Laccase-IN-3 

Laccase-IN-3 (Compound 2b) is a laccase inhibitor (IC₅₀ = 1.02= μM) with significant antifungal activity. Laccase-IN-3 shows superior inhibitory effect on Botryosphaeria dothidea (EC₅₀ = 0.17 mg/L). Laccase-IN-3 effectively blocks the catalytic function of laccase by binding to its active center. Laccase-IN-3 also disrupts pathogen cell membrane integrity and increases ROS^[1].

Laccase-IN-3 (25 mg/L) inhibitis the fungal activity by is 98.2% (B. dothidea), 92% (S. sclerotiorum), 93.9 % (F. graminearum), 53.1 % (B. cinerea), 59.9 % (P. capsici), 22.0 % (P. infestans), 81.5 % (P. nicotianae), respectively^[1].
Laccase-IN-3 shows ECsub>50 against various fungi: 0.17 mg/L (B. dothidea), 2.55 mg/L (S. sclerotiorum), 2.03 mg/L (F. graminearum)^[1].
Laccase-IN-3 (0.79-6.25 mg/L;) inhibits fungal growth by disrupting the morphology of B. dothidea^[1].
Laccase-IN-3 (10-25 mg/L; 120min) disrupts cell membrane integrity and increases cell membrane permeability of B. dothidea mycelia. Laccase-IN-3 reduces the extracellular pH and destabilizes the intracellular environment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Laccase-IN-3 (100,200 mg/L; 6days) shows significant protective (92.6% and 86.8%) and therapeutic (85.0% and 78.9%) activity gainst apple infected with B. dothidea, better than Boscalid (HY-119976)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

246.28

C₁₄H₁₅FN₂O

O=C([C@H]1[C@H](C2)C=C[C@H]2C1)NNC3=CC=C(F)C=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jin DJ, et al. Design, synthesis, antifungal evaluation and mechanism study of novel norbornene derivatives as potential laccase inhibitors. Pest Manag Sci. 2024 Apr 16.  [Content Brief]