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Pathways Recommended:	Vitamin D Related/Nuclear Receptor

Results for "

gasdermin D

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AIM2 (1) Aldehyde Dehydrogenase (ALDH) (2) Apoptosis (3) Autophagy (1) Caspase (1) Cuproptosis (2) Deubiquitinase (1) IKK (1) Interleukin Related (2) NF-κB (1) NOD-like Receptor (NLR) (3) P2Y Receptor (1) Pyroptosis (4)
By Research Areas:	Cancer (3) Inflammation/Immunology (7) Metabolic Disease (2)

Inhibitors & Agonists

Screening Libraries

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111674

LDC7559 5+ Cited Publications	Pyroptosis	Inflammation/Immunology
LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages .

HY-111675

Ac-FLTD-CMK 5 Publications Verification	Caspase Pyroptosis	Inflammation/Immunology
Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC₅₀ of 46.7 nM), caspases-4 (IC₅₀ of 1.49 μM), caspases-5 (IC₅₀ of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3 .

HY-B0240

Disulfiram 60+ Cited Publications Tetraethylthiuram disulfide; TETD	Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis	Metabolic Disease Cancer
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu ²⁺ increases intracellular ROS levels and induces cuproptosis .

HY-152670

JC2-11 1 Publications Verification	NOD-like Receptor (NLR) AIM2	Inflammation/Immunology
JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1 .

HY-155194

P2X7 receptor antagonist-4	Others	Inflammation/Immunology
P2X7 receptor antagonist-4 (Compound 14a) is a P2X7R antagonist. The P2X7 receptor antagonist-4 values of P2X7R IC₅₀ in human and mouse are 64.7 and 10.1 nM, respectively. P2X7 receptor antagonist-4 can inhibit the activation of NLRP3 inflammasome, thereby inhibiting the expression of caspase-1, gasdermin D, IL-1β and IL-18 in the damaged kidney of sepsis mice .

HY-13453

BAY 11-7082 Maximum Cited Publications 299 Publications Verification BAY 11-7821	IKK Deubiquitinase Autophagy Apoptosis NF-κB	Inflammation/Immunology Cancer
BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC₅₀=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells .

HY-149604

NLRP3-IN-21	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-21 (compound L38) is a NLRP3 inflammasome inhibitor with inflammatory properties. NLRP3-IN-21 inhibits NLRP3 inflammasome activation and pyroptosis by suppressing gasdermin D cleavage, ASC oligomerization, and NLRP3 inflammasome assembly .

HY-161727

P2Y14R antagonist 1	P2Y Receptor NOD-like Receptor (NLR)	Inflammation/Immunology
P2Y14R antagonist 1 (compound I-17) is a selective P2Y14R antagonist with an IC₅₀ of 0.6 nM. It exhibits potent P2Y14R antagonistic activity, both in vitro and in vivo efficacy, and favorable pharmacokinetic profiles. P2Y14R antagonist 1 reduces the release of inflammatory factors and cell pyroptosis through the NOD-like receptor family pyrin domain-containing 3 (NLRP3)/gasdermin D (GSDMD) signaling pathway. P2Y14R antagonist 1 holds promise for research in the field of acute gouty arthritis .

HY-B0240R

Disulfiram (Standard)	Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis	Metabolic Disease Cancer
Disulfiram (Standard) is the analytical standard of Disulfiram. This product is intended for research and analytical applications. Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram + Cu ²⁺ increases intracellular ROS levels triggering apoptosis of ovarian cancer stem cells ^[1-6].

Cat. No.	Product Name

HY-L059

Pyroptosis Compound Library	1,352 compounds
Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc. MCE designs a unique collection of 1,352 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.

Pyroptosis Compound Library

1,352 compounds

Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc.

MCE designs a unique collection of 1,352 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81230

	GSDMD Antibody DF 5L; DF5L; DFNA 5L; DFNA5L; FKSG 10; FKSG10; FLJ12150; gasdermin D; gasdermin domain containing 1; gasdermin domain containing protein 1; gasdermin domain-containing protein 1; gasdermin-D; gasderminD; GSDMD_HUMAN; GSDMDC 1; GSDMDC1; gasdermin-D, N-terminal; GSDMD-NT; hGSDMD-NTD; gasdermin-D, C-terminal; GSDMD-CT; hGSDMD-CTD.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human
	GSDMD Antibody is an unconjugated, approximately 53 kDa, rabbit-derived, anti-GSDMD polyclonal antibody. GSDMD Antibody can be used for: WB, ELISA, IHC-P, IHC-F, ICC, IF expriments in human, and predicted: mouse, rat background without labeling.

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