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antifungal effect

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46

Inhibitors & Agonists

1

Biochemical Assay Reagents

1

Peptides

16

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0709
    Coumarin

    		Bacterial Fungal Infection Neurological Disease Inflammation/Immunology Cancer
    Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity .
    Coumarin
  • HY-143406
    Antifungal agent 25

    		Fungal Infection
    Antifungal agent 25 is a potent broad-spectrum antifungal agent. Antifungal agent 25 shows antifungal effect against Candida albicans and fluconazole-resistant strain of Candida albicans. Antifungal agent 25 stable metabolic property in vivo .
    Antifungal agent 25
  • HY-151440
    Antifungal agent 42

    		Fungal Infection
    Antifungal agent 42 is an antifungal agent. Antifungal agent 42 has an inhibitory effect on lanosterol 14α-demethylase (CYP51) of C.alb.. Antifungal agent 42 inhibits biofilm formation .
    Antifungal agent 42
  • HY-151439
    Antifungal agent 41

    		Fungal Infection
    Antifungal agent 41 (compound B01) is an antifungal agent. Antifungal agent 41 shows inhibitory effect on Candida albicans in virto and vivo. Antifungal agent 41 can be used for the research of invasive fungal infections .
    Antifungal agent 41
  • HY-151437
    Antifungal agent 40

    		Fungal Infection
    Antifungal agent 40 is an antifungal agent which extends into the narrow hydrophobic pocket II of C.alb. CYP51. Antifungal agent 40 has an inhibitory effect on lanosterol 14α-demethylase (CYP51). Antifungal agent 40 inhibits biofilm formation .
    Antifungal agent 40
  • HY-N9370
    Isobellidifolin

    		Fungal Infection
    Isobellidifolin, a xanthone, is a free radical scavenger and antioxidant compound. Isobellidifolin has potent antifungal effect .
    Isobellidifolin
  • HY-N10971
    Noraucuparin

    		Fungal Infection
    Noraucuparin is a biphenyl-type phytoalexin. Noraucuparin has antifungal effect. Noraucuparin can be isolated from the leaves of Sorbus pohuashanensis .
    Noraucuparin
  • HY-106333
    Irtemazole

    R 60844

    		 Fungal Infection Inflammation/Immunology
    Irtemazole is an orally active antifungal agent. Irtemazole possesses uricosuric effect. Irtemazole is used in the research for blastomycosis, histoplasmosis, and aspergillosis .
    Irtemazole
  • HY-139900
    Benzyl 2-hydroxy-6-methoxybenzoate

    		Fungal Infection
    Benzyl 2-hydroxy-6-methoxybenzoate shows the strongest antifungal effect, with IC50 of 25–26 μg/mL for both fungal strains.
    Benzyl 2-hydroxy-6-methoxybenzoate
  • HY-N1289
    Sequosempervirin B

    		Fungal Phosphodiesterase (PDE) Infection
    Sequosempervirin B, a norlignan isolated from the branches and leaves of Sequoia sempervirens, has antifungal properties. Sequosempervirin B has an inhibitory effect on cyclic AMP phosphodiesterase .
    Sequosempervirin B
  • HY-B2012
    Flusilazole

    DPX-H6573

    		 Fungal Infection
    Flusilazole (DPX-H6573), an organosilane fungicide, has broad-spectrum antifungal effect. Flusilazole exhibits curative and preventative activities and is recommended for use in agriculture and horticulture .
    Flusilazole
  • HY-W097994
    DHMB

    2,3-Dihydroxy-4-methoxybenzaldehyde

    		 Fungal Infection Inflammation/Immunology
    DHMB (2,3-Dihydroxy-4-methoxybenzaldehyde) is a small organic molecule with anti-fungal and anti-inflammatory activity. DHMB has protective effect on intestinal epithelial cells .
    DHMB
  • HY-23155
    2-Phenylethyl isothiocyanate

    2-PE ITC

    		 Fungal Infection
    2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternata might be via reduction in toxin content and breakdown of cell membrane integrity .
    2-Phenylethyl isothiocyanate
  • HY-126237
    Acetyllovastatin

    		Fungal Infection
    Acetyllovastatin, a acetate of Lovastatin, presentes a moderate inhibitory effect against the enzyme acetylcholinesterase with an IC50 of 79 μg/mL. Lovastatin has been found to display antifungal activity, and suppresses proliferation of a number of transformed cell lines .
    Acetyllovastatin
  • HY-N11528
    Eugenitol

    7-Noreugenitin

    		 Others Infection
    Eugenitol (Compound 3) is an antifungal metabolite isolated and purified from Diaporthe eucalyptorum. Eugenitol has inhibitory effect on four plant pathogenic fungi (Alternaria solani, Botrytis cinerea, Fusarium solani and Gibberella saubinettii) .
    Eugenitol
  • HY-122955
    Xanthobaccin A

    		Fungal Infection
    Xanthobaccin A is an antifungal compound, can be isolated from the culture fluid of Stenotrophomonas sp. strain SB-K88. Xanthobaccin A has potent inhibitory effect on sugar beet damping-off disease .
    Xanthobaccin A
  • HY-N0709R
    Coumarin (Standard)

    		Bacterial Fungal Infection Neurological Disease Inflammation/Immunology Cancer
    Coumarin (Standard) is the analytical standard of Coumarin. This product is intended for research and analytical applications. Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity .
    Coumarin (Standard)
  • HY-B2012R
    Flusilazole (Standard)

    		Fungal Infection
    Flusilazole (Standard) is the analytical standard of Flusilazole. This product is intended for research and analytical applications. Flusilazole (DPX-H6573), an organosilane fungicide, has broad-spectrum antifungal effect. Flusilazole exhibits curative and preventative activities and is recommended for use in agriculture and horticulture .
    Flusilazole (Standard)
  • HY-N10786
    1,3,6-Trihydroxy-5-methoxyxanthone

    		Fungal Infection
    1,3,6-Trihydroxy-5-methoxyxanthone is a nature product that could be isolated form the root bark of Tovomita krukovii. 1,3,6-Trihydroxy-5-methoxyxanthone has anti-fungal effect .
    1,3,6-Trihydroxy-5-methoxyxanthone
  • HY-W015551S
    trans-2-Decenal-d2

    (E)-Dec-2-enal-d2

    		 Biochemical Assay Reagents Isotope-Labeled Compounds Others
    trans-2-Decenal-d2 is deuterated labeled Coumarin (HY-N0709). Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity .
    trans-2-Decenal-d2
  • HY-N6780
    Ophiobolin B

    		Fungal Infection
    Ophiobolin B, a sesterterpene metabolite of Helminthosporium oryzae, inhibits proton extrusion from maize coleoptiles. Ophiobolin B inhibits fusicoccin (FC) promoted proton extrusion, potassium uptake and cell enlargement . The MIC values with the antifungal effect of Ophiobolins B on different zygomycetes is 25–50 μg/mL .
    Ophiobolin B
  • HY-N8015
    Octanal

    		Endogenous Metabolite Bacterial Fungal Infection Cancer
    Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC50 value of 3.5 μg/mL .
    Octanal
  • HY-143899
    FBA-IN-1

    		Fungal Infection
    FBA-IN-1 (compound 2a11) is a first-in-class, covalent and allosteric inhibitor of fructose-1,6-bisphosphate aldolase from Candida albicans (CaFBA). FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with the MIC80 of 1 μg/mL .
    FBA-IN-1
  • HY-17643
    Oteseconazole
    1 Publications Verification

    VT-1161

    		 Fungal Cytochrome P450 Infection
    Oteseconazole (VT-1161) is a potent and orally active anti-fungal agent. Oteseconazole potently binds to and inhibits Candida albicans cytochrome P45051 (CYP51) activity (Kd ≤39 nM), shows no obvious effect on human CYP51. Oteseconazole also can be used for the research of dermatophytes .
    Oteseconazole
  • HY-N6635
    trans-Nerolidol

    		Fungal Infection Cancer
    trans-Nerolidol is a sesquiterpene alcohol. It can be isolated from f aerial parts of Warionia saharae ex Benth. trans-Nerolidol improves the anti-proliferative effect of Doxorubicin (HY-15142A) against intestinal cancer cells in vitro. trans-Nerolidol also has anti-fungal activity .
    trans-Nerolidol
  • HY-23155S
    2-Phenylethyl isothiocyanate-d5

    2-PE ITC-d5

    		 Fungal Infection
    2-Phenylethyl isothiocyanate-d5 isothiocyanate-d5 is the deuterium labeled 2-Phenylethyl isothiocyanate[1]. 2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternata might be via reduction in toxin content and breakdown of cell membrane integrity[2][3].
    2-Phenylethyl isothiocyanate-d5
  • HY-B0450
    Ciclopirox
    Maximum Cited Publications
    6 Publications Verification

    HOE296b

    		 Fungal Bacterial Ferroptosis Autophagy Infection Inflammation/Immunology Cancer
    Ciclopirox (HOE296b) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox also has anticancer and anti-inflammatory effect .
    Ciclopirox
  • HY-B0450A
    Ciclopirox olamine
    Maximum Cited Publications
    6 Publications Verification

    Ciclopirox ethanolamine; HOE 296

    		 Fungal Bacterial Ferroptosis Infection Cancer
    Ciclopirox olamine (Ciclopirox ethanolamine) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox olamine also has anticancer and anti-inflammatory effect .
    Ciclopirox olamine
  • HY-159585
    CYP51-IN-20

    		Cytochrome P450 Fungal Infection
    CYP51-IN-20 (compound 5b) is an inhibitor of CYP51 and has antifungal activity. CYP51-IN-20 has a significant inhibitory effect on Candida albicans ATCC 10231, downregulates ERG11 (Cyp51) gene expression, and significantly reduces the yeast-to-hyphae morphological transition. CYP51-IN-20 can synergize with Voriconazole (HY-76200) to occupy the entire CYP51 binding site and exert a synergistic inhibitory effect in the Glechoma moth model .
    CYP51-IN-20
  • HY-124701
    Filastatin

    		Fungal Infection
    Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect .
    Filastatin
  • HY-B0736A
    Sertaconazole nitrate
    2 Publications Verification

    FI7056

    		 Fungal Autophagy Apoptosis p38 MAPK Microtubule/Tubulin Infection Cancer
    Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells .
    Sertaconazole nitrate
  • HY-B0736
    Sertaconazole

    FI7056 free base

    		 Fungal Autophagy Apoptosis p38 MAPK Microtubule/Tubulin Infection Inflammation/Immunology Cancer
    Sertaconazole (FI7056 free base) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells .
    Sertaconazole
  • HY-17643R
    Oteseconazole (Standard)

    		Fungal Cytochrome P450 Infection
    Oteseconazole (Standard) is the analytical standard of Oteseconazole. This product is intended for research and analytical applications. Oteseconazole (VT-1161) is a potent and orally active anti-fungal agent. Oteseconazole potently binds to and inhibits Candida albicans cytochrome P45051 (CYP51) activity (Kd ≤39 nM), shows no obvious effect on human CYP51. Oteseconazole also can be used for the research of dermatophytes .
    Oteseconazole (Standard)
  • HY-N8015R
    Octanal (Standard)

    		Endogenous Metabolite Bacterial Fungal Infection Cancer
    Octanal (Standard) is the analytical standard of Octanal. This product is intended for research and analytical applications. Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC50 value of 3.5 μg/mL .
    Octanal (Standard)
  • HY-N6693
    Valinomycin
    4 Publications Verification

    NSC 122023

    		 Apoptosis Antibiotic Autophagy Fungal Infection Others Cancer
    Valinomycin is a potassium-specific ionophore, the valinomycin-K + complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K + gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .
    Valinomycin
  • HY-N6635R
    trans-Nerolidol (Standard)

    		Fungal Infection Cancer
    trans-Nerolidol (Standard) is the analytical standard of trans-Nerolidol. This product is intended for research and analytical applications. trans-Nerolidol is a sesquiterpene alcohol. It can be isolated from f aerial parts of Warionia saharae ex Benth. trans-Nerolidol improves the anti-proliferative effect of Doxorubicin (HY-15142A) against intestinal cancer cells in vitro. trans-Nerolidol also has anti-fungal activity .
    trans-Nerolidol (Standard)
  • HY-162488
    Laccase-IN-3

    		Fungal Infection
    Laccase-IN-3 (Compound 2b) is a laccase inhibitor (IC50 = 1.02= μM) with significant antifungal activity. Laccase-IN-3 shows superior inhibitory effect on Botryosphaeria dothidea (EC50 = 0.17 mg/L). Laccase-IN-3 effectively blocks the catalytic function of laccase by binding to its active center. Laccase-IN-3 also disrupts pathogen cell membrane integrity and increases ROS .
    Laccase-IN-3
  • HY-B0450R
    Ciclopirox (Standard)

    		Fungal Bacterial Ferroptosis Autophagy Infection Inflammation/Immunology Cancer
    Ciclopirox (Standard) is the analytical standard of Ciclopirox. This product is intended for research and analytical applications. Ciclopirox (HOE296b) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox also has anticancer and anti-inflammatory effect .
    Ciclopirox (Standard)
  • HY-B0450AR
    Ciclopirox (olamine) (Standard)

    		Fungal Bacterial Ferroptosis Infection Cancer
    Ciclopirox (olamine) (Standard) is the analytical standard of Ciclopirox (olamine). This product is intended for research and analytical applications. Ciclopirox olamine (Ciclopirox ethanolamine) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox olamine also has anticancer and anti-inflammatory effect .
    Ciclopirox (olamine) (Standard)
  • HY-N7135
    Tropolone

    		Tyrosinase Fungal Metabolic Disease Inflammation/Immunology Cancer
    Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU 2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma .
    Tropolone
  • HY-143236
    DHFR-IN-1

    		Bacterial Fungal Infection
    DHFR-IN-1 (compound 12) is a potent and selective DHFR (dihydrofolate reductase)inhibitor, with an IC50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin (HY-B0330), where the FIC (fractional inhibitory concentration index) value is 0.249 .
    DHFR-IN-1
  • HY-B1324A
    Oxiconazole

    Ro 13-8996 free base

    		 Fungal Cytochrome P450 Antibiotic Infection Cancer
    Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
    Oxiconazole
  • HY-N7236
    Pervicoside B

    		Parasite Fungal Infection
    Pervicoside B is a glycoside C isolated from Neothyone gibbosa sea cucumber. In vitro studies have shown that Pervicoside B has a potent antiparasitic effect against Leishmania mexicana, inhibiting 100% of promastigotes at 5-10 μg/mL. Pervicoside B also exhibits strong antifungal activity against Aspergillus niger, with MIC values ranging from 4.65 to 16.7 μg/mL. Pervicoside B has potential applications in the inhibition of parasitic infections and fungal diseases .
    Pervicoside B
  • HY-B0736AR
    Sertaconazole (nitrate) (Standard)

    		Fungal Autophagy Apoptosis p38 MAPK Microtubule/Tubulin Infection
    Sertaconazole (nitrate) (Standard) is the analytical standard of Sertaconazole (nitrate). This product is intended for research and analytical applications. Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells .
    Sertaconazole (nitrate) (Standard)
  • HY-B1324
    Oxiconazole nitrate
    1 Publications Verification

    Ro 13-8996

    		 Fungal Cytochrome P450 Antibiotic Infection Cancer
    Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
    Oxiconazole nitrate
  • HY-B1324R
    Oxiconazole nitrate (Standard)

    		Fungal Cytochrome P450 Antibiotic Infection Cancer
    Oxiconazole nitrate (Standard) is the analytical standard of Oxiconazole nitrate. This product is intended for research and analytical applications. Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
    Oxiconazole nitrate (Standard)

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