2. Anti-infection
  3. Fungal
  4. Antifungal agent 40

Antifungal agent 40 is an antifungal agent which extends into the narrow hydrophobic pocket II of C.alb. CYP51. Antifungal agent 40 has an inhibitory effect on lanosterol 14α-demethylase (CYP51). Antifungal agent 40 inhibits biofilm formation.

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Antifungal agent 40 Chemical Structure

Antifungal agent 40 Chemical Structure

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Antifungal agent 40 Related Antibodies

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Description

Antifungal agent 40 is an antifungal agent which extends into the narrow hydrophobic pocket II of C.alb. CYP51. Antifungal agent 40 has an inhibitory effect on lanosterol 14α-demethylase (CYP51). Antifungal agent 40 inhibits biofilm formation[1].

IC50 & Target

CYP51[1]
In Vitro

Antifungal agent 40 (compound A03, 0.25-128 μg/mL) inhibits fungal activity with MIC values of 1-64 μg/mL[1].
Antifungal agent 40 (1-8 μg/mL, 16 h) inhibits lanosterol 14α-demethylase (CYP51) of C.alb (GC-MS analysis)[1].
Antifungal agent 40 (0.5 μg/mL, 1.5-24 h) displays antibiofilm activity against FCZ-Resistant C.alb[1].
Antifungal agent 40 (0-10 μM respectively) shows cytotoxicity against HL-60, MDA-MB-231 and PC-3 cells with IC50 values of 5.18, 3.25, 0.98 μM respectively[1].
Antifungal agent 40 (2-32 μg/mL, 3 h) displays high hemolysis rate in rabbit erythrocyte[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antifungal agent 40 Related Antibodies
Molecular Weight

490.29

Formula

C22H20Cl2N4Se
SMILES

ClC1=CC=C(C([Se]C(C2=CC=C(Cl)C=C2)CN3C=CN=C3)CN4C=CN=C4)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antifungal agent 40 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antifungal agent 40Antifungal agent40Antifungal agent-40FungalAntifungalinfectionbiofilmC.albhemolysiserythrocyteInhibitorinhibitorinhibit

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