2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NLRP3-IN-21

NLRP3-IN-21 (compound L38) is a NLRP3 inflammasome inhibitor with inflammatory properties. NLRP3-IN-21 inhibits NLRP3 inflammasome activation and pyroptosis by suppressing gasdermin D cleavage, ASC oligomerization, and NLRP3 inflammasome assembly.

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NLRP3-IN-21 Chemical Structure

NLRP3-IN-21 Chemical Structure

CAS No. : 2956791-61-8

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Based on 1 publication(s) in Google Scholar

NLRP3-IN-21 Related Antibodies

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Description

NLRP3-IN-21 (compound L38) is a NLRP3 inflammasome inhibitor with inflammatory properties. NLRP3-IN-21 inhibits NLRP3 inflammasome activation and pyroptosis by suppressing gasdermin D cleavage, ASC oligomerization, and NLRP3 inflammasome assembly[1].

Molecular Weight

529.32

Formula

C20H13Cl2F3N6O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(N=C(N2C1=CC3=C2C=C(S3)Cl)C(C)C)CC4=NN=C(O4)C5=CC=C(N=C5Cl)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (188.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8892 mL 9.4461 mL 18.8922 mL
5 mM 0.3778 mL 1.8892 mL 3.7784 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8892 mL 9.4461 mL 18.8922 mL 47.2304 mL
5 mM 0.3778 mL 1.8892 mL 3.7784 mL 9.4461 mL
10 mM 0.1889 mL 0.9446 mL 1.8892 mL 4.7230 mL
15 mM 0.1259 mL 0.6297 mL 1.2595 mL 3.1487 mL
20 mM 0.0945 mL 0.4723 mL 0.9446 mL 2.3615 mL
25 mM 0.0756 mL 0.3778 mL 0.7557 mL 1.8892 mL
30 mM 0.0630 mL 0.3149 mL 0.6297 mL 1.5743 mL
40 mM 0.0472 mL 0.2362 mL 0.4723 mL 1.1808 mL
50 mM 0.0378 mL 0.1889 mL 0.3778 mL 0.9446 mL
60 mM 0.0315 mL 0.1574 mL 0.3149 mL 0.7872 mL
80 mM 0.0236 mL 0.1181 mL 0.2362 mL 0.5904 mL
100 mM 0.0189 mL 0.0945 mL 0.1889 mL 0.4723 mL
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NLRP3-IN-21 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-212956791-61-8NOD-like Receptor (NLR)NACHT domainNLRP3 Inflammasomegasdermin DASC oligomerizationInhibitorinhibitorinhibit

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