2. Metabolic Enzyme/Protease
  3. Liposome
  4. YSK 05

YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo.

For research use only. We do not sell to patients.

YSK 05 Chemical Structure

YSK 05 Chemical Structure

CAS No. : 1318793-78-0

Size Price Stock Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 117 In-stock
Solution
10 mM * 1 mL in DMSO USD 117 In-stock
Liquid
5 mg USD 85 In-stock
10 mg USD 145 In-stock
25 mg USD 300 In-stock
50 mg USD 485 In-stock
100 mg USD 760 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

YSK 05 Related Antibodies

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Description

YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo[1].

In Vitro

YSK 05 facilitates the endosomal escape of the MEND and thereby enhances the efficacy of siRNA delivery into cytosol and gene silencing[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

YSK 05 Related Antibodies
Molecular Weight

628.07

Formula

C42H77NO2
CAS No.
Appearance

Liquid (Density: 0.91±0.1 g/cm3)

Color

Colorless to light yellow

SMILES

CN1CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)(OCCCCCCCC/C=C\C/C=C\CCCCC)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (159.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5922 mL 7.9609 mL 15.9218 mL
5 mM 0.3184 mL 1.5922 mL 3.1844 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (241 KB) HNMR (131 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5922 mL 7.9609 mL 15.9218 mL 39.8045 mL
5 mM 0.3184 mL 1.5922 mL 3.1844 mL 7.9609 mL
10 mM 0.1592 mL 0.7961 mL 1.5922 mL 3.9804 mL
15 mM 0.1061 mL 0.5307 mL 1.0615 mL 2.6536 mL
20 mM 0.0796 mL 0.3980 mL 0.7961 mL 1.9902 mL
25 mM 0.0637 mL 0.3184 mL 0.6369 mL 1.5922 mL
30 mM 0.0531 mL 0.2654 mL 0.5307 mL 1.3268 mL
40 mM 0.0398 mL 0.1990 mL 0.3980 mL 0.9951 mL
50 mM 0.0318 mL 0.1592 mL 0.3184 mL 0.7961 mL
60 mM 0.0265 mL 0.1327 mL 0.2654 mL 0.6634 mL
80 mM 0.0199 mL 0.0995 mL 0.1990 mL 0.4976 mL
100 mM 0.0159 mL 0.0796 mL 0.1592 mL 0.3980 mL
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YSK 05 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YSK 051318793-78-0YSK05YSK-05LiposomeOS-RC-2 cellsmultifunctional envelope-type nano deviceMENDsiRNA deliverypH-sensitive cationic lipidIntracellular traffickingEndosomal escapeInhibitorinhibitorinhibit

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