Polyethylenimine (linear, average Mn 2100, PDI<1.3)  (Synonyms: PEI (linear, average Mn 2100, PDI<1.3))

Polyethylenimine (linear, average Mn 2100, PDI<1.3), a linear cationic polymer, is a versatile non-viral gene delivery vector, especially for oligonucleotide delivery. Polyethylenimine (linear, average Mn 2100, PDI<1.3) condenses DNA into positively charged particles that bind to anionic cell surfaces. Polyethylenimine (PEI) can be used in detergents, adhesives, water treatment agents and cosmetics^[1][2][3].

Tansfection efficiency is maximal at ≈9-13.5 equivalents of Polyethylenimine (linear, average Mn 2100, PDI<1.3) nitrogen per DNA phosphate and Polyethylenimine (linear, average Mn 2100, PDI<1.3)/DNA ratio to 18 does not significantly affect cellular metabolism in HeLa cells^[3].
Polyethylenimine (linear, average Mn 2100, PDI<1.3) gives transfection levels of the same order as lipopolyamines for various cell lines and primary cells in vitro^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Polyethylenimine (linear, average Mn 2100, PDI<1.3) (injected into the brains of newborn mice, a single dose for 24 h) is a highly efficient vector for delivering oligonucleotides and plasmids in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(C₂H₅N)n

9002-98-6

Solid

White to off-white

CNCCC

Room temperature in continental US; may vary elsewhere.

• [1]. Fei Hao, et al. Polyethylenimine-based Formulations for Delivery of Oligonucleotides. Curr Med Chem. 2019;26(13):2264-2284.  [Content Brief]

  [2]. Longo PA, et al. Transient mammalian cell transfection with polyethylenimine (PEI). Methods Enzymol. 2013;529:227-40.  [Content Brief]

  [3]. Boussif O, et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7297-301.  [Content Brief]