inhibitor 5 induces apoptosis. EGFR kinase inhibitor 5 exhibits anticancer and anti-inflammatory activity with low toxicity (LD50 range: 500-2000 mg/kg).

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EGFR kinase inhibitor 5 Chemical Structure

EGFR kinase inhibitor 5 Chemical Structure

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EGFR kinase inhibitor 5 Related Antibodies

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Description

EGFR kinase inhibitor 5 (Compound 4c) is an orally active inhibitor for epidermal growth factor receptor (EGFR) kinase, with IC50 of 18.35 μM. EGFR kinase inhibitor 5 induces apoptosis. EGFR kinase inhibitor 5 exhibits anticancer and anti-inflammatory activity with low toxicity (LD50 range: 500-2000 mg/kg)[1].

IC50 & Target

IC50: 18.35 μM (EGFR Kinase)
In Vitro

EGFR kinase inhibitor 5 (0-80 μM, 72 h) inhibits migration of cancer cell A549, and exhibits anticancer activity against cancer cell A549, MCF7 and HCT116, with IC50s of 10.74, 18.73 and 23.22 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR kinase inhibitor 5 Related Antibodies

Cell Migration Assay [1]

Cell Line: A549
Concentration: 0-30 μM
Incubation Time: 24 h
Result: Inhibited cell migration.
In Vivo

EGFR kinase inhibitor 5 (14.77 mg/kg, p.o., 15 days) exhibits anti-inflammatory efficacy in carrageenan induced rat paw edema model, with low ulcerogenic potential and lipid peroxidation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Carrageenan-induced hind paw edema in Wistar rats model[1]
Dosage: 0.0314 mmol/kg
Administration: p.o., 15 days
Result: Inhibited 80.17% paw edema.
Molecular Weight

470.41

Formula

C21H16BrN3OS2
SMILES

O=C1C(C)SC(C2=C(C3=CC=CC=C3)N=C4N2C=CS4)N1C5=CC=C(Br)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR kinase inhibitor 5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR kinase inhibitor 5EGFR kinase inhibitor5EGFR kinase inhibitor-5EGFRApoptosisEpidermal growth factor receptorErbB-1HER1HCT116A549MCF-7Wistar ratsInhibitorinhibitorinhibit

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EGFR kinase inhibitor 5
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HY-162482
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