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Results for "

intermediate metabolite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Intermediate (1) Drug Metabolite (8) Endogenous Metabolite (23) Bacterial (1) COX (3) Cytochrome P450 (1) Histone Methyltransferase (1) Isotope-Labeled Compounds (5) Prostaglandin Receptor (1) Reactive Oxygen Species (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (8) Metabolic Disease (18) Neurological Disease (5)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Intermediate Drug Metabolite Endogenous Metabolite

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7061

Tropine	Others	Neurological Disease
Tropine is a secondary metabolite of Solanaceae plants, is an anticholinergic agent . Tropine is a common intermediate in the synthesis of a variety of bioactive alkaloids, including hyoscyamine and scopolamine .

HY-114950

EXP3179 Losartan Carboxaldehyde; DuP 167	COX	Cardiovascular Disease Inflammation/Immunology
EXP3179 is an important intermediate aldehyde metabolite of Losartan. EXP3179 has no AT1-R–blocking activity, but potently inhibits the expression of endothelial cyclooxygenase (COX)-2. EXP3179 exerts potent anti-inflammatory actions .

HY-164093

Isovaleryl-CoA	Endogenous Metabolite	Metabolic Disease
Isovaleryl-CoA is an intermediate metabolite in the catabolic pathway of leucine. Isovaleryl-CoA is the starting unit for some secondary metabolites and iso-odd fatty acids in several bacteria .

HY-N7061R

Tropine (Standard)	Others	Neurological Disease
Tropine (Standard) is the analytical standard of Tropine. This product is intended for research and analytical applications. Tropine is a secondary metabolite of Solanaceae plants, is an anticholinergic agent . Tropine is a common intermediate in the synthesis of a variety of bioactive alkaloids, including hyoscyamine and scopolamine .

HY-141465

3-Hydroxybutyryl-CoA	Endogenous Metabolite	Metabolic Disease
3-Hydroxybutyryl-CoA is a metabolite which can be found in mouse or E.coli, et al. 3-Hydroxybutyryl-CoA has a 3-hydroxybutanoyl as the S-acyl component, and is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan .

HY-164805

N-Lactylleucine	Endogenous Metabolite	Others
N-Lactylleucine is an endogenous metabolite that can be identified in patients with the intermediate type of maple syrup urine disease .

HY-164804

N-Lactylvaline	Endogenous Metabolite	Metabolic Disease
N-Lactylvaline is an endogenous metabolite that can be identified in patients with the intermediate type of maple syrup urine disease .

HY-114950R

EXP3179 (Standard)	COX	Cardiovascular Disease Inflammation/Immunology
EXP3179 (Standard) is the analytical standard of EXP3179. This product is intended for research and analytical applications. EXP3179 is an important intermediate aldehyde metabolite of Losartan. EXP3179 has no AT1-R–blocking activity, but potently inhibits the expression of endothelial cyclooxygenase (COX)-2. EXP3179 exerts potent anti-inflammatory actions .

HY-W587960

Hercynine Histidine-betaine	Drug Metabolite	Metabolic Disease
Hercynine (Histidine-betaine) is an intermediate (precursor) and a redox metabolite of Ergothioneine (HY-N1914), which is found in the fine leaf algae, Schizosaccharomyces cerevisiae and honey bees. Hercynine has no effect on scavenging •OH radicals .

HY-N8060

Orotidine 5′-monophosphate Orotidine monophosphate; Orotidylic acid	Endogenous Metabolite	Others
Orotidine 5′-monophosphate is a pyrimidine ribonucleoside and plays a role as an endogenous metabolite of human, E. coli or mouse. Orotidine 5′-monophosphate is an intermediate in the biosynthesis of?uridine monophosphate (UMP). Orotidine 5′-monophosphate can be used for the study of mechanism of orotidine 5′-monophosphate decarboxylase .

HY-Y0781

Pyruvic acid Maximum Cited Publications 9 Publications Verification Acetylformic acid	Endogenous Metabolite	Others
Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.

HY-W004360

BIBR 1087 SE Desethyl Dabigatran Etexilate	Others	Metabolic Disease Inflammation/Immunology
BIBR 1087 SE is an intermediate metabolite of dabigatran etexilate.

HY-W017524

2-Methylpentanedioic acid 1 Publications Verification	Endogenous Metabolite	Others
2-Methylpentanedioic acid is a metabolite of succinic acid, a citric acid cycle intermediate.

HY-Y1117

Melamine	Drug Metabolite	Others
Melamine is a *metabolite* of cyromazine. Melamine is a intermediate for the synthesis of melamine resin and plastic materials .

HY-W711166

4-(2-Acetoxyacetyl)phenyl acetate	Drug Intermediate	Others
4-(2-Acetoxyacetyl)phenyl acetate is a synthetic intermediate that has been used in the synthesis of phenethylamine metabolites.

HY-113126

3-Hydroxyisobutyric acid	Endogenous Metabolite	Others
3-Hydroxyisobutyric acid is an important interorgan metabolite, an intermediate in the pathways of l-valine and thymine and a good gluconeogenic substrate.

HY-113126A

3-Hydroxyisobutyric acid sodium	Endogenous Metabolite	Others
3-Hydroxyisobutyric acid sodium is an important interorgan metabolite, an intermediate in the pathways of l-valine and thymine and a good gluconeogenic substrate.

HY-Y0781S

Pyruvic acid-13C sodium Acetylformic acid-¹³C sodium	Endogenous Metabolite	Others
Pyruvic acid- ¹³C (sodium) is the ¹³C-labeled Pyruvic acid. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.

HY-126126

S-Adenosyl-DL-methionine	Others	Others
S-Adenosyl-DL-methionine is a derivative of Ademetionine (HY-B0617). Ademetionine is an intermediate metabolite of methionine .

HY-W354479

6-Thioinosine Phosphate Thioinosinic acid	Drug Metabolite	Inflammation/Immunology
6-Thioinosine Phosphate (Thioinosinic acid) is an intermediate metabolite of azathioprine (HY-B0256). Azathioprine is a purine analog immunosuppressive drug .

HY-108416

5,7-Dihydroxy-4-methylphthalide	Others	Others
5,7-Dihydroxy-4-methylphthalide is a key intermediate in the synthesis of Mycophenolic acid and a secondary metabolite of Aspergillus flavus .

HY-Y0781R

Pyruvic acid (Standard)	Endogenous Metabolite	Others
Pyruvic acid (Standard) is the analytical standard of Pyruvic acid. This product is intended for research and analytical applications. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.

HY-W753983

Pyruvic acid-13C3 Acetylformic acid-¹³C₃	Isotope-Labeled Compounds	Metabolic Disease
Pyruvic acid-13C is isotype-labeled compound of Pyruvic acid. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats .

HY-Y0781S1

Pyruvic acid-13C Acetylformic acid-¹³C	Endogenous Metabolite	Others
Pyruvic acid- ¹³C is the ¹³C labeled Pyruvic acid[1]. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats[2].

HY-Y1117S

Melamine-15N3	Isotope-Labeled Compounds	Others
Melamine- ¹⁵N₃ is a ¹⁵N-labeled Melamine. Melamine is a metabolite of cyromazine. Melamine is a intermediate for the synthesis of melamine resin and plastic materials[1].

HY-Y1117R

Melamine (Standard)	Drug Metabolite	Others
Melamine (Standard) is the analytical standard of Melamine. This product is intended for research and analytical applications. Melamine is a *metabolite*?of?cyromazine. Melamine is a intermediate for the synthesis of melamine resin and plastic materials .

HY-13938

Iretol 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Iretol (2,4,6-trihydroxyanisole) is a a degradation product of a glucoside obtained from Iris Jorentina. Iretol is an intermediate in the synthesis of natural isoflavones, such as Tectorigenin, Irigenin and Caviunin .

HY-125598

Secologanin	Cytochrome P450	Others
Secologanin, a secoiridoid glucoside, is a pivotal terpenoid intermediate in the biosynthesis of biologically active monoterpenoid indole alkaloids such as reserpine, ajmaline, and vinblastine. Secologanin synthase (cytochrome P450 isoform CYP72A1) catalyzes the oxidative cleavage of loganin into Secologanin .

HY-Y0781S3

Pyruvic acid-13C-2 sodium Acetylformic acid-¹³C-2 sodium	Endogenous Metabolite	Others
Pyruvic acid- ¹³C-2 (sodium) is the ¹³C labeled Pyruvic acid[1]. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats[2].

HY-W040971

Creosol 2-Methoxy-4-methylphenol	Endogenous Metabolite	Metabolic Disease
Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass .

HY-Y1117S1

Melamine-13C3	Isotope-Labeled Compounds	Others
Melamine-13C3 is the 13C labeled Melamine[1]. Melamine is a metabolite of cyromazine. Melamine is a intermediate for the synthesis of melamine resin and plastic materials[2].

HY-B2124

10,11-Dihydrocarbamazepine	Drug Metabolite	Neurological Disease
10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy .

HY-101677

cPrPMEDAP	Drug Metabolite	Infection
cPrPMEDAP is an intermediate metabolite of GS-9219. cpr-PMEDAP functions as a proagent of the guanine nucleotide analog PMEG and has antiproliferative activity. cPrPMEDAP is negatively charged at physiologic pH and has poor permeability into the skin .

HY-W008452

H-Tyr(3-I)-OH	Endogenous Metabolite	Metabolic Disease
H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .

HY-Y1117S2

Melamine-15N3,13C3	Isotope-Labeled Compounds	Others
Melamine- ¹⁵N₃, ¹³C₃ is a ¹³C- and ¹⁵N-labeled Melamine (HY-Y1117). Melamine is a *metabolite*?of?cyromazine. Melamine is a intermediate for the synthesis of melamine resin and plastic materials .

HY-W717548

Safinamide acid	Drug Metabolite	Others
Safinamide acid (Compound Imp-E) is the metabolite of Safinamide (HY-70057). Safinamide acid can be formed by hydrolysis of Safinamide intermediate under alkaline or acidic conditions. Safinamide acid is utilized to monitor process-related impurities and degradation products in safinamide samples .

HY-136592

1-Hydroxy-ibuprofen	COX	Inflammation/Immunology Cancer
1-Hydroxy Ibuprofen is a metabolite of Ibuprofen in P. australis . Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively .

HY-113381A

(R)-2-Hydroxybutanoic acid (R)-α-Hydroxybutyric acid	Others	Metabolic Disease
(R)-2-Hydroxybutanoic acid is the isomer of 2-Hydroxybutyric acid (HY-113381), and can be used as an experimental control. 2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite .

HY-113381B

(R)-2-Hydroxybutanoic acid sodium (R)-α-Hydroxybutyric acid sodium	Others	Others
(R)-2-Hydroxybutanoic acid ((R)-α-Hydroxybutyric acid) sodium is the R-isomer of 2-Hydroxybutyric acid (HY-113381), and can be used as an experimental control. 2-Hydroxybutyric acid is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite .

HY-W040971R

Creosol (Standard)	Endogenous Metabolite	Metabolic Disease
Creosol (Standard) is the analytical standard of Creosol. This product is intended for research and analytical applications. Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass .

HY-W008452S

H-Tyr(3-I)-OH-13C6	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
H-Tyr(3-I)-OH- ¹³C₆ is the ¹³C-labeled H-Tyr(3-I)-OH. H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite[1][2].

HY-113407A

D-Fructose-6-phosphate disodium	Endogenous Metabolite	Metabolic Disease
D-Fructose-6-phosphate disodium is an endogenous metabolite. D-Fructose-6-phosphate can be converted into D-glucose 6-phosphate (HY-112537) under the action of phosphoglucose isomerase. D-Fructose-6-phosphate disodium is a sugar intermediate of the glycolytic pathway .

HY-113381

2-Hydroxybutyric acid 1 Publications Verification α-Hydroxybutyric acid	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . 2-Hydroxybutyric acid is a potential biomarker for type 2 diabetes and preeclampsia . 2-Hydroxybutyric acid prevents the acetaminophen (AP)-induced liver injury .

HY-N9923

2-C-Methyl-D-erythritol 4-phosphate	Bacterial
2-C-Methyl-D-erythritol 4-phosphate is a metabolite intermediate exclusive to the non-mevalonate MEP pathway, predominantly found in prokaryotes, serving as a precursor for the synthesis of isoprenoids and non-isoprenoids, including vitamins; its absence in humans makes it a promising target for the development of bacterium-specific drugs aimed at treating infectious diseases.

HY-113913

12(S)-HPEPE	Prostaglandin Receptor	Inflammation/Immunology
12(S)-HPEPE is a lipoxygenase product and an intermediate metabolite that leads to downregulation of PGHS-2 and has potential anti-inflammatory activity. 12(S)-HPEPE reduces interleukin 1h (IL-1h)-induced PGHS-2 expression in human lung microvascular endothelial cells .

HY-B2124R

10,11-Dihydrocarbamazepine (Standard)	Drug Metabolite	Neurological Disease
10,11-Dihydrocarbamazepine (Standard) is the analytical standard of 10,11-Dihydrocarbamazepine. This product is intended for research and analytical applications. 10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy .

HY-113586

Besifovir Dipivoxil LB-80380	Others	Infection
Besifovir Dipivoxil (LB-80380), an analog of guanosine monophosphate, is an acyclic nucleotide phosphonate with antiviral effect. Besifovir Dipivoxil is rapidly converted by the liver and intestine to the intermediate metabolite LB80331 via the esterification process, subsequently phosphorylated into the di- and triphosphate forms, which act as antiviral DNA synthesis inhibitors. Besifovir Dipivoxil is promising for research of chronic hepatitis B .

HY-121029

Bisegliptin KRP-104	Histone Methyltransferase	Metabolic Disease
Bisegliptin (KRP-104) is a small molecule compound with antidiabetic activity. Bisegliptin is metabolized mainly by converting the cyano group to the carboxylic acid form, and DPP-4 plays a partial role in its metabolism. The carboxylic acid metabolite of bisegliptin can be detected both in vivo and in vitro. In rat experiments, the plasma concentration of the carboxylic acid metabolite of bisegliptin was affected by other DPP inhibitors, showing the complexity of its metabolic process. The amide intermediate of bisegliptin was detected both in vivo and in vitro, and its conversion rate was significantly faster than that of the parent compound when incubated with DPP-4 .

HY-113381R

2-Hydroxybutyric acid (Standard)	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
2-Hydroxybutyric acid (Standard) is the analytical standard of 2-Hydroxybutyric acid. This product is intended for research and analytical applications. 2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . 2-Hydroxybutyric acid is a potential biomarker for type 2 diabetes and preeclampsia . 2-Hydroxybutyric acid prevents the acetaminophen (AP)-induced liver injury .

HY-W015229R

3-Indolepropionic acid (Standard)	Endogenous Metabolite Reactive Oxygen Species	Neurological Disease Metabolic Disease
3-Indolepropionic acid (Standard) is the analytical standard of 3-Indolepropionic acid. This product is intended for research and analytical applications. 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease. In Vitro: 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease . 3-Indolepropionic acid is a more potent scavenger of hydroxyl radicals than melatonin. Similar to melatonin but unlike other antioxidants, 3-Indolepropionic acid scavenges radicals without subsequently generating reactive and pro-oxidant intermediate compounds . It is also suggested that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of type 2 diabetes (T2D) that may mediate its protective effect by preservation of β-cell function .

Cat. No.	Product Name

HY-L123

Human Metabolite Library

6,272 compounds

Human metabolism is an integral part of cellular function that reflects individual differences in health, disease, diet, and lifestyle. Many health conditions such as obesity, diabetes, hypertension, heart disease, and cancer are associated with abnormal metabolic states. In the pathological state of the human body, metabolic pathways are significantly altered, resulting in aberrant levels of intermediates or end-products that can be viewed as potential diagnostic biomarkers or even therapeutic targets. Therefore, detection, identification and quantification of human metabolites are very important for drug metabolism research in drug development.

MCE offers a unique collection of 6,272 human metabolites, including endogenous metabolites and exogenous metabolites, covering multiple structure types, such as lipids, amino acids, nucleic acids, carbohydrates, organic acids, biogenic amines, vitamins,. MCE Human Metabolites Library is a helpful tool for studying the relationship between diseases and metabolism.

Cat. No.	Product Name	Category	Target	Chemical Structure