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gene delivery

" in MedChemExpress (MCE) Product Catalog:

37

Inhibitors & Agonists

27

Biochemical Assay Reagents

8

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2

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1

Click Chemistry

27

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W250110B
    Polyethylenimine (linear, average Mn 2100, PDI<1.3)

    PEI (linear, average Mn 2100, PDI<1.3)

    		 Biochemical Assay Reagents Cancer
    Polyethylenimine (PEI) (linear, average Mn 2100, PDI<1.3), a cationic polymer, is a non-viral gene delivery vector, especially for oligonucleotide delivery .
    Polyethylenimine (linear, average Mn 2100, PDI<1.3)
  • HY-149037A
    GL67 pentahydrochloride

    N4-Spermine cholesteryl carbamate pentahydrochloride

    		 Liposome Others
    GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .
    GL67 pentahydrochloride
  • HY-134783
    1,19-Bis(2-butyloctyl) 10-[[3-(dimethylamino)propyl](1-oxononyl)amino]nonadecanedioate

    		Liposome Others
    1,19-Bis(2-butyloctyl) 10-[[3-(dimethylamino)propyl](1-oxononyl)amino]nonadecanedioate is an excipient for vaccines. 1,19-Bis(2-butyloctyl) 10-[[3-(dimethylamino)propyl](1-oxononyl)amino]nonadecanedioate can be used for the research of the development of COVID-19 vaccines and drug delivery for gene therapy .
    1,19-Bis(2-butyloctyl) 10-[[3-(dimethylamino)propyl](1-oxononyl)amino]nonadecanedioate
  • HY-144022
    16:0 DAP

    		Liposome Others
    16:0 DAP is a cationic lipids that can be used for drug delivery, gene transfection and vaccine delivery .
    16:0 DAP
  • HY-144001
    DSPE-PEG-Carboxylic Acid

    		Liposome Others
    DSPE-PEG-Carboxylic Acid is a phospholipid PEG conjugate. DSPE-PEG-Carboxylic Acid can be widely used in the delivery of targeted agents and genes .
    DSPE-PEG-Carboxylic Acid
  • HY-142995
    DODAP hydrochloride

    		Liposome Others
    DODAP (hydrochloride) is an ionizable lipid. DODAP (hydrochloride) has the potential for the research of gene delivery .
    DODAP hydrochloride
  • HY-149664
    3β-[N-(N′,N′-Dimethylaminoethyl)carbamoyl]cholesterol

    DC-Chol

    		 Liposome Cancer
    3β-[N-(N′,N′-Dimethylaminoethyl)carbamoyl]cholesterol, a lipid, has been investigated in cancer gene therapy and vaccine delivery system .
    3β-[N-(N′,N′-Dimethylaminoethyl)carbamoyl]cholesterol
  • HY-149037
    GL67

    N4-Spermine cholesteryl carbamate

    		 Liposome Others
    GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .
    GL67
  • HY-160576
    DNCA

    		Liposome Cancer
    DNCA is a neutral lipid that can be used in the generation of lipid nanoparticles (LNPs). DNCA can be used in nucleic acid delivery .
    DNCA
  • HY-166997
    AL-A12

    		Liposome Others
    AL-A12 is a short-chain amino lipid with high gene delivery efficiency and low toxicity, and can be used in drug delivery research .
    AL-A12
  • HY-138170
    ALC-0315
    Maximum Cited Publications
    15 Publications Verification

    		 Liposome SARS-CoV Infection
    ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .
    ALC-0315
  • HY-138170A
    ALC-0315 (Excipient)

    		Liposome SARS-CoV Infection
    ALC-0315 Excipient is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 Excipient can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .
    ALC-0315 (Excipient)
  • HY-W440827
    DOPE-PEG-COOH (MW 2000)
    1 Publications Verification

    		 Liposome Cancer
    DOPE-PEG-COOH (MW 2000) is a PEG-based PROTAC linker. DOPE-PEG-COOH (MW 2000) can be used in the synthesis of PROTACs. DOPE-PEG-COOH (MW 2000) can be used for drug delivery, gene transfection and vaccine delivery .
    DOPE-PEG-COOH (MW 2000)
  • HY-145523
    OH-Chol

    		Liposome Others
    OH-Chol is a cationic cholesterol derivative. OH-Chol can be used for siRNA delivery and gene silencing .
    OH-Chol
  • HY-145794
    ZA3-Ep10

    		Liposome Others
    ZA3-Ep10 is a zwitterionic lipid used in lipid nanoparticles formulation for in vivo RNA delivery and non-viral CRISPR/Cas gene editing.
    ZA3-Ep10
  • HY-137499
    NT1-O12B

    		Liposome Endogenous Metabolite Neurological Disease
    NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination .
    NT1-O12B
  • HY-158709
    Cho-es-Lys

    		Biochemical Assay Reagents Liposome Others
    Cho-es-Lys is a cationic lipid synthesized by coupling natural cholesterol and amino acids, which has high gene transfection efficiency. Cho-es-Lys can be used in drug delivery research .
    Cho-es-Lys
  • HY-W250110
    Polyethylenimine (branched)
    3 Publications Verification

    		 Biochemical Assay Reagents Infection Others
    Polyethylenimine (PEI) branched is a organic macromolecule with high cationic-charge-density potential. PEI can ensnare DNA as well as attach to cell membrane, PEI also retains a substantial buffering capacity at virtually any pH. PEI is widely used as transfection reagent .
    Polyethylenimine (branched)
  • HY-W250110R
    Polyethylenimine (branched) (Standard)

    		Biochemical Assay Reagents Infection Others
    Polyethylenimine (branched) (Standard) is the analytical standard of Polyethylenimine (branched). This product is intended for research and analytical applications. Polyethylenimine (PEI) branched is a organic macromolecule with high cationic-charge-density potential. PEI can ensnare DNA as well as attach to cell membrane, PEI also retains a substantial buffering capacity at virtually any pH. PEI is widely used as transfection reagent .
    Polyethylenimine (branched) (Standard)
  • HY-164035
    DOPE-PEG-DBCO (MW 2000)

    		Biochemical Assay Reagents Others
    DOPE-PEG-DBCO (MW 2000) is a PEG lipid with a DOPE and a DBCO as functional groups. DOPE can be used as a helper lipid in gene transfection. PEG is used in drug delivery system. DBCO can be used for click chemistry .
    DOPE-PEG-DBCO (MW 2000)
  • HY-159675
    1-A-N

    		Liposome Inflammation/Immunology
    1-A-N is a lipid nanoparticle (LNP) used for in vivo delivery of siRNA. 1-A-N can regulate immune response by delivering siCD45 (siRNA targeting CD45) to T cells and silencing the CD45 gene .
    1-A-N
  • HY-151513
    Iso5-2DC18

    		Others Cancer
    Iso5-2DC18 is a lipid that can be used for the synthesis of amine containing lipids. These amine containing lipids can be used for mRNA delivery, activate the stimulator of interferon genes (STING) pathway, and exhibit anti-tumor immunity .
    Iso5-2DC18
  • HY-160852
    YSK 12C4

    		Liposome Inflammation/Immunology
    YSK 12C4 is an ionizable cationic lipid primarily used to enhance siRNA cellular delivery via multifunctional envelope-type nanodevices (MEND). YSK 12C4 promotes siRNA uptake and endosomal escape, effectively silencing genes in human immune cell lines .
    YSK 12C4
  • HY-159067
    DEAE-dextran, MW 500000 hydrochloride

    DEAE-dextran, MW 500000 (hydrochloride), from bacterial (Leuconostoc mesenteroides); Diethylaminoethyl-dextran, MW 500000 hydrochloride

    		 Biochemical Assay Reagents Cancer
    DEAE-dextran, MW 500000 hydrochloride (DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides)) is a high-molecular-weight positively charged polymer that significantly enhances the uptake of viral RNA by tissue culture cells. When employed in the delivery system for "tumor immunity" RNA-splenocyte transfer, DEAE-dextran can markedly extend the lifespan of tumor-bearing animals, comparable to that of actively immunized animals. Furthermore, DEAE-dextran serves as a complexing agent for nucleic acids, forming composite particles with DNA/RNA for extensive applications in gene delivery. Additionally, DEAE-dextran can be utilized as a coating for liposomes .
    DEAE-dextran, MW 500000 hydrochloride
  • HY-160581
    OH-C-Chol

    		Liposome Others
    OH-C-Chol is a cationic liposome that serves as a siRNA delivery vehicle. OH-C-Chol (LP-C) and OH-NC-Chol (LP-NC)/siRNA complexes (lipoplexes) showed better performance than NP-C and NP-NC/siRNA complexes (nanocomplexes), respectively. ) greater gene silencing effect .
    OH-C-Chol
  • HY-147087
    YSK 05

    		Liposome Cancer
    YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .
    YSK 05
  • HY-W591476
    m-PEG-thiol (MW 1000)

    mPEG-SH (MW 1000)

    		 Biochemical Assay Reagents Others
    m-PEG-thiol (MW 1000) modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.
    m-PEG-thiol (MW 1000)
  • HY-W591476A
    m-PEG-thiol (MW 3400)

    mPEG-SH (MW 3400)

    		 Biochemical Assay Reagents Others
    m-PEG-thiol (MW 3400) modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.
    m-PEG-thiol (MW 3400)
  • HY-W591476B
    m-PEG-thiol (MW 750)

    mPEG-SH (MW 750)

    		 Biochemical Assay Reagents Others
    m-PEG-thiol (MW 750) modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.
    m-PEG-thiol (MW 750)
  • HY-W591476C
    m-PEG-thiol (MW 550)

    mPEG-SH (MW 550)

    		 Biochemical Assay Reagents Others
    m-PEG-thiol (MW 550) modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.
    m-PEG-thiol (MW 550)
  • HY-W591476D
    m-PEG-thiol (MW 350)

    mPEG-SH (MW 350)

    		 Biochemical Assay Reagents Others
    m-PEG-thiol (MW 350) modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.
    m-PEG-thiol (MW 350)
  • HY-N3540
    Caraphenol A

    		Others Inflammation/Immunology
    Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC50s of 5.9 μM and 12.1 μM, respectively .
    Caraphenol A
  • HY-153231
    eGFP mRNA-LNP

    		Fluorescent Dye Liposome Others
    eGFP mRNA-LNP is a lipid nanoparticle (LNP) containing eGFP mRNA, suitable for assays of RNA delivery, translation efficiency, cell viability, etc. eGFP circRNA carries Enhanced Green Fluorescent Protein (Enhanced Green Fluorescent Protein) eGFP, which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry .
    eGFP mRNA-LNP
  • HY-153232
    eGFP circRNA-LNP

    		Fluorescent Dye Liposome Others
    eGFP circRNA-LNP is a lipid nanoparticle (LNP) containing eGFP circRNA, suitable for assays of RNA delivery, translation efficiency, cell viability, etc. eGFP circRNA carries Enhanced Green Fluorescent Protein (Enhanced Green Fluorescent Protein) eGFP, which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry .
    eGFP circRNA-LNP
  • HY-112758
    DLin-KC2-DMA
    4 Publications Verification

    		 Liposome Others
    DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .
    DLin-KC2-DMA
  • HY-131119
    Dimethyldioctadecylammonium bromide

    Dioctadecyldimethylammonium bromide; DODAB

    		 Liposome Others
    Dimethyldioctadecylammonium bromide is a synthetic cationic lipid commonly used in gene delivery and vaccine development. Also known as DODAB or DDAB, it consists of a positively charged ammonium head group and two long hydrophobic tails. These properties make it useful for forming liposomes and other lipid-based nanoparticles that can efficiently deliver genetic material into cells. In addition to its applications in biotechnology, DDAB is also used in surfactants, emulsifiers and fabric softeners. However, due to its potential toxicity and irritation, extreme care should be taken when handling DDAB.
    Dimethyldioctadecylammonium bromide
  • HY-W250187
    DDMAB

    		Biochemical Assay Reagents Others
    DDMAB, or didodecyldimethylammonium bromide, is a cationic surfactant commonly used in a variety of industrial and research applications. It belongs to the family of quaternary ammonium compounds and has a positively charged head and a hydrophobic tail, which allows it to be used as a detergent, emulsifier and antimicrobial. Known for its ability to disrupt cell membranes, DDMAB is commonly used in microbiology to selectively isolate and identify bacteria. It is also used in nanotechnology to synthesize metal nanoparticles and other materials. In addition, DDMAB has the ability to interact with and penetrate cell membranes, which has potential applications in drug delivery, gene therapy, and other medical fields.
    DDMAB

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