DEAE-dextran, MW 500000 hydrochloride  (Synonyms: DEAE-dextran, MW 500000 (hydrochloride), from bacterial (Leuconostoc mesenteroides); Diethylaminoethyl-dextran, MW 500000 hydrochloride)

DEAE-dextran, MW 500000 hydrochloride (DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides)) is a high-molecular-weight positively charged polymer that significantly enhances the uptake of viral RNA by tissue culture cells. When employed in the delivery system for "tumor immunity" RNA-splenocyte transfer, DEAE-dextran can markedly extend the lifespan of tumor-bearing animals, comparable to that of actively immunized animals. Furthermore, DEAE-dextran serves as a complexing agent for nucleic acids, forming composite particles with DNA/RNA for extensive applications in gene delivery. Additionally, DEAE-dextran can be utilized as a coating for liposomes^[1][2].

500000 (Average)

9064-91-9

[DEAE-dextran, MW 500000 (hydrochloride)]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Rigby P G. Prolongation of survival of tumour-bearing animals by transfer of “immune” RNA with DEAE dextran[J]. Nature, 1969, 221(5184): 968-969.  [Content Brief]

  [2]. Siewert C, et al. Investigation of charge ratio variation in mRNA–DEAE-dextran polyplex delivery systems[J]. Biomaterials, 2019, 192: 612-620.  [Content Brief]