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Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells. Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC50s of 5.9 μM and 12.1 μM, respectively.

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Caraphenol A Chemical Structure

Caraphenol A Chemical Structure

CAS No. : 354553-35-8

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Caraphenol A Related Antibodies

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Description

Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells[1]. Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC50s of 5.9 μM and 12.1 μM, respectively[2].

IC50 & Target

IFITM2, IFITM3[1]
IC50: 5.9 μM (hCBS), 12.1 μM (hCSE)[2]
In Vitro

Caraphenol A (0-50 μM; 8 h) enhances lentiviral vector (LV) gene delivery to HeLa, but not HEK293T cells[1].
Caraphenol A decreases interferon induced transmembrane protein-mediated restriction in an endosomal trafficking dependent manner[1].
Caraphenol A treatment significantly improves hematopoietic stem cell (HSC) gene delivery at both low and high LV doses without altering LV integration patterns[1].
Caraphenol A (30 μM; 6 h) treatment facilitates lentiviral escape from endosomes[1].
Caraphenol A (30 μM; 4 h) alters expression and subcellular localization of IFITM2/3 protein and late endosomes in HeLa cells. The effect on late endosome is dependent on IFITM3 expression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Caraphenol A Related Antibodies
In Vivo

Caraphenol A-treated (30 μM; pretreated for 4 h) HSCs maintain improved gene marking in mice without altering lentiviral integration profiles[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

676.67

Formula

C42H28O9
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

[H][C@]12[C@@H](OC3=C1C([C@@]4([C@H](OC5=C4C(C6=C(OC7=C6C2=CC(O)=C7)C8=CC=C(O)C=C8)=CC(O)=C5)C9=CC=C(O)C=C9)[H])=CC(O)=C3)C%10=CC=C(O)C=C%10
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (73.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4778 mL 7.3891 mL 14.7783 mL
5 mM 0.2956 mL 1.4778 mL 2.9557 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 92.57%

SDS (251 KB)

COA (265 KB) HNMR (206 KB) LCMS (77 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4778 mL 7.3891 mL 14.7783 mL 36.9456 mL
5 mM 0.2956 mL 1.4778 mL 2.9557 mL 7.3891 mL
10 mM 0.1478 mL 0.7389 mL 1.4778 mL 3.6946 mL
15 mM 0.0985 mL 0.4926 mL 0.9852 mL 2.4630 mL
20 mM 0.0739 mL 0.3695 mL 0.7389 mL 1.8473 mL
25 mM 0.0591 mL 0.2956 mL 0.5911 mL 1.4778 mL
30 mM 0.0493 mL 0.2463 mL 0.4926 mL 1.2315 mL
40 mM 0.0369 mL 0.1847 mL 0.3695 mL 0.9236 mL
50 mM 0.0296 mL 0.1478 mL 0.2956 mL 0.7389 mL
60 mM 0.0246 mL 0.1232 mL 0.2463 mL 0.6158 mL
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Caraphenol A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Caraphenol A354553-35-8Othersgene therapyhematopoietic stem cellHSClentiviral vectorIFITMinterferon-induced transmembrane proteinInhibitorinhibitorinhibit

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