Oxiconazole (Synonyms: Ro 13-8996 free base)

Name: Oxiconazole
Brand: MedChemExpress
SKU: HY-B1324A

Cat. No.: HY-B1324A: FAQs
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Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest.

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Oxiconazole Chemical Structure

CAS No. : 64211-45-6

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Other In-stock Forms of Oxiconazole:

Oxiconazole nitrate

Other Forms of Oxiconazole:

Oxiconazole nitrate In-stock

1 Publications Citing Use of MCE Oxiconazole

•Int J Biol Sci. 2022; 18(9):3747-3761.

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[2]

CYP3A4

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	EC₅₀	13.5 μM Compound: Oxiconazole	Inhibition of LPS induced NO production in mouse BV-2 cells by Griess reagent based analysis Inhibition of LPS induced NO production in mouse BV-2 cells by Griess reagent based analysis	[PMID: 34875520]

In Vitro

Oxiconazole (24 h; 0-40 μM) inhibits CRC cell growth^[3].
Oxiconazole has antifungal activity against Candida, Aspergillus and Trichophyton^[1].
Antifungal Activities of Oxiconazole^[1].

	Candida albicans	Candida glabrata	Candida parapsilosis	Aspergillus fumigatus	Aspergillus flavus	Trichophyton mentagrophytes	Trichophyton rubrum
Oxiconazole	0.03 μg/mL	0.01 μg/mL	0.008 μg/mL	2 μg/mL	2 μg/mL	2 μg/mL	2 μg/mL

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[3]

Cell Line:	HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460
Concentration:	0-40 μM
Incubation Time:	24 h
Result:	Exhibited inhibitory activity against HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460 with IC₅₀s of 25.86 μM, 27.34 μM, 21.01 μM, 25.56 μM, 21.75 μM, 24.87 μM and 126.4 μM.

In Vivo

Oxiconazole (50 mg/kg/day; IP; for 12 days) significantly restrains CRC cell growth^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c nude mice (injected subcutaneously with HCT116 cells (1×10⁷/mouse)^[3]
Dosage:	50 mg/kg/day
Administration:	IP; for 12 days
Result:	Significantly restrained CRC cell growth and showed no obvious side effects.

Clinical Trial

Molecular Weight

429.13

Formula

C₁₈H₁₃Cl₄N₃O

CAS No.

64211-45-6

SMILES

ClC1=CC=C(/C(CN2C=CN=C2)=N/OCC3=CC=C(Cl)C=C3Cl)C(Cl)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rossello A, et al. Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. J Med Chem. 2002 Oct 24;45(22):4903-12. [Content Brief]

[2]. Svecova L, et al. Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression. Drug Metab Dispos. 2008 Feb;36(2):339-48. [Content Brief]

[3]. Shi J, et al. Repurposing Oxiconazole against Colorectal Cancer via PRDX2-mediated Autophagy Arrest. Int J Biol Sci. 2022 May 21;18(9):3747-3761. [Content Brief]

Oxiconazole Related Classifications

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxiconazole64211-45-6Ro 13-8996FungalCytochrome P450AntibioticCYPsAntifungalCYP3A4Rifampicincolorectal cancerPRDX2HCT116BALB/c nude miceInhibitorinhibitorinhibit

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