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Results for "

NMB

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibody-Drug Conjugates (ADCs) (1) Bombesin Receptor (3) Endogenous Metabolite (1) Microtubule/Tubulin (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (3)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116216

PD 168368	Bombesin Receptor	Cancer
PD 168368 is a potent, competitive, and selective neuromedin B receptor (NMB-R) antagonist with the K_i of 15–45 nM . PD 168368 is neuromedin B receptor (NMBR; IC₅₀=96 nM) / gastrin-releasing peptide receptor (GRPR IC₅₀=3500 nM) antagonist . PD 168368 also is a mixed FPR1/FPR2/FPR3 agonist with EC₅₀s of 0.57, 0.24, and 2.7 nM, respectively .

HY-P0241

Neuromedin B 1 Publications Verification	Endogenous Metabolite	Neurological Disease
Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.

HY-141604

Glembatumumab vedotin CDX-011; CR011-vcMMAE	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Glembatumumab vedotin (CDX-011) is an ADC (antibody-drug conjugates (ADCs)) comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin has potent anticancer effects .

HY-103277A

BIM 23042 TFA	Bombesin Receptor	Neurological Disease Metabolic Disease
BIM 23042 TFA, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca ²⁺ release .

HY-RS09368

NMB Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NMB Human Pre-designed siRNA Set A contains three designed siRNAs for NMB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NMB Human Pre-designed siRNA Set A NMB Human Pre-designed siRNA Set A

HY-103277

BIM 23042	Bombesin Receptor	Neurological Disease Metabolic Disease
BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca ²⁺ release .

Cat. No.	Product Name	Target	Research Area

HY-P0241

Neuromedin B 1 Publications Verification	Endogenous Metabolite	Neurological Disease
Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.

HY-103277A

BIM 23042 TFA	Bombesin Receptor	Neurological Disease Metabolic Disease
BIM 23042 TFA, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca ²⁺ release .

HY-P5163

NMB-1	Peptides	Inflammation/Immunology
NMB-1 is a conopeptide analogue. NMB-1 selectively inhibits sustained mechanically activated currents in sensory neurons (IC₅₀: 1 μM). NMB-1 inhibits mechanical pain. NMB-1 can be used for research of hearing and pressure-evoked pain .

HY-103277

BIM 23042	Bombesin Receptor	Neurological Disease Metabolic Disease
BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca ²⁺ release .

Neuromedin B 1 Publications Verification	Structural Classification Natural Products Animals Source classification Endogenous metabolite	Endogenous Metabolite
Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.

Species:	Human (3) Mouse (1)
Tag:	His (3) Fc (1)
Source:	HEK293 (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P77116

	GPNMB/Osteoactivin Protein, Mouse (HEK293, His) Transmembrane Glycoprotein NMB; GPNMB; HGFIN; NMB	Mouse	HEK293
	GPNMB/bone active protein shows promise as a melanogenic enzyme, possibly involved in melanin synthesis. Its regulatory influence on melanin production highlights its critical role in pigment formation. GPNMB/Osteoactivin Protein, Mouse (HEK293, His) is the recombinant mouse-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-His labeled tag. The total length of GPNMB/Osteoactivin Protein, Mouse (HEK293, His) is 480 a.a., with molecular weight of ~96 kDa.

HY-P75951

	GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, Fc) Transmembrane Glycoprotein NMB; GPNMB; HGFIN; NMB	Human	HEK293
	GPNMB, also known as Osteoactivin, is suggested to potentially function as a melanogenic enzyme. GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, Fc) is the recombinant human-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, Fc) is 453 a.a., with molecular weight of ~107.5 kDa.

HY-P70836

	GPNMB/Osteoactivin Protein, Human (HEK293, His) Transmembrane Glycoprotein NMB; Transmembrane Glycoprotein HGFIN; GPNMB; HGFIN; NMB	Human	HEK293
	GPNMB, also known as osteoactivin, is a protein thought to have a potential role as a melanin-producing enzyme. Melanogenic enzymes are involved in the production of melanin, the pigment that determines skin, hair and eye color. GPNMB/Osteoactivin Protein, Human (HEK293, His) is the recombinant human-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P75950

	GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, His) Transmembrane Glycoprotein NMB; GPNMB; HGFIN; NMB	Human	HEK293
	GPNMB, also known as Osteoactivin, is suggested to potentially function as a melanogenic enzyme. GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, His) is the recombinant human-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-His labeled tag. The total length of GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, His) is 453 a.a., with molecular weight of 85-90 kDa.

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HY-P81414

	GPNMB Antibody (YA1159) NMB; HGFIN	IHC-P	Human
	GPNMB Antibody (YA1159) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1159), targeting GPNMB. GPNMB Antibody (YA1159) can be used for IHC-P experiment in human background.

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Cat. No.	Product Name		Classification

HY-RS09368

NMB Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
NMB Human Pre-designed siRNA Set A contains three designed siRNAs for NMB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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NMB

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