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  4. GL67 pentahydrochloride

GL67 pentahydrochloride  (Synonyms: N4-Spermine cholesteryl carbamate pentahydrochloride)

Cat. No.: HY-149037A Purity: 98.60%
SDS COA Handling Instructions

Molarity Calculator

GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection.

For research use only. We do not sell to patients.

GL67 pentahydrochloride Chemical Structure

GL67 pentahydrochloride Chemical Structure

Size Price Stock Quantity
5 mg USD 200 In-stock
10 mg USD 350 In-stock
25 mg USD 700 In-stock
50 mg USD 1150 In-stock
100 mg USD 1850 In-stock
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500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection[1].

Molecular Weight

797.29

Formula

C38H75Cl5N4O2
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OC(N(CCCN)CCCCNCCCN)=O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C.[H]Cl.[H]Cl.[H]Cl.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (125.42 mM)

DMSO : 5 mg/mL (6.27 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2542 mL 6.2712 mL 12.5425 mL
5 mM 0.2508 mL 1.2542 mL 2.5085 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.60%

SDS (252 KB)

COA (248 KB) HNMR (312 KB) RP-HPLC (257 KB) MS (73 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.2542 mL 6.2712 mL 12.5425 mL 31.3562 mL
5 mM 0.2508 mL 1.2542 mL 2.5085 mL 6.2712 mL
H2O 10 mM 0.1254 mL 0.6271 mL 1.2542 mL 3.1356 mL
15 mM 0.0836 mL 0.4181 mL 0.8362 mL 2.0904 mL
20 mM 0.0627 mL 0.3136 mL 0.6271 mL 1.5678 mL
25 mM 0.0502 mL 0.2508 mL 0.5017 mL 1.2542 mL
30 mM 0.0418 mL 0.2090 mL 0.4181 mL 1.0452 mL
40 mM 0.0314 mL 0.1568 mL 0.3136 mL 0.7839 mL
50 mM 0.0251 mL 0.1254 mL 0.2508 mL 0.6271 mL
60 mM 0.0209 mL 0.1045 mL 0.2090 mL 0.5226 mL
80 mM 0.0157 mL 0.0784 mL 0.1568 mL 0.3920 mL
100 mM 0.0125 mL 0.0627 mL 0.1254 mL 0.3136 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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GL67 pentahydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GL67 pentahydrochlorideN4-Spermine cholesteryl carbamate pentahydrochlorideLiposomelipidnucleic acidvaccinedeliverygene transfectionInhibitorinhibitorinhibit

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